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Volume 17, Number 6—June 2011
Research

Use of Antiviral Drugs to Reduce Household Transmission of Pandemic (H1N1) 2009, United Kingdom1

Richard G. PebodyComments to Author , Ross Harris, George Kafatos, Mary Chamberland, Colin Campbell, Jonathan S. Nguyen-Van-Tam, Estelle McLean, Nick Andrews, Peter J. White, Edward Wynne-Evans, Jon Green, Joanna Ellis, Tim Wreghitt, Sam Bracebridge, Chikwe Ihekweazu, Isabel Oliver, Gillian E. Smith, Colin Hawkins, Roland Salmon, Brian Smyth, Jim McMenamin, Maria Zambon, Nick F. Phin, and John M. Watson
Author affiliations: Author affiliations: Health Protection Agency, London, UK (R.G. Pebody, R. Harris, G. Kafatos, M. Chamberland, C. Campbell, J.S. Nguyen-Van-Tam, E. McLean, N. Andrews, P.J. White, E. Wynne-Evans, J. Green, J. Ellis, T. Wreghitt, S. Bracebridge, C. Ihekweazu, I. Oliver, G. Smith, C. Hawkins, M. Zambon, N. Phin, J.M. Watson); Imperial College, London (P.J. White); Public Health Wales, Cardiff, Wales, UK (R. Salmon); Public Health Agency Northern Ireland, Belfast, Northern Ireland (B. Smyth); Health Protection Scotland, Glasgow, Scotland (J. McMenamin)

Main Article

Table 3

Confirmed SAR of pandemic (H1N1) 2009 virus infection, according to time antiviral drug prophylaxis began after onset of illness in primary case-patient, plus timing of secondary cases after onset of primary case, United Kingdom, 2009*

Timing
 No. contacts
 No. secondary case-patients at 14 d
 SAR, % (95% CI)
 No. (%) secondary case-patients
2 d
 3–4 d
 5–7 d
 >7 d
No prophylaxis
 143
 45
 31.5 (24.0–39.8)
 15
 12
 10
 8
Day 0 57 1 1.8 (0.0–9.4) 0 0 1 0
Days 1–2 (<48 h) 81 4 4.9 (1.4–12.2) 0 3 1 0
Day 3–7 (inclusive) 214 3 1.4 (0.3–4.0) NA 0 3 0
>7 d
 92
 0
 0.0 (0.0-3.9)
 NA
 NA
 NA
 0
Total case-patients 587 53 9.0 (6.8–11.7) 15 (2.6) 15 (2.6) 15 (2.6) 8 (1.4)

*SAR, secondary attack rate; CI, confidence interval; NA, not applicable.

Main Article

1Elements of this work were presented at the Health Protection Agency Annual Conference in 2009. An abstract was presented at the International Conference on Emerging Infectious Diseases, Atlanta, Georgia, USA, 2010.

Page created: August 03, 2011
Page updated: August 03, 2011
Page reviewed: August 03, 2011
The conclusions, findings, and opinions expressed by authors contributing to this journal do not necessarily reflect the official position of the U.S. Department of Health and Human Services, the Public Health Service, the Centers for Disease Control and Prevention, or the authors' affiliated institutions. Use of trade names is for identification only and does not imply endorsement by any of the groups named above.
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