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Volume 16, Number 8—August 2010
Perspective

Hantavirus Infections in Humans and Animals, China

Yong-Zhen ZhangComments to Author , Yang Zou, Zhen F. Fu, and Alexander Plyusnin
Author affiliations: State Key Laboratory for Infectious Disease Control and Prevention, Beijing, People’s Republic of China (Y.-Z. Zhang, Y. Zou); University of Georgia, Athens, Georgia, USA (Z.F. Fu); University of Helsinki, Helsinki, Finland (A. Plyusnin)

Main Article

Table 1

Major rodent species captured in China, by location and years*

Species Fields, %
Residential areas, %
1984–1990 1991–1995 1996–2000 1984–1990 1991–1995 1996–2000
Apodemus agrarius 57.362 44.508 37.012 3.425 4.411 3.944
Apodemus peninsulae 3.761 8.870 1.516 0.011 0.137 0.125
Apodemus chevrieri 0.318 2.475 4.053 NC 1.820 2.282
Rattus norvegicus 5.081 8.358 10.112 49.106 53.025 54.266
Rattus losea 7.302 6.401 22.457 0.141 0.289 0.087
Rattus flavipectus 1.089 2.674 2.284 13.527 10.969 9.395
Rattus nitidus 0.225 0.158 0.042 0.006 0.007 0.067
Niviventer confucianus 0.775 0.339 0.987 0.138 0.078 0.062
Niviventer fulvescens 1.062 0.164 0.184 0.001 NC NC
Mus musculus 4.635 5.889 4.472 28.625 21.045 20.984
Cricetulus barabensis 3.883 3.946 1.781 0.427 0.171 0.067
Cricetulus longicaudatus 1.124 0.769 NC 0.033 NC NC
Cricetulus migratorius 0.784 1.097 1.120 0.342 0.022 0.766
Cricetulus triton 7.532 8.065 6.282 1.458 3.911 2.657
Meriones meridianus 0.513 NC NC NC NC NC
Meriones erythrourus 0.445 0.070 0.884 0.053 NC 0.004
Myodes rutilus 0.230 0.091 0.558 0.030 0.022 0.017
Myodes rufocanus 0.185 0.319 0.194 0.035 0.037 0.092
Microtus fortis 0.469 1.340 1.368 0.005 NC NC
Microtus maximowiczii 0.274 0.219 0.174 0.073 0.056 0.046
Microtus arvalis 0.176 0.155 0.052 NC NC 0.208
Anourosorex squamipes 0.429 0.342 NC 0.005 2.024 3.919
Crocidrua lasiura 0.418 0.202 0.161 0.012 0.041 0.062
Crocidrua horsfieldi 0.006 0.544 0.026 NC 0.204 0.042
Suncus murinus 0.354 0.427 1.520 1.826 0.489 0.183
Sorex araneus 0.219 0.187 0.303 0.044 0.037 0.258

*Data from Chen and Luo (23). Hantavirus antigens had been identified in all species listed except Anourosorex squamipes mole shrews and Microtus arvalis voles. NC, not captured.

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References
  1. Nichol  ST, Arikawa  J, Kawaoka  Y. Proc Natl Acad Sci U S A. 2000;97:124112.Emerging viral diseases. DOIPubMed
  2. Schönrich  G, Rang  A, Lütteke  N, Raftery  MJ, Charbonnel  N, Ulrich  RG. Hantavirus-induced immunity in rodent reservoirs and humans. Immunol Rev. 2008;225:16389. DOIPubMed
  3. Zeier  M, Handermann  M, Bahr  U, Rensch  B, Müller  S, Kehm  R, New ecological aspects of hantavirus infection: a change of a paradigm and a challenge of prevention—a review. Virus Genes. 2005;30:15780. DOIPubMed
  4. Plyusnin  A, Morzunov  SP. Virus evolution and genetic diversity of hantaviruses and their rodent hosts. Curr Top Microbiol Immunol. 2001;256:4775.PubMed
  5. Easterbrook  JD, Klein  SL. Immunological mechanisms mediating hantavirus persistence in rodent reservoirs. PLoS Pathog. 2008;4:e1000172. DOIPubMed
  6. Schmaljohn  C, Hjelle  B. Hantaviruses, a global disease problem. Emerg Infect Dis. 1997;3:95104. DOIPubMed
  7. Johnson  KM. Introduction. In: Lee HW, Calisher C, Schmaljohn, editors. Manual of hemorrhagic fever with renal syndrome and hantavirus pulmonary syndrome. Seoul (South Korea): WHO Collaborating Center for Virus Reference and Research (Hantaviruses), Asian Institute for Life Sciences; 1999. p. 1–6.
  8. Zou  Y, Xiao  QY, Dng  X, Lv  W, Zhang  SP, Li  MH, Genetic analysis of hantaviruses carried by Microtus fortis voles in China. Virus Res. 2008;137:1228. DOIPubMed
  9. Chen  HX, Qiu  FX. Epidemiological surveillance on the hemorrhagic fever with renal syndrome in China. Chin Med J (Engl). 1993;106:85763.PubMed
  10. Zhang  YZ, Xiao  DL, Wang  Y, Wang  HX, Sun  L, Tao  XX, The epidemic characteristics and preventive measures of hemorrhagic fever with renal syndrome in China [in Chinese]. Zhonghua Liu Xing Bing Xue Za Zhi. 2004;25:4669.PubMed
  11. Wang  H, Yoshimatsu  K, Ebihara  H, Ogino  M, Araki  K, Kariwa  H, Genetic diversity of hantaviruses isolated in China and characterization of novel hantaviruses isolated from Niviventer confucianus and Rattus rattus. Virology. 2000;278:33245. DOIPubMed
  12. Chen  HX, Qiu  FX, Dong  BJ, Ji  SZ, Li  YT, Wang  Y, Epidemiological studies on hemorrhagic fever with renal syndrome in China. J Infect Dis. 1986;154:3948. DOIPubMed
  13. Song  G. Epidemiological progresses of hemorrhagic fever with renal syndrome in China. Chin Med J (Engl). 1999;112:4727.PubMed
  14. Zhang  YZ, Zhang  FX, Wang  JB, Zhao  ZW, Li  MH, Chen  HX, Hantaviruses in rodents and humans in the Inner Mongolia Autonomous Region, China. Emerg Infect Dis. 2009;15:88591. DOIPubMed
  15. Hang  CS, Song  G, Qiu  XZ, Du  YL, Zhao  JN, Liao  HX, Investigation of the agent causing mild type of hemorrhagic fever [in Chinese]. Zhonghua Liu Xing Bing Xue Za Zhi. 1982;3:2045.PubMed
  16. Zuo  SQ, Zhang  PH, Jiang  JF, Zhan  L, Wu  XM, Zhao  WJ, Seoul virus in patients and rodents from Beijing, China. Am J Trop Med Hyg. 2008;78:8337.PubMed
  17. Zhang  YZ, Dong  X, Li  X, Ma  C, Xiong  HP, Gao  N, Seoul virus and hantavirus disease, Shenyang, China. Emerg Infect Dis. 2009;15:2006. DOIPubMed
  18. Engelthaler  DM, Mosley  DG, Cheek  JE, Levy  CE, Komatsu  KK, Ettestad  P, Climatic and environmental patterns associated with hantavirus pulmonary syndrome, Four Corners region, United States. Emerg Infect Dis. 1999;5:8794. DOIPubMed
  19. Vapalahti  O, Mustonen  J, Lundkvist  A, Henttonen  H, Plyusnin  A, Vaheri  A. Hantavirus infections in Europe. Lancet Infect Dis. 2003;3:65361. DOIPubMed
  20. Bi  P, Tong  S, Donald  K, Parton  K, Ni  J. Climatic, reservoir and occupational variables and the transmission of haemorrhagic fever with renal syndrome in China. Int J Epidemiol. 2002;31:18993. DOIPubMed
  21. Chen  HX, Qiu  FX. Studies on the environment structure of natural nidi and epidemic areas of hemorrhagic fever with renal syndrome in China. Chin Med J (Engl). 1994;107:10712.PubMed
  22. Yan  L, Fang  LQ, Huang  HG, Zhang  LQ, Feng  D, Zhao  WJ, Landscape elements and Hantaan virus–related hemorrhagic fever with renal syndrome, People's Republic of China. Emerg Infect Dis. 2007;13:13016.PubMed
  23. Chen  HX, Luo  CW. Hemorrhagic fever with renal syndrome: studies and the surveillance and application of vaccine [in Chinese]. Hong Kong: Hong Kong Medical Publisher; 2001. p. 1–163.
  24. Liu  RH, Chen  HX. The risk and prevention of hemorrhagic fever with renal syndrome transmitted by laboratory rats [in Chinese]. Chin J Vector Biol Control 1991;2(S):250–4.
  25. Wang  GD, Li  SG, Hen  SQ, Liu  LJ, Yang  WX, Zhang  WF, Survey of outbreak of hemorrhagic fever with renal syndrome as a result of experimental white rat infection. Zhonghua Liu Xing Bing Xue Za Zhi. 1985;4:2335.
  26. Luo  L, Dong  ZQ, Wang  YL. Investigation and analysis of lab infection affair of HFRS in Guangzhou, China [in Chinese]. Med Ani Prev. 2008;24:5860.
  27. Zhang  RZ, Jing  SK, Quan  GQ, Li  SH, Ye  ZY, Wang  FG, , eds. Muridae. In: Distribution of mammalian species in China. Beijing: China Forestry Publishing House; 1997. p. 185–211.
  28. Luo  ZZ. Liu GZ, editors. Geographical epidemiological investigation of epidemiological fever in China [in Chinese]. Hefei (China): Anhui Press Bureau; 1990. p. 52–63.
  29. Zhang  YZ, Zou  Y, Yan  YZ, Hu  GW, Yao  LS, Du  ZS, Detection of phylogenetically distinct Puumala-like viruses from red-grey vole Clethrionomys rufocanus in China. J Med Virol. 2007;79:120818. DOIPubMed
  30. Zou  Y, Wang  JB, Gaowa  HS, Yao  LS, Hu  GW, Li  MH, Isolation and genetic characterization of hantavirus carried by Microtus voles in China. J Med Virol. 2008;80:6808. DOIPubMed
  31. Yan  YC, Liu  XL, Yang  ZB, Li  ZL. Propagation and characterization of the etiologic agent of epidemic hemorrhagic fever in cultured A-549 cells [in Chinese]. Zhongguo Yi Xue Ke Xue Yuan Xue Bao. 1982;4:6772.PubMed
  32. Zou  Y, Hu  J, Wang  ZX, Wand  DM, Li  MH, Ren  GD, Molecular diverstiy of Hantaan virus in Guizhou, China: evidence for origin of Hantaan virus from Guizhou. J Gen Virol. 2008;89:198797. DOIPubMed
  33. Zhang  YZ, Zou  Y, Yao  LS, Hu  GW, Du  ZS, Jin  LZ, Isolation and characterization of hantavirus carried by Apodemus peninsulae in Jilin, China. J Gen Virol. 2007;88:1295301. DOIPubMed
  34. Zou  Y, Hu  J, Wang  ZX, Wang  DM, Yu  C, Zhou  JZ, Genetic characterization of hantaviruses isolated from Guizhou, China: evidence for spillover and reassortment in nature. J Med Virol. 2008;80:103341. DOIPubMed
  35. Song  G, Hang  CS, Liao  HX, Fu  JL, Gao  GZ, Qiu  HL, Antigenic difference between viral strains causing classical and mild types of epidemic hemorrhagic fever with renal syndrome in China. J Infect Dis. 1984;150:88994. DOIPubMed
  36. Kariwa  H, Yoshimatsu  K, Sawabe  J, Yokota  E, Arikawa  J, Takashima  I, Genetic diversities of hantaviruses among rodents in Hokkaido, Japan and Far East Russia. Virus Res. 1999;59:21928. DOIPubMed
  37. Song  G, Hang  CS, Huang  YC, Hou  FY. Preliminary trials of inactivated vaccine against haemorrhagic fever with renal syndrome. Lancet. 1991;337:801. DOIPubMed
  38. Song  G, Huang  YC, Hang  CS, Li  SL, Liu  WM, Fu  ZW, Human trial of a bivalent inactivated golden hamster kidney cell (GHKC) vaccine against epidemic hemorrhagic fever (EHF) [in Chinese]. Bing Du Xue Bao. 1993;9:14451.
  39. Chen  HX, Luo  ZZ, Zhang  JJ; Hantavirus Vaccine Efficacy Evaluation Working Group. Large-scale field evaluation on vaccines of hemorrhagic fever with renal syndrome in China [in Chinese]. Zhonghua Liu Xing Bing Xue Za Zhi. 2002;23:1457.
  40. Dong  GM, Han  L, An  Q, Liu  WX, Kong  Y, Yang  LH. Immunization effect of purified bivalent vaccine to haemorrhagic fever with renal syndrome manufactured from primary cultured hamster kidney cells. Chin Med J (Engl). 2005;118:7668.PubMed

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Page created: March 30, 2011
Page updated: March 30, 2011
Page reviewed: March 30, 2011
The conclusions, findings, and opinions expressed by authors contributing to this journal do not necessarily reflect the official position of the U.S. Department of Health and Human Services, the Public Health Service, the Centers for Disease Control and Prevention, or the authors' affiliated institutions. Use of trade names is for identification only and does not imply endorsement by any of the groups named above.
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