Volume 18, Number 1—January 2012
CME ACTIVITY - Research
Accelerating Control of Pertussis in England and Wales
Helen Campbell
, Gayatri Amirthalingam, Nick Andrews, Norman K. Fry, Robert C. George, Timothy Harrison, and Elizabeth Miller
, Gayatri Amirthalingam, Nick Andrews, Norman K. Fry, Robert C. George, Timothy Harrison, and Elizabeth Miller
Table 1
Changes in reported incidence of pertussis during 4-year periods before and after introduction of a fourth dose of pertussis vaccine, by age group, England and Wales, 1998–2009*
| Age group and reporting mechanism | Reported incidence, by year† |
% Change per year, 1998–2009 (95% CI)‡ | ||
|---|---|---|---|---|
| 1998–2001 | 2002–2005 | 2006–2009 | ||
| <3 mo | ||||
| Laboratory reports | 98.59 | 75.23 | 67.25 | −4 (−9 to +1) |
| Notifications | 103.65 | 64.83 | 53.77 | −7 (−11 to −3) |
| Hospitalizations§ | 268.16 | 156.20 | 123.14 | −9 (−13 to −4) |
| 3–5 mo | ||||
| Laboratory reports | 26.12 | 17.06 | 15.09 | −6 (−11 to −2) |
| Notifications | 57.94 | 34.44 | 31.94 | −7 (−13 to −1) |
| Hospitalizations§ | 84.57 | 41.74 | 34.56 | −10 (−14 to −6) |
| 6–11 mo | ||||
| Laboratory reports | 4.73 | 2.60 | 1.69 | −11 (−17 to −5) |
| Notifications | 19.59 | 7.72 | 12.09 | −6 (−12 to +1) |
| Hospitalizations§ | 16.53 | 9.32 | 5.63 | −12 (−9 to −16) |
| 1–4 y | ||||
| Laboratory reports | 1.65 | 1.05 | 0.87 | −7 (−12 to −2) |
| Notifications | 13.16 | 5.13 | 6.00 | −9 (−16 to −2) |
| Hospitalizations§ | 5.62 | 2.32 | 0.88 | −19 (−23 to −16) |
| 5–9 y | ||||
| Laboratory reports | 0.98 | 0.98 | 0.81 | −3 (−7 to +2) |
| Notifications | 8.02 | 3.67 | 3.44 | −10 (−16 to −3) |
| Hospitalizations§ | 2.07 | 0.79 | 0.13 | −27 (−34 to −20) |
| 10–14 y | ||||
| Laboratory reports | 0.33 | 0.69 | 3.10 | +30 (+17 to +44) |
| Notifications | 2.19 | 1.79 | 4.90 | +9 (+1 to +19) |
| Hospitalizations§ | 0.49 | 0.27 | 0.39 | −3 (−11 to +4) |
| >15 y | ||||
| Laboratory | 0.02 | 0.18 | 0.82 | +53 (+43 to +63) |
| Notifications | 0.23 | 0.26 | 1.04 | +18 (+9 to +28) |
| Hospitalizations§ | 0.02 | 0.01 | 0.01 | −1 (−7 to +6) |
*Fourth dose introduced in October 2001.
†Rates per 100,000 population per year.
‡Calculated by linear regression analysis of the log of the annual incidence rate.
§Rates for England only.
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