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Volume 18, Number 10—October 2012


Hand, Foot, and Mouth Disease Caused by Coxsackievirus A6

Kelly Flett1, Ilan Youngster1, Jennifer Huang, Alexander McAdam, Thomas J. Sandora, Marcus Rennick, Sandra Smole, Shannon L. Rogers, W. Allan Nix, M. Steven Oberste, Stephen Gellis, and Asim A. AhmedComments to Author 
Author affiliations: Children’s Hospital Boston, Boston, Massachusetts, USA (K. Flett, I. Youngster, J. Huang, A. McAdam, T.J. Sandora, S. Gellis, A.A. Ahmed); Boston Public Health Commission, Boston (M. Rennick); Massachusetts Department of Public Health, Jamaica Plain, Massachusetts, USA (S. Smole); and Centers for Disease Control and Prevention, Atlanta, Georgia, USA (S.L. Rogers, W.A. Nix, M.S. Oberste)

Main Article


Demographic and clinical characteristics of patients with CVA6-associated HFMD, Boston, Massachusetts, USA, 2012*

Patient no. Age/sex Date treatment sought Tmax, °C URI Lesions
Specimen used for CVA6 diagnosis†
Perioral Intraoral Perirectal Hands/feet
1 12 mo/M Feb 15 39.8 No Yes No Yes Yes VF
2 10 mo/F Feb 2 38.2 Yes Yes Yes Yes Yes VF
3 8 mo/M Mar 1 39.1 No Yes No Yes No TS/RS
4 2 y/M Mar 1 38.4 Yes Yes Yes Yes Yes TS/RS
5 4 mo/F Feb 28 38.3 No Yes No No Yes VF
6 1.5 y/M Mar 16 39.4 Yes Yes No Yes No TS/RS
7 3 y/M Mar 8 38.0 Yes Yes Yes Yes Yes NP
8 15 mo/M Mar 7 39.5 No Yes Yes Yes Yes NP/RS

*CVA6, coxsackievirus A6; HFMD, hand, foot, and mouth disease; Tmax, maximum measured temperature; URI, upper respiratory infection, including symptoms of congestion or cough; RT-PCR, reverse transcription PCR; +, positive; VF, vesicular fluid; TS, throat swab; RS, rectal swab; NP, nasopharyngeal swab.
†Diagnosis was made by sequencing and analysis of the viral protein 1 coding region after RT-PCR.

Main Article

1These authors contributed equally to this article.