Volume 16, Number 3—March 2010
Dispatch
Experimental Infection of Squirrel Monkeys with Nipah Virus
Table 1
Clinical course of Nipah virus infection in 12 squirrel monkeys*
Monkey | Mode of infection | Dose, PFU/mL | Day of 1st symptoms | Duration of clinical state | Day of euthanasia | Clinical state at euthanasia | Clinical signs |
---|---|---|---|---|---|---|---|
A† | IV | 103 | – | – | 3 | Well | None |
B | IV | 103 | 10 | 3 | 12† | Moribund | Uncoordinated motor movements, prostration and coma |
C | IV | 103 | 19 | 3 | 21‡ | Moribund | Uncoordinated motor movements, prostration, and coma |
D† | IV | 107 | – | – | 3 | Well | None |
E | IV | 107 | 7 | 2 | 8† | Moribund | Uncoordinated motor movements, prostration, and coma |
F | IV | 107 | 14 | 3 | 52 | Recovered/well | Anorexia, depression |
G† | IN | 103 | – | – | 4 | Well | None |
H | IN | 103 | – | – | 52 | Well | None |
I | IN | 103 | 8 | 3 | 56 | Recovered/well | Anorexia, seizure |
J† | IN | 107 | – | – | 4 | Well | None |
K | IN | 107 | 17 | Septic shock not correlated with NiV infection | |||
L | IN | 107 | 10 | 7 | 56 | Recovered/well | Anorexia, seizure, edema of eyes |
*IV, intravenous; IN, intranasal; NiV, Nipah virus.
†Early systematic euthanasia.
‡Death caused by NiV infection.