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Volume 17, Number 6—June 2011
Research

Invasive Group A Streptococcal Infection and Vaccine Implications, Auckland, New Zealand

Atheer Safar, Diana LennonComments to Author , Joanna Stewart, Adrian Trenholme, Dragana Drinkovic, Briar Peat, Susan Taylor, Kerry Read, Sally Roberts, and Lesley Voss
Author affiliations: Author affiliations: Auckland City Hospital, Auckland, New Zealand (A. Safar, S. Roberts); The University of Auckland, Auckland (D. Lennon, J. Stewart); Kidz First Children’s Hospital/Middlemore Hospital, Auckland (A. Trenholme); North Shore Hospital, Auckland (D. Drinkovic, K. Read); The University of Auckland/Middlemore Hospital, Auckland (B. Peat); Middlemore Hospital, Auckland (S. Taylor); Starship Children’s Hospital, Auckland (L. Voss)

Main Article

Table 3

Clinical syndromes and CFRs for 225 patients with invasive GAS disease, Auckland, New Zealand, 2005–2006*

Diagnosis† Age group, y
 All ages, no. (%),‡ N = 225 p value§
0–14, n = 36
 >15, n = 189
No. CFR No. CFR
Skin and soft tissue infection¶ 11 0 86 8 97 (43) 0.14
Bacteremia only 7 38 31 19 38 (16) 0.63
STSS#** 6 67†† 24 54 30 (13) 0.59
Bone infection 6 0 20 0 26 (12) 0.39
Pneumonia and other respiratory infection 12 13 12 0 24 (11) 0.0001
Necrotizing fasciitis** 1 0 19 15 20 (9) 0.21
Pelvic infection/peripartum‡‡ 0 0 12 0 12 (5)

*CFR, case-fatality rate; GAS, group A streptococcal; STSS, streptococcal toxic shock syndrome.
†Patients may have had >1 diagnosis, with the exception of bacteremia without a source. Other conditions (not shown) included 4 upper airway infections 6 ear/nose/throat infections, 5 central nervous system infections, 4 cases of peritonitis, 3 urinary tract infections, and 2 hemodialysis vascular access infections. No deaths occurred in this group.
‡Overall CFR 10% (22/225).
§p value calculated by using Fisher exact test, a test of difference between age groups.
¶Includes cellulitis (n = 79), cutaneous abscess, boil, lymphadenitis, myositis, bursitis, infected burn, infected scabies, and infected ulcer with evidence of documented bacteremia.
#STSS confirmed and probable (n = 3).
**Five patients had STSS and NF; 1/5 died (20% CFR).
††Three of 6 were community deaths in infants <1 y of age.
‡‡Includes pregnancy-related (n = 6) endometritis and infected products, urinary tract infection/chorioamnionitis, and wound problems.

Main Article

Page created: August 03, 2011
Page updated: August 03, 2011
Page reviewed: August 03, 2011
The conclusions, findings, and opinions expressed by authors contributing to this journal do not necessarily reflect the official position of the U.S. Department of Health and Human Services, the Public Health Service, the Centers for Disease Control and Prevention, or the authors' affiliated institutions. Use of trade names is for identification only and does not imply endorsement by any of the groups named above.
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