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Volume 18, Number 11—November 2012


Fatal Respiratory Infections Associated with Rhinovirus Outbreak, Vietnam

Le Thanh Hai, Vu Thi Ngoc Bich, Le Kien Ngai, Nguyen Thi Ngoc Diep, Phan Huu Phuc, Viet Pham Hung, Walter R. Taylor, Peter Horby, Nguyen Thanh Liem, and Heiman F.L. WertheimComments to Author 
Author affiliations: National Hospital of Pediatrics, Hanoi, Vietnam (L.T. Hai, L.K. Ngai, P.H. Phuc, V.P. Hung, N.T. Liem); Wellcome Trust Major Overseas Program Vietnam, Hanoi (V.T.N. Bich, N.T.N. Diep, W.R. Taylor, P. Horby, H.F.L. Wertheim); Oxford University Clinical Research Unit, Hanoi (W.R. Taylor, P. Horby, H.F.L. Wertheim); and University of Oxford, Oxford, UK (W.R. Taylor, P. Horby, H.F.L. Wertheim)

Main Article


Detected viruses in respiratory specimens from hospitalized children, children at the outbreak orphanage, and children from the control orphanage, Hanoi, Vietnam, December 2007–February 2008*

Viral diagnosis† Outbreak orphanage infants
Control orphanage infants
No. (%) hospitalized, n = 12 No. (%) not hospitalized, n = 43 No. (%) not hospitalized, n = 40
Single infection


10 (83.3) 19 (44.2) 4 (10.0)


0 0 6 (15.0)


0 2 (4.7) 0
Co-infection, 2 pathogens

Rhinovirus and adenovirus

0 2 (4.7) 4 (10.0)

Rhinovirus and RSV

0 4 (9.3) 1 (2.5)

Rhinovirus and parainfluenzavirus

0 1 (2.3) 0
Co-infection, 3 pathogens

Rhinovirus, adenovirus, and RSV

2 0 0
Any rhinovirus 12 (100) 26 (60.5) 9 (22.5)‡

*RSV, respiratory syncytial virus.
†By multiplex reverse transcription PCR (Seeplex RV12; Seegene, Seoul, South Korea).
‡χ2 test p = 0.0005

Main Article