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Volume 18, Number 12—December 2012

Research

Nonprimate Hepaciviruses in Domestic Horses, United Kingdom

Sinéad Lyons, Amit Kapoor, Colin Sharp, Bradley S. Schneider, Nathan D. Wolfe, Geoff Culshaw, Brendan Corcoran, Bruce C. McGorum, and Peter SimmondsComments to Author 
Author affiliations: Author affiliations: University of Edinburgh, Edinburgh, Scotland, UK (S. Lyons, C. Sharp, G. Culshaw, B. Corcoran, B.C. McGorum, P. Simmonds); Columbia University, New York, New York, USA (A. Kapoor); Global Viral Forecasting Initiative, San Francisco, California, USA (B.S. Schneider, N.D. Wolfe)

Main Article

Figure

Phylogenetic analysis of A) 5′ untranslated region, B) nonstructural protein 3, and C) nonstructural protein 5B regions of nonprimate hepatitis virus sequence amplified from screen-positive study animals. Neighbor-joining trees of nucleotide sequences from each genome region were constructed from Jukes-Cantor corrected pairwise distances calculated by using the program MEGA version 5 (25; datasets were bootstrap re-sampled 500× to indicate robustness of branching (values >70% shown on branche

Figure. . . Phylogenetic analysis of A) 5′ untranslated region, B) nonstructural protein 3, and C) nonstructural protein 5B regions of nonprimate hepatitis virus sequence amplified from screen-positive study animals. Neighbor-joining trees of nucleotide sequences from each genome region were constructed from Jukes-Cantor corrected pairwise distances calculated by using the program MEGA version 5 (25; datasets were bootstrap re-sampled 500× to indicate robustness of branching [values >70% shown on branches]). The hepacivirus genotype 1a sequence, M62321, was used to root the tree (not shown). Scale bars indicate nucleotide substitutions per site.

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References
  1. Jacobson  IM, Davis  GL, El-Serag  H, Negro  F, Trépo  C. Prevalence and challenges of liver diseases in patients with chronic hepatitis C virus infection. Clin Gastroenterol Hepatol. 2010;8:924–33. DOIPubMedGoogle Scholar
  2. Mühlberger  N, Schwarzer  R, Lettmeier  B, Sroczynski  G, Zeuzem  S, Siebert  U. HCV-related burden of disease in Europe: a systematic assessment of incidence, prevalence, morbidity, and mortality. BMC Public Health. 2009;9:34. DOIPubMedGoogle Scholar
  3. Simmonds  P, Bukh  J, Combet  C, Deléage  G, Enomoto  N, Feinstone  S, Consensus proposals for a unified system of nomenclature of hepatitis C virus genotypes. Hepatology. 2005;42:962–73. DOIPubMedGoogle Scholar
  4. Ruggieri  A, Argentini  C, Kouruma  F, Chionne  P, D’Ugo  E, Spada  E, Heterogeneity of hepatitis C virus genotype 2 variants in West Central Africa (Guinea Conakry). J Gen Virol. 1996;77:2073–6. DOIPubMedGoogle Scholar
  5. Jeannel  D, Fretz  C, Traore  Y, Kohdjo  N, Bigot  A, Pê Gamy  E, Evidence for high genetic diversity and long-term endemicity of hepatitis C virus genotypes 1 and 2 in West Africa. J Med Virol. 1998;55:92–7. DOIPubMedGoogle Scholar
  6. Candotti  D, Temple  J, Sarkodie  F, Allain  JP. Frequent recovery and broad genotype 2 diversity characterize hepatitis C virus infection in Ghana, West Africa. J Virol. 2003;77:7914–23. DOIPubMedGoogle Scholar
  7. Ndjomou  J, Pybus  OG, Matz  B. Phylogenetic analysis of hepatitis C virus isolates indicates a unique pattern of endemic infection in Cameroon. J Gen Virol. 2003;84:2333–41. DOIPubMedGoogle Scholar
  8. Smith  DB, Pathirana  S, Davidson  F, Lawlor  E, Power  J, Yap  PL, The origin of hepatitis C virus genotypes. [</jrn>]. J Gen Virol. 1997;78:321–8.PubMedGoogle Scholar
  9. Tokita  H, Okamoto  H, Tsuda  F, Song  P, Nakata  S, Chosa  T, Hepatitis C virus variants from Vietnam are classifiable into the seventh, eighth, and ninth major genetic groups. Proc Natl Acad Sci U S A. 1994;91:11022–6. DOIPubMedGoogle Scholar
  10. Pybus  OG, Drummond  AJ, Nakano  T, Robertson  BH, Rambout  A. The epidemiology and iatrogenic transmission of hepatitis C virus in Egypt: a Bayesian coalescent approach. Mol Biol Evol. 2003;20:381–7. DOIPubMedGoogle Scholar
  11. Frank  C, Mohamed  MK, Strickland  GT, Lavanchy  D, Arthur  RR, Magder  LS, The role of parenteral antischistosomal therapy in the spread of hepatitis C virus in Egypt. Lancet. 2000;355:887–91. DOIPubMedGoogle Scholar
  12. Shepard  CW, Finelli  L, Alter  MJ. Global epidemiology of hepatitis C virus infection. Lancet Infect Dis. 2005;5:558–67. DOIPubMedGoogle Scholar
  13. Magiorkinis  G, Magiorkinis  E, Paraskevis  D, Ho  SYW, Shapiri  B, Pybus  OG, The global spread of hepatitis C virus 1a and 1b: a phylodynamic and phylogeographic analysis. PLoS Med. 2009;6:e1000198. DOIPubMedGoogle Scholar
  14. Pybus  OG, Cochrane  A, Holmes  EC, Simmonds  P. The hepatitis C virus epidemic among injecting drug users. Infect Genet Evol. 2005;5:131–9. DOIPubMedGoogle Scholar
  15. Gao  F, Bailes  E, Robertson  DL, Chen  Y, Rodenburg  CM, Michael  SF, Origins of HIV-1 in the chimpanzee Pan troglodytes troglodytes. Nature. 1999;397:436–41. DOIPubMedGoogle Scholar
  16. Bailes  E, Gao  F, Bibollet-Ruche  F, Courgnaud  V, Peeters  M, Marx  PA, Hybrid origin of SIV in chimpanzees. Science. 2003;300:1713. DOIPubMedGoogle Scholar
  17. Makuwa  M, Souquiere  S, Telfer  P, Leroy  E, Bourry  O, Rouquet  P, Occurrence of hepatitis viruses in wild-born non-human primates: a 3 year (1998–2001) epidemiological survey in Gabon. J Med Primatol. 2003;32:307–14. DOIPubMedGoogle Scholar
  18. Makuwa  M, Souquiere  S, Telfer  P, Bourry  O, Rouquet  P, Kazanji  M, Hepatitis viruses in non-human primates. J Med Primatol. 2006;35:384–7. DOIPubMedGoogle Scholar
  19. Bukh  J. Hepatitis C homolog in dogs with respiratory illness. Proc Natl Acad Sci U S A. 2011;108:12563–4. DOIPubMedGoogle Scholar
  20. Simons  JN, Pilot-Matias  TJ, Leary  TP, Dawson  GJ, Desaib  SM, Schlauder  GG, Identification of two flavivirus-like genomes in the GB hepatitis agent. Proc Natl Acad Sci U S A. 1995;92:3401–5. DOIPubMedGoogle Scholar
  21. Muerhoff  AS, Leary  TP, Simons  JN, Pilot-Matias  TJ, Dawson  GJ, Erker  JC, Genomic organization of GB viruses A and B: two new members of the Flaviviridae associated with GB agent hepatitis. [</jrn>]. J Virol. 1995;69:5621–30.PubMedGoogle Scholar
  22. Kapoor  A, Simmonds  P, Gerold  G, Qaisar  N, Jain  K, Henriquez  JA, Characterization of a canine homolog of hepatitis C virus. Proc Natl Acad Sci U S A. 2011;108:11608–13. DOIPubMedGoogle Scholar
  23. Burbelo  PD, Dubovi  EJ, Simmonds  P, Medina  JL, Henriquez  JA, Mishra  N, Serology-enabled discovery of genetically diverse hepaciviruses in a new host. J Virol. 2012;86:6171–8. DOIPubMedGoogle Scholar
  24. Simmonds  P. SSE: a nucleotide and amino acid sequence analysis platform. BMC Res Notes. 2012;5:50. DOIPubMedGoogle Scholar
  25. Tamura  K, Peterson  D, Peterson  N, Stecherv  G, Nei  M, Kumar  S. MEGA5: Molecular Eevolutionary Genetics Aanalysis using maximum likelihood, evolutionary distance, and maximum parsimony methods. Mol Biol Evol. 2011;28:2731–9. DOIPubMedGoogle Scholar
  26. Bukh  J, Apgar  CL, Govindarajan  S, Emerson  SU, Purcell  RH. Failure to infect rhesus monkeys with hepatitis C virus strains of genotypes 1a, 2a or 3a. J Viral Hepat. 2001;8:228–31. DOIPubMedGoogle Scholar
  27. Bukh  J, Apgar  CL, Govindarajan  S, Purcell  RH. Host range studies of GB virus-B hepatitis agent, the closest relative of hepatitis C virus, in New World monkeys and chimpanzees. J Med Virol. 2001;65:694–7. DOIPubMedGoogle Scholar
  28. Beames  B, Chavez  D, Lanford  RE. GB virus B as a model for hepatitis C virus. [PubMed] [</jrn>]. ILAR J. 2001;42:152–60 http://dels-old.nas.edu/ilar_n/ilarjournal/42_2/Hep-GB-Virus.pdf.PubMedGoogle Scholar
  29. Ishii  K, Iijima  S, Kimura  N, Lee  YJ, Ageyama  N, Yagi  S, GBV-B as a pleiotropic virus: distribution of GBV-B in extrahepatic tissues in vivo. Microbes Infect. 2007;9:515–21. DOIPubMedGoogle Scholar
  30. Iwasaki  Y, Mori  K, Ishii  K, Maki  N, Iijima  S, Yoshida  T, Long-term persistent GBV-B infection and development of a chronic and progressive hepatitis C–like disease in marmosets. Front Microbiol. 2011;2:240. Epub 2011 Dec 7.PubMedGoogle Scholar
  31. Klenerman  P, Thimme  R. T cell responses in hepatitis C: the good, the bad and the unconventional. Gut. 2012;61:1226–34. DOIPubMedGoogle Scholar
  32. Guidotti  LG, Chisari  FV. Immunobiology and pathogenesis of viral hepatitis. Annu Rev Pathol. 2006;1:23–61. DOIPubMedGoogle Scholar

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