Volume 16, Number 3—March 2010
Research
Chikungunya Virus Infection during Pregnancy, Réunion, France, 2006
Xavier Fritel
, Olivier Rollot, Patrick Gérardin, Bernard-Alex Gaüzère, Jacques Bideault, Louis Lagarde, Barbara Dhuime, Eric Orvain, Fabrice Cuillier, Duksha Ramful, Sylvain Sampériz, Marie-Christine Jaffar-Bandjee, Alain Michault, Liliane Cotte, Monique Kaminski, Alain Fourmaintraux, and the Chikungunya-Mère-Enfant Team
, Olivier Rollot, Patrick Gérardin, Bernard-Alex Gaüzère, Jacques Bideault, Louis Lagarde, Barbara Dhuime, Eric Orvain, Fabrice Cuillier, Duksha Ramful, Sylvain Sampériz, Marie-Christine Jaffar-Bandjee, Alain Michault, Liliane Cotte, Monique Kaminski, Alain Fourmaintraux, and the Chikungunya-Mère-Enfant Team
Table 3
Pregnancy outcome according to chikungunya virus infection during pregnancy, Réunion, France, 2006*
| Characteristic | Infected,† no. (%), n = 658 | Not infected,‡ no. (%), n = 655 | p value | Unadjusted OR (95% CI) | Adjusted OR (95% CI) |
|---|---|---|---|---|---|
| Hospital admission during pregnancy | |||||
| Yes | 266 (40.4) | 191 (29.2) | 1.65 (1.31–2.07) | 1.52 (1.18–1.95) | |
| No |
392 (59.6) |
464 (70.8) |
<0.0001 |
1 |
1 |
| Hospital admission during pregnancy, suspected infection with chikungunya virus excluded | |||||
| Yes | 180 (28.0) | 136 (26.1) | 0.91 (0.70–1.18) | 0.83 (0.62–1.10) | |
| No |
464 (72.0) |
385 (73.9) |
0.48 |
1 |
1 |
| Vaginal bleeding during pregnancy | |||||
| Yes | 55 (8.4) | 68 (10.4) | 0.79 (0.55–1.15) | 0.94 (0.63–1.42) | |
| No |
596 (91.6) |
584 (89.6) |
0.22 |
1 |
1 |
| Obstetric hemorrhaging | |||||
| Yes | 36 (5.6) | 42 (6.5) | 0.85 (0.54–1.35) | 0.87 (0.53–1.42) | |
| No |
609 (94.4) |
605 (93.5) |
0.49 |
1 |
1 |
| Mode of delivery§ | |||||
| Vaginal | 545 (83.8) | 530 (81.5) | 0.27 | 1 | 1 |
| Cesarean |
105 (16.2) |
120 (18.5) |
0.85 (0.64–1.14) |
0.77 (0.56–1.06) |
|
| Mean gestational age, wk§ | 39.0 (2.1) | 38.9 (2.5) | 0.55 | ||
| <32 | 8 (1.2) | 15 (2.3) | 0.26 | 0.52 (0.22-1.24) | 0.48 (0.19–1.23) |
| 32–36 | 53 (8.2) | 60 (9.2) | 0.86 (0.59–1.27) | 0.78 (0.51–1.20) | |
| >37 |
589 (90.6) |
575 (88.5) |
1 |
1 |
|
| Mean birthweight, g§ | 3,116 (549) | 3.056 (620) | 0.27 | ||
| <2,000 | 20 (3.1) | 32 (4.9) | 0.36 | 0.62 (0.35–1.11) | 0.66 (0.36–1.22) |
| 2,000–2,999 | 235 (35.9) | 236 (35.7) | 0.99 (0.79–1.25) | 1.01 (0.79–1.30) | |
| 3,000–3,999 | 372 (56.9) | 371 (56.1) | 1 | 1 | |
| >4,000 |
27 (4.1) |
22 (3.3) |
1.22 (0.69–2.19) |
1.25 (0.65–2.39) |
|
| Stillbirth after 22 wk§ | |||||
| Yes | 5 (0.8) | 8 (1.2) | 0.63 (0.20–1.93) | 0.61 (0.18–2.07) | |
| No |
653 (99.2) |
656 (98.8) |
0.41 |
1 |
1 |
| Congenital malformation | |||||
| Yes | 19 (2.9) | 15 (2.2) | 1.36 (0.68–2.74) | 1.54 (0.68–3.49) | |
| No |
647 (97.1) |
654 (97.8) |
0.48 |
1 |
1 |
| Admission to neonatal care§ | |||||
| Yes | 53 (8.1) | 55 (8.3) | 0.97 (0.65–1.44) | 1.03 (0.67–1.58) | |
| No | 605 (91.9) | 609 (91.7) | 0.88 | 1 | 1 |
*OR, odds ratio; CI, confidence interval. OR was adjusted for center, educational level, body mass index, and maternal age. Women infected before pregnancy were considered not infected during pregnancy.
†Of the 658 women who were infected, 650 had delivered a child after 22 weeks; 658 children were delivered by these women.
‡Of the 655 women who were not infected, 650 had delivered a child after 22 weeks; 664 children were delivered by these women.
§Miscarriage before 22 weeks was excluded.
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