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Volume 16, Number 5—May 2010
Dispatch

Nosocomial Outbreak of Crimean-Congo Hemorrhagic Fever, Sudan

Imadeldin E. Aradaib, Bobbie R. Erickson, Mubarak E. Mustafa, Marina L. Khristova, Nageeb S. Saeed, Rehab M. Elageb, and Stuart T. NicholComments to Author 
Author affiliations: The National Ribat University, Khartoum, Sudan (I.E. Aradaib); University of Khartoum, Khartoum (I.E. Aradaib); Centers for Disease Control and Prevention, Atlanta, Georgia, USA (B.R. Erickson, M.L. Khristova, S.T. Nichol); Central Public Health Laboratory, Khartoum (M.E. Mustafa); Juba University, Khartoum (M.E. Mustafa); Federal Ministry of Health, Khartoum (N.S. Saeed); National Medical Laboratory, Khartoum (N.S. Saeed, R.M. Elageb)

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Figure

Phylogenetic relationship of Crimean-Congo hemorrhagic fever virus (CCHFV) full-length small (S) segments. Phylogenetic analysis used 47 full-length CCHFV S segments available in GenBank. GARLI (v0.96b8) (9) with default settings was used to generate a maximum-likelihood tree with bootstrap support values from 1,000 replicates. From the analysis, a 50% majority-rule tree was constructed. Virus strains from Sudan patients 1, 2, 3, 6, 7, 8, and 9 (GenBank accession no. GQ862371) were identical, an

Figure. Phylogenetic relationship of Crimean-Congo hemorrhagic fever virus (CCHFV) full-length small (S) segments. Phylogenetic analysis used 47 full-length CCHFV S segments available in GenBank. GARLI (v0.96b8) (9) with default settings was used to generate a maximum-likelihood tree with bootstrap support values from 1,000 replicates. From the analysis, a 50% majority-rule tree was constructed. Virus strains from Sudan patients 1, 2, 3, 6, 7, 8, and 9 (GenBank accession no. GQ862371) were identical, and the virus sequence from patient 4 (GenBank accession no. GQ862372) differed by 1 nt. Each strain is listed by its location, strain name, and year of isolation, when available. Boldface indicates strains from Sudan; braces indicate previously described genetic lineages (8).

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References
  1. Hoogstraal  H. The epidemiology of tick-borne Crimean-Congo haemorrhagic fever in Asia, Europe and Africa. J Med Entomol. 1979;15:307–417.PubMedGoogle Scholar
  2. Swanepoel  R. Crimean-Congo haemorrhagic fever. In: Coetzer JA, Thomson GR, Tustin RC, editors. Infectious diseases of livestock with special reference to southern Africa. Cape Town (South Africa): Oxford University Press; 1994. p. 723–9.
  3. Whitehouse  CA. Crimean-Congo hemorrhagic fever. Antiviral Res. 2004;64:145–60. DOIPubMedGoogle Scholar
  4. Ergonul  O. Crimean-Congo haemorrhagic fever. Lancet Infect Dis. 2006;6:203–14. DOIPubMedGoogle Scholar
  5. Schmaljohn  CS, Nichol  ST. Bunyaviridae. In: Knipe DM, Howley PM, Griffin DE, Lamb RA, Martin MA, Roizman B, et al., editors. Fields virology, 5th ed. Philadelphia: Lippincott, Williams, and Wilkins; 2007. p. 1741–89.
  6. Burney  MI, Ghafoor  A, Saleen  M, Webb  PA, Casals  J. Nosocomial outbreak of viral hemorrhagic fever caused by Crimean hemorrhagic fever–Congo virus in Pakistan, January 1976. Am J Trop Med Hyg. 1980;29:941–7.PubMedGoogle Scholar
  7. Schwarz  TF, Nsanze  H, Longson  M, Nitschko  H, Gilch  S, Shurie  H, Polymerase chain reaction for diagnosis and identification of distinct variants of Crimean-Congo hemorrhagic fever virus in the United Arab Emirates.Am J Trop Med Hyg. 1996;55:190–6.
  8. Deyde  VM, Khristova  ML, Rollin  PE, Ksiazek  TG, Nichol  ST. Crimean-Congo hemorrhagic fever virus genomics and global diversity. J Virol. 2006;80:8834–42. DOIPubMedGoogle Scholar
  9. Zwickl  DJ. Genetic algorithm approaches for the phylogenetic analysis of large biological sequence datasets under the maximum-likelihood criterion [dissertation]. Austin (TX): The University of Texas; 2006.
  10. Watts  DM, Tigani  AE, Botros  BA, Salib  AW, Olson  JG, McCarthy  M, Arthropod-borne viral infections associated with a fever outbreak in the northern province of Sudan.J Trop Med Hyg. 1994;97:228–30.
  11. McCarthy  MC, Haberberger  RL, Salib  AW, Soliman  BA, Tigani  AE, Khalid  OI, Evaluation of arthropod-borne viruses and other infectious disease pathogens as the causes of febrile illnesses in the Khartoum Province of Sudan.J Med Virol. 1996;48:141–6.
  12. Morrill  JC, Soliman  AK, Imam  IZ, Botros  BA, Moussa  MI, Watts  DM. Serological evidence of Crimean-Congo haemorrhagic fever viral infection among camels imported into Egypt. J Trop Med Hyg. 1990;93:201–4.PubMedGoogle Scholar
  13. Hassanein  KM, el-Azazy  A, Yousef  HM. Trans R Soc Trop Med Hyg. 1997;91:536–7.Detection of Crimean-Congo haemorrhagic fever virus antibodies in humans and imported livestock in Saudi Arabia. DOIPubMedGoogle Scholar
  14. Chamberlain  J, Cook  N, Lloyd  G, Mioulet  V, Tolley  H, Hewson  R. Co-evolutionary patterns of variation in small and large RNA segments of Crimean-Congo hemorrhagic fever virus. J Gen Virol. 2005;86:3337–41. DOIPubMedGoogle Scholar
  15. Burt  FJ, Paweska  JT, Ashkettle  B, Swanepoel  R. Genetic relationship in southern African Crimean-Congo haemorrhagic fever virus isolates: evidence for occurrence of reassortment. Epidemiol Infect. 2009;137:1302–8. DOIPubMedGoogle Scholar

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