Volume 17, Number 6—June 2011
Letter
Macrolide Resistance–associated 23S rRNA Mutation in Mycoplasma genitalium, Japan
Yasushi Shimada, Takashi Deguchi
, Keita Nakane, Mitsuru Yasuda, Shigeaki Yokoi, Shin-ichi Ito, Masahiro Nakano, Shin Ito, and Hiroaki Ishiko
, Keita Nakane, Mitsuru Yasuda, Shigeaki Yokoi, Shin-ichi Ito, Masahiro Nakano, Shin Ito, and Hiroaki Ishiko
Table
Mutations in the 23S rRNA gene and amino acid changes in L4 and L22 ribosomal proteins of 25 Mycoplasma genitalium strains in the pretreatment urine specimens of men with nongonococcal urethritis, Japan
| No. urine specimens |
Mutation in the 23S rRNA gene* |
Amino acid change | |
|---|---|---|---|
| L4 |
L22 |
||
| 1 | A2059G | – | Gly93Glu/Asp109Glu |
| 1 | T2185G | Val84Gly | – |
| 1 | T2185G | GLu128Gly | – |
| 2 | T2185G | – | – |
| 1 | – | Pro81Ser | – |
| 1 | – | Tyr135Pro | – |
| 1 | – | – | Ser81Thr |
| 1 | – | – | Met82Lys |
| 1 | – | – | Asn112Asp |
| 1 | – | – | Arg114Lys |
| 14 | – | – | – |
*Nucleotide position in the 23S rRNA gene is according to Escherichia coli numbering. –, identical to the type strain.
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