Volume 17, Number 6—June 2011
Invasive Group A Streptococcal Infection and Vaccine Implications, Auckland, New Zealand
|Age group, y (no. emm typed)||Assumed vaccine efficacy, %||Assumed vaccine coverage, %||No. (%) persons with GAS disease from emm types in the 26-valent vaccine†||GAS-related deaths from emm type in the 26-valent vaccine†, %||Potential GAS disease prevented %‡||Potential GAS-related deaths prevented, %§|
|<5 (25)||>84||80¶||11 (44)||1#||29.6||0.67|
|>65 (59)||84||60**||18 (30.5)||14 (1/7)||15||7.1|
*GAS, group A streptococcal.
†Among patients with typed isolates.
‡Percentage of assumed vaccine efficacy × percentage of assumed vaccine coverage × persons with GAS disease from 26-valent emm types (based on O’Loughlin et al. ).
§Percentage of assumed vaccine efficacy × percentage of assumed vaccine coverage × persons with GAS disease from 26-valent emm types × percentage of GAS-related deaths associated with a 26-valent emm type.
¶Craig et al. (24).
#Of the 4 children <5 years of age, 2 had an emm typed isolate. Neither of these types is in the proposed vaccine. These are very small numbers.
**New Zealand Ministry of Health Immunisation Handbook (www.moh.govt.nz).
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