Influenza B Viruses with Mutation in the Neuraminidase Active Site, North Carolina, USA, 2010–11
Katrina Sleeman, Tiffany G. Sheu, Zack Moore, Susan Kilpatrick, Shikha Garg, Alicia M. Fry, and Larisa V. Gubareva
Author affiliations: Centers for Disease Control and Prevention, Atlanta, Georgia, USA (K. Sleeman, T.G. Sheu, S. Garg, A.M. Fry, L.V. Gubareva); Battelle, Atlanta (T.G. Sheu); North Carolina Department of Health and Human Services, Raleigh, North Carolina, USA (Z. Moore, S. Kilpatrick)
Figure. Phylogenetic analysis of A) hemagglutinin and B) neuraminidase genes of Victoria lineage type B influenza viruses (n = 89). Red indicates the 2010−2011 Northern Hemisphere vaccine strain; blue indicates the cluster of influenza B viruses identified in North Carolina carrying the I221V substitution in the neuraminidase; green indicates viruses collected from North Carolina with wild-type sequence at position 221 in the neuraminidase; black indicates representatives of globally circulating influenza B viruses. Month of collection is shown after virus strain designation. Evolutionary distances were computed by using the Tamura-Nei method (www.megasoftware.net/WebHelp/part_iv___evolutionary_analysis/computing_evolutionary_distances/distance_models/nucleotide_substitution_models/hc_tamura_nei_distance.htm). Scale bars indicate number of base substitutions per site.
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