Skip directly to site content Skip directly to page options Skip directly to A-Z link Skip directly to A-Z link Skip directly to A-Z link
Volume 16, Number 4—April 2010
Dispatch

Porcine-Origin Gentamicin-Resistant Enterococcus faecalis in Humans, Denmark

Jesper LarsenComments to Author , Henrik C. Schønheyder, Camilla H. Lester, Stefan S. Olsen, Lone J. Porsbo, Lourdes Garcia-Migura, Lars B. Jensen, Magne Bisgaard, and Anette M. Hammerum
Author affiliations: University of Copenhagen, Frederiksberg, Denmark (J. Larsen, M. Bisgaard); Aarhus University Hospital, Aalborg, Denmark (H.C. Schønheyder); Statens Serum Institut, Copenhagen, Denmark (C.H. Lester, S.S. Olsen, A.M. Hammerum); Technical University of Denmark, Søborg, Denmark (L.J. Porsbo); Technical University of Denmark, Copenhagen (L. Garcia-Migura, L.B. Jensen).

Main Article

Table

Origins of gentamicin-resistant Enterococcus faecalis isolates and MICs for gentamicin, Denmark, 2001–2002*

Identification no. Other name Origin Sampling date MIC for gentamicin, μg/mL MLST type
124832 IE patient A 2001 Nov 18 >2,048 16
48250 IE patient B 2002 May 2 >2,048 16
7330318-4 D6 Pig 2001 Mar 29 >2,048 16
7330612-2 D29 Pig 2001 Jul 25 2,048 16
7330948-5 D34 Pig 2001 Nov 23 2,048 16
7330115-2 Pig 2001 Jan 29 >2,048 16
7330445-1 Pig 2001 May 21 2,048 16
7430040-2 Pig 2002 Feb 18 1,024 16
7430049-2 Pig 2002 Feb 22 1,024 16
7430275-3 Pig 2002 May 16 >2,048 16
7430291-2 Pig 2002 May 21 2,048 16
7430297-2 Pig 2002 May 22 >2,048 16
7430315-3 Pig 2002 May 23 2,048 35
7430317-5 Pig 2002 May 23 2,048 16
7430328-3 Pig 2002 May 27 >2,048 16
7430405-1 Pig 2002 Jun 24 >2,048 16
7430411-3 Pig 2002 Jun 25 1,024 16
7430416-2 Pig 2002 Jun 24 1,024 16
7430416-3 Pig 2002 Jun 24 >2,048 16
7430803-2 Pig 2002 Nov 18 >2,048 16
7430821-4 Pig 2002 Nov 21 >2,048 16
19116 Pork 2002 Oct 6 >2,048 16
1448 CD human 2003 Oct 1 >2,048 16
3382 CD human 2005 Dec 9 >2,048 16

*MLST, multilocus sequence typing; IE, infective endocarditis; CD, community dwelling. MLST types in boldface have been published (7).

Main Article

References
  1. Baddour  LM, Wilson  WR, Bayer  AS, Fowler  VG Jr, Bolger  AF, Levison  ME, Infective endocarditis: diagnosis, antimicrobial therapy, and management of complications: a statement for healthcare professionals from the Committee on Rheumatic Fever, Endocarditis, and Kawasaki Disease, Council on Cardiovascular Disease in the Young, and the Councils on Clinical Cardiology, Stroke, and Cardiovascular Surgery and Anesthesia, American Heart Association: endorsed by the Infectious Diseases Society of America. Circulation. 2005;111:e394–434. DOIPubMedGoogle Scholar
  2. Aslangul  E, Ruimy  R, Chau  F, Garry  L, Andremont  A, Fantin  B. Relationship between the level of acquired resistance to gentamicin and synergism with amoxicillin in Enterococcus faecalis. Antimicrob Agents Chemother. 2005;49:4144–8. DOIPubMedGoogle Scholar
  3. Claesson  C, Hallgren  A, Nilsson  M, Svensson  E, Hanberger  H, Nilsson  LE. Susceptibility of staphylococci and enterococci to antimicrobial agents at different ward levels in four north European countries. Scand J Infect Dis. 2007;39:1002–12. DOIPubMedGoogle Scholar
  4. Danish Integrated Antimicrobial Resistance Monitoring and Research Program. DANMAP 2000—consumption of antimicrobial agents and occurrence of antimicrobial resistance in bacteria from food animals, foods and humans in Denmark [cited 2009 Sep 1]. http://www.danmap.org/pdfFiles/Danmap_2000.pdf
  5. Danish Integrated Antimicrobial Resistance Monitoring and Research Program. DANMAP 2001—use of antimicrobial agents and occurrence of antimicrobial resistance in bacteria from food animals, foods and humans in Denmark [cited 2009 Sep 1]. http://www.danmap.org/pdfFiles/Danmap_2001.pdf
  6. Danish Integrated Antimicrobial Resistance Monitoring and Research Program. DANMAP 2002—use of antimicrobial agents and occurrence of antimicrobial resistance in bacteria from food animals, foods and humans in Denmark [cited 2009 Sep 1]. http://www.danmap.org/pdfFiles/Danmap_2002.pdf
  7. Shankar  N, Baghdayan  AS, Willems  R, Hammerum  AM, Jensen  LB. Presence of pathogenicity island genes in Enterococcus faecalis isolates from pigs in Denmark. J Clin Microbiol. 2006;44:4200–3. DOIPubMedGoogle Scholar
  8. Li  JS, Sexton  DJ, Mick  N, Nettles  R, Fowler  VG Jr, Ryan  T, Proposed modifications to the Duke criteria for the diagnosis of infective endocarditis. Clin Infect Dis. 2000;30:633–8. DOIPubMedGoogle Scholar
  9. Garner  JS, Jarvis  WR, Emori  TG, Horan  TC, Hughes  JM. CDC definitions for nosocomial infections, 1988. Am J Infect Control. 1988;16:128–40. DOIPubMedGoogle Scholar
  10. Clinical and Laboratory Standards Institute. Performance standards for antimicrobial susceptibility testing: Fifteenth Informational Supplement M100-S15. Wayne (PA): The Institute; 2005.
  11. Ruiz-Garbajosa  P, Bonten  MJ, Robinson  DA, Top  J, Nallapareddy  SR, Torres  C, Multilocus sequence typing scheme for Enterococcus faecalis reveals hospital-adapted genetic complexes in a background of high rates of recombination. J Clin Microbiol. 2006;44:2220–8. DOIPubMedGoogle Scholar
  12. Turabelidze  D, Kotetishvili  M, Kreger  A, Morris  JG Jr, Sulakvelidze  A. Improved pulsed-field gel electrophoresis for typing vancomycin-resistant enterococci. J Clin Microbiol. 2000;38:4242–5.PubMedGoogle Scholar
  13. Morrison  D, Woodford  N, Barrett  SP, Sisson  P, Cookson  BD. DNA banding pattern polymorphism in vancomycin-resistant Enterococcus faecium and criteria for defining strains. J Clin Microbiol. 1999;37:1084–91.PubMedGoogle Scholar
  14. Donabedian  SM, Thal  LA, Hershberger  E, Perri  MB, Chow  JW, Bartlett  P, Molecular characterization of gentamicin-resistant enterococci in the United States: evidence of spread from animals to humans through food. J Clin Microbiol. 2003;41:1109–13. DOIPubMedGoogle Scholar
  15. Ruiz-Garbajosa  P, Canton  R, Pintado  V, Coque  TM, Willems  R, Baquero  F, Genetic and phenotypic differences among Enterococcus faecalis clones from intestinal colonisation and invasive disease. Clin Microbiol Infect. 2006;12:1193–8. DOIPubMedGoogle Scholar

Main Article

Page created: December 23, 2010
Page updated: December 23, 2010
Page reviewed: December 23, 2010
The conclusions, findings, and opinions expressed by authors contributing to this journal do not necessarily reflect the official position of the U.S. Department of Health and Human Services, the Public Health Service, the Centers for Disease Control and Prevention, or the authors' affiliated institutions. Use of trade names is for identification only and does not imply endorsement by any of the groups named above.
file_external