Volume 17, Number 2—February 2011
Letter
New Delhi Metallo-β-Lactamase, Ontario, Canada
Table
Antibacterial drug susceptibility profiles and resistance genes of Klebsiella pneumoniae GN529 clinical isolate and its Escherichia coli transconjugant, Ontario, Canada, 2010*
Antibacterial drug or gene |
MIC, μg/mL |
||
Kpn GN529 |
Eco J529 |
Eco J53 |
|
Ampicillin | >256 | >256 | 6 |
Cefoxitin | >256 | >256 | 8 |
Ceftazidime | >256 | >256 | 0.19 |
Cefotaxime | >256 | >256 | 0.094 |
Cefepime | 48 | 48 | 0.064 |
Ertapenem | 32 | 12 | 0.008 |
Meropenem | >32 | 4 | 0.023 |
Imipenem | >32 | 32 | 0.38 |
Amikacin | >256 | >256 | 1.5 |
Gentamicin | >256 | >256 | 1.5 |
Tobramycin | >256 | >256 | 1 |
Ciprofloxacin | >32 | 0.012 | 0.012 |
Tetracycline | >16 | 0.78 | 1 |
Tigecycline | 1 | ND | ND |
Nitrofurantoin | >512 | ND | ND |
Colistin | 0.5 | ND | ND |
Co-trimoxazole |
4/76 |
ND |
ND |
PCR† and sequencing | |||
blaNDM-1 | + | + | ND |
blaCTX-M-15 | + | − | ND |
blaSHV-12 | + | + | ND |
blaSHV-11 | + | – | ND |
blaOXA-1 | + | – | ND |
blaTEM-1 | + | – | ND |
armA | + | + | ND |
*Kpn, Klebsiella pneumoniae; Eco J529, Escherichia coli transconjugant strain; Eco J53, recipient E. coli J53; ND, not determined.
†PCR screening included blaTEM, blaSHV, blaOXA-1-like, blaCTX-M groups 1, 2, and 9, blaVEB, blaPER, blaGES, blaOXA-48-like, blaIMP, blaVIM, blaKPC, blaNDM-1, and 6 groups of blaAmpC genes.