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Volume 17, Number 6—June 2011


Macrolide Resistance–associated 23S rRNA Mutation in Mycoplasma genitalium, Japan

Yasushi Shimada, Takashi DeguchiComments to Author , Keita Nakane, Mitsuru Yasuda, Shigeaki Yokoi, Shin-ichi Ito, Masahiro Nakano, Shin Ito, and Hiroaki Ishiko
Author affiliations: Author affiliations: Gifu University, Gifu, Japan (Y. Shimada, T. Deguchi, K. Nakane, M. Yasuda, S. Yokoi, S.-I. Ito, M. Nakano); Mitsubishi Chemical Medience Corporation, Chiba, Japan (Y. Shimada, H. Ishiko); iClinic, Sendai, Japan (S. Ito)

Main Article


Mutations in the 23S rRNA gene and amino acid changes in L4 and L22 ribosomal proteins of 25 Mycoplasma genitalium strains in the pretreatment urine specimens of men with nongonococcal urethritis, Japan

No. urine specimens
Mutation in the 23S rRNA gene*
Amino acid change
1 A2059G Gly93Glu/Asp109Glu
1 T2185G Val84Gly
1 T2185G GLu128Gly
2 T2185G
1 Pro81Ser
1 Tyr135Pro
1 Ser81Thr
1 Met82Lys
1 Asn112Asp
1 Arg114Lys

*Nucleotide position in the 23S rRNA gene is according to Escherichia coli numbering. –, identical to the type strain.

Main Article