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Volume 17, Number 12—December 2011
Research

Hepatitis E Virus in Rats, Los Angeles, California, USA

Robert H. Purcell, Ronald E. Engle, Michael P. Rood, Yamina Kabrane-Lazizi1, Hanh T. Nguyen, Sugantha Govindarajan, Marisa St. Claire2, and Suzanne U. EmersonComments to Author 
Author affiliations: National Institutes of Health, Bethesda Maryland, USA (R.H. Purcell, R.E. Engle, Y. Kabrane-Lazizi, H.T. Nguyen, S.U. Emerson); Department of Public Health Services, Los Angeles, California, USA (M.P. Rood); Rancho Los Amigos Hospital, Downey, California, USA (S. Govindarajan); Bioqual, Inc., Rockville, Maryland, USA (M. St. Claire)

Main Article

Table 1

Results of testing for transmission of human and swine HEV to laboratory rats, Los Angeles, California, USA*

Inoculum
 Genotype
 ID50
 No. injected
 No. with HEV RNA or antibodies against HEV
Sar 55 1 103.8† 2 0
Akluj-90 1 104.8† 2 0
Kashi-87 1 108.1‡ 2 0
Mex14 2 104.3† 4 0
Meng 3 104.3§ 4 0
Meng 3 102.3 4 0

*HEV, hepatitis E virus. The 50% infectious dose (ID50) was administered intravenously.
†In human feces and titered in macaques.
‡Quantitative reverse transcription PCR titer.
§In pig feces and titered in pigs.
¶In macaque feces and titered in macaques.

Main Article

1Current affiliation: Embassy of France, Beijing, People’s Republic of China.

2Current affiliation: National Institutes of Health, Frederick, Maryland, USA.

Page created: November 30, 2011
Page updated: November 30, 2011
Page reviewed: November 30, 2011
The conclusions, findings, and opinions expressed by authors contributing to this journal do not necessarily reflect the official position of the U.S. Department of Health and Human Services, the Public Health Service, the Centers for Disease Control and Prevention, or the authors' affiliated institutions. Use of trade names is for identification only and does not imply endorsement by any of the groups named above.
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