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Volume 16, Number 8—August 2010
Research

Outbreak of Corynebacterium pseudodiphtheriticum Infection in Cystic Fibrosis Patients, France

Fadi Bittar1, Carole Cassagne1, Emmanuelle Bosdure, Nathalie Stremler, Jean-Christophe Dubus, Jacques Sarles, Martine Reynaud-Gaubert, Didier Raoult, and Jean-Marc RolainComments to Author 

Author affiliations: Université de la Méditerranée, Marseille, France (F. Bittar, C. Cassagne, D. Raoult, J.-M. Rolain); Hôpital Timone, Marseille (E. Bosdure, N. Stremler, J.-C. Dubus, J. Sarles); Hôpital Sainte-Marguerite, Marseille (M. Reynaud-Gaubert)

Main Article

Patient Age/sex Isolate Symptoms Treatment Sample Other isolated pathogens Identification
 Ery SXT
ApiCoryne
 rpoB PCR
 MALDI-TOF MS
Result % Code Result % Accession no. Result Score value†
A 4 mo/F A1 Cough Unknown BAL SA, fungi CP 96.8 3001004 CP 99 AY492232 CP 1,815 R S
A2 None Unknown BAL None CP 96.8 3001004 CP 99 AY492232 CP 2,492 R S
A3 Unknown Unknown BAL None CP 99 7001004 CP 99 AY492232 CP 1,950 R I
B 35 mo/F B Rhinitis None NPA HI CP 96.8 3001004 CP 97 AY492232 CP 2,051 R S
C 5 y/M C None None SP SA CP 84.6 3003004 CP 100 AY492232 CP 2,477 S S
D 10 y/F D None None SP CAL CP 94.9 3101004 CP 100 AY492232 CP 2,272 I S
E 13 mo E Unknown Unknown BAL None Br UIP 5101764 CP 100 AY492232 CP 2,353 S S
F 2 y/M F Cough AMX and SXT BAL SA, fungi CP 94.9 3101004 CP 99 AY492232 CP 2,416 S I
G 15 mo/F G1 Cough AUG NPA SA CP 97.9 5101007 CP 97 AY492232 CP 2,246 R S
G2 None None NPA None CPQ 88 3000004 CP 100 AY492232 CP 2,069 R S
H 35 mo/F H Rhinitis, cough AMX NPA SA CP 92.3 1021004 CP 99 AY492232 CP 1,914 R S
I 2 mo/F I1 Cough None NPA EC CP 1.1 2001004 CP 98 AY492232 CP 2,444 R S
I2 Cough None NPA EC CP 95 3101004 CP 98 AY492232 CP 2,406 S S
J 9 y/F J Cough SXT then AMX SP None CP 94.9 3101004 CP 98 AY492232 CP 2,461 S S
K 21 mo/M K1 Rhinitis, cough AUG NPA BC CP 97.9 5101004 CP 98 AY492232 CP 2,386 R S
K2 Rhinitis AUG NPA HI CP 94.9 3101004 CP 98 AY492232 CP 2,044 R S
L 3 y/M L Cough SXT NPA BC CP 94.9 3101004 CP 98 AY492232 CP 2,098 R S
M 16 y/F M Rhinitis None SP None CP 96.8 3001004 CP 98 AY492232 CP 1,787 S R

*MALDI-TOF MS, matrix-assisted laser desorption/ionization time-of-flight mass spectrometry; Ery, erythromycin; SXT, cotrimoxazole; BAL, bronchoalveolar fluid; SA, Staphylococcus aureus; CP, Corynebacterium pseudodiphtheriticum; R, resistant; S, sensitive; I, intermediary; NPA, nasopharyngeal aspirate; SP, sputum sample; HI, Haemophilus influenzae; CAL, Candida albicans; Br, Brevibacterium sp; UIP, uninterpretable pattern; AMX, amoxicillin; AUG, amoxicillin and clavulanic acid; CPQ, Corynebacterium propinquum; EC, Escherichia coli; BC, Branhamella catarrhalis.
†Score value represents the mean of 3 different analyses.

Main Article

1These authors contributed equally to this article.

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Page updated: March 30, 2011
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