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Volume 17, Number 3—March 2011
Dispatch

Multidrug-Resistant Genotypes of Plasmodium falciparum, Myanmar

Zhaoqing Yang1, Chaoqun Li1, Miao Miao, Zaixing Zhang, Xiaodong Sun, Hao Meng, Jie Li, Qi Fan, and Guiyun YanComments to Author 
Author affiliations: Author affiliations: Kunming Medical University, Yunnan, People’s Republic of China (Z. Yang, C. Li, J. Li); Yunnan Institute of Parasitic Diseases, Pu’er, Yunnan, (Z. Zhang, X. Sun); The Pennsylvania State University, University Park, Pennsylvania, USA (M. Miao, H. Meng, L. Cui); Dalian Institute of Biotechnology, Dalian, Liaoning, People’s Republic of China (Q. Fan)

Main Article

Table 2

Prevalence of the pfnhe1 minisatellite ms4760 haplotypes in the clinical samples from Kachin State, northeast Myanmar, 2007–2009*

Haplotype† No. rep 1 No. rep 2 Haplotype frequency, %
1 2 2 12.7
3 1 2 5.1
5 4 1 3.8
6 2 1 13.9
7 3 1 54.4
9 3 2 3.8
14 3 1 1.3
18 2 2 2.5
34 4 1 1.3
35 1 1 1.3

*Pfnhe1, Plasmodium falciparum Na+/H+ exchanger.
†Numbers refer to the haplotype list of Meng et al. (5).

Main Article

References
  1. Socheat  D, Denis  MB, Fandeur  T, Zhang  Z, Yang  H, Xu  J, Mekong malaria. II. Update of malaria, multi-drug resistance and economic development in the Mekong region of Southeast Asia. Southeast Asian J Trop Med Public Health. 2003;34(Suppl 4):1102.PubMedGoogle Scholar
  2. Wootton  JC, Feng  X, Ferdig  MT, Cooper  RA, Mu  J, Baruch  DI, Genetic diversity and chloroquine selective sweeps in Plasmodium falciparum. Nature. 2002;418:3203. DOIPubMedGoogle Scholar
  3. Roper  C, Pearce  R, Nair  S, Sharp  B, Nosten  F, Anderson  T. Intercontinental spread of pyrimethamine-resistant malaria. Science. 2004;305:1124. DOIPubMedGoogle Scholar
  4. Noedl  H, Se  Y, Schaecher  K, Smith  BL, Socheat  D, Fukuda  MM. Evidence of artemisinin-resistant malaria in western Cambodia. N Engl J Med. 2008;359:261920. DOIPubMedGoogle Scholar
  5. Meng  H, Zhang  R, Yang  H, Fan  Q, Su  X, Miao  J, In vitro sensitivity of Plasmodium falciparum clinical isolates from the China–Myanmar border area to quinine and association with polymorphism in the Na+/H+ exchanger. Antimicrob Agents Chemother. 2010;54:430613. DOIPubMedGoogle Scholar
  6. Yang  Z, Zhang  Z, Sun  X, Wan  W, Cui  L, Zhang  X, Molecular analysis of chloroquine resistance in Plasmodium falciparum in Yunnan Province, China. Trop Med Int Health. 2007;12:105160. DOIPubMedGoogle Scholar
  7. Henry  M, Briolant  S, Zettor  A, Pelleau  S, Baragatti  M, Baret  E, Plasmodium falciparum Na+/H+ exchanger 1 transporter is involved in reduced susceptibility to quinine. Antimicrob Agents Chemother. 2009;53:192630. DOIPubMedGoogle Scholar
  8. Okombo  J, Kiara  SM, Rono  J, Mwai  L, Pole  L, Ohuma  E, In vitro activities of quinine and other antimalarials and pfnhe polymorphisms in Plasmodium isolates from Kenya. Antimicrob Agents Chemother. 2010;54:33027. DOIPubMedGoogle Scholar
  9. Andriantsoanirina  V, Menard  D, Rabearimanana  S, Hubert  V, Bouchier  C, Tichit  M, Association of microsatellite variations of Plasmodium falciparum Na+/H+ exchanger (Pfnhe-1) gene with reduced in vitro susceptibility to quinine: lack of confirmation in clinical isolates from Africa. Am J Trop Med Hyg. 2010;82:7827. DOIPubMedGoogle Scholar
  10. Ferdig  MT, Cooper  RA, Mu  J, Deng  B, Joy  DA, Su  XZ, Dissecting the loci of low-level quinine resistance in malaria parasites. Mol Microbiol. 2004;52:98597. DOIPubMedGoogle Scholar
  11. Smithuis  FM, Monti  F, Grundl  M, Oo  AZ, Kyaw  TT, Phe  O, Plasmodium falciparum: sensitivity in vivo to chloroquine, pyrimethamine/sulfadoxine and mefloquine in western Myanmar. Trans R Soc Trop Med Hyg. 1997;91:46872. DOIPubMedGoogle Scholar
  12. Smithuis  F, Shahmanesh  M, Kyaw  MK, Savran  O, Lwin  S, White  NJ. Comparison of chloroquine, sulfadoxine/pyrimethamine, mefloquine and mefloquine-artesunate for the treatment of falciparum malaria in Kachin State, north Myanmar. Trop Med Int Health. 2004;9:118490. DOIPubMedGoogle Scholar
  13. Wongsrichanalai  C, Lin  K, Pang  LW, Faiz  MA, Noedl  H, Wimonwattrawatee  T, In vitro susceptibility of Plasmodium falciparum isolates from Myanmar to antimalarial drugs. Am J Trop Med Hyg. 2001;65:4505.PubMedGoogle Scholar
  14. Khim  N, Bouchier  C, Ekala  MT, Incardona  S, Lim  P, Legrand  E, Countrywide survey shows very high prevalence of Plasmodium falciparum multilocus resistance genotypes in Cambodia. Antimicrob Agents Chemother. 2005;49:314752. DOIPubMedGoogle Scholar
  15. Anderson  TJ, Nair  S, Sudimack  D, Williams  JT, Mayxay  M, Newton  PN, Geographical distribution of selected and putatively neutral SNPs in Southeast Asian malaria parasites. Mol Biol Evol. 2005;22:236274. DOIPubMedGoogle Scholar

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1These authors contributed equally to this article.

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