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Volume 17, Number 2—February 2011

Letter

New Delhi Metallo-β-Lactamase, Ontario, Canada

Nathalie Tijet, David C. Alexander, David Richardson, Olga Lastovetska, Donald E. Low, Samir N. Patel, and Roberto G. MelanoComments to Author 
Author affiliations: Author affiliations: Ontario Agency for Health Protection and Promotion, Toronto, Ontario, Canada (N. Tijet, D.C. Alexander, O. Lastovetska, D.E. Low, S.N. Patel, R.G. Melano); University of Toronto, Toronto (D.C. Alexander, O. Lastovetska, D.E. Low, S.N. Patel); William Osler Health Centre, Brampton Civic Hospital, Brampton, Ontario, Canada (D. Richardson); Mount Sinai Hospital, Toronto (D.E. Low, R.G. Melano)

Main Article

Table

Antibacterial drug susceptibility profiles and resistance genes of Klebsiella pneumoniae GN529 clinical isolate and its Escherichia coli transconjugant, Ontario, Canada, 2010*

Antibacterial drug or gene
 MIC, μg/mL
Kpn GN529
 Eco J529
 Eco J53
Ampicillin >256 >256 6
Cefoxitin >256 >256 8
Ceftazidime >256 >256 0.19
Cefotaxime >256 >256 0.094
Cefepime 48 48 0.064
Ertapenem 32 12 0.008
Meropenem >32 4 0.023
Imipenem >32 32 0.38
Amikacin >256 >256 1.5
Gentamicin >256 >256 1.5
Tobramycin >256 >256 1
Ciprofloxacin >32 0.012 0.012
Tetracycline >16 0.78 1
Tigecycline 1 ND ND
Nitrofurantoin >512 ND ND
Colistin 0.5 ND ND
Co-trimoxazole
 4/76
 ND
 ND
PCR† and sequencing
blaNDM-1 + + ND
blaCTX-M-15 + − ND
blaSHV-12 + + ND
blaSHV-11 + – ND
blaOXA-1 + – ND
blaTEM-1 + – ND
armA + + ND

*Kpn, Klebsiella pneumoniae; Eco J529, Escherichia coli transconjugant strain; Eco J53, recipient E. coli J53; ND, not determined.
†PCR screening included blaTEM, blaSHV, blaOXA-1-like, blaCTX-M groups 1, 2, and 9, blaVEB, blaPER, blaGES, blaOXA-48-like, blaIMP, blaVIM, blaKPC, blaNDM-1, and 6 groups of blaAmpC genes.

Main Article

Page created: July 13, 2011
Page updated: July 13, 2011
Page reviewed: July 13, 2011
The conclusions, findings, and opinions expressed by authors contributing to this journal do not necessarily reflect the official position of the U.S. Department of Health and Human Services, the Public Health Service, the Centers for Disease Control and Prevention, or the authors' affiliated institutions. Use of trade names is for identification only and does not imply endorsement by any of the groups named above.
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