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Volume 18, Number 2—February 2012
Commentary

1918 Influenza, a Puzzle with Missing Pieces

David M. MorensComments to Author  and Jeffery K. Taubenberger
Author affiliations: National Institutes of Health, Bethesda, Maryland, USA

Main Article

Figure

Combined influenza plus pneumonia (P&I) age-specific incidence, mortality, and case-fatality rates, per 1,000 persons/age group, US Public Health Service house-to-house surveys, 8 states, 1918, and US Public Health Service surveys during 1928–1929. A) P&I incidence for 1918; B) mortality rate for 1918 (ill and well persons combined); C) P&I case-fatality rates for 1918 (solid line) compared with a more typical curve of age-specific influenza case-fatality rates (dotted line) from 192

Figure. Combined influenza plus pneumonia (P&I) age-specific incidence, mortality, and case-fatality rates, per 1,000 persons/age group, US Public Health Service house-to-house surveys, 8 states, 1918, and US Public Health Service surveys during 1928–1929. A) P&I incidence for 1918; B) mortality rate for 1918 (ill and well persons combined); C) P&I case-fatality rates for 1918 (solid line) compared with a more typical curve of age-specific influenza case-fatality rates (dotted line) from 1928–1929. Reprinted from (3).

Main Article

References
  1. Shanks  GD, Brundage  JF. Pathogenic responses among young adults during the 1918 influenza pandemic. Emerg Infect Dis. 2012 Feb. Epub 2012 Jan 4.
  2. Morens  DM, Taubenberger  JK, Fauci  AS. The persistent legacy of the 1918 influenza virus. N Engl J Med. 2009;361:2259. DOIPubMed
  3. Taubenberger  JK, Morens  DM. 1918 influenza: the mother of all pandemics. Emerg Infect Dis. 2006;12:1522.PubMed
  4. Morens  DM, Taubenberger  JK. Pandemic influenza: certain uncertainties. Rev Med Virol. 2011 Jun 27. Epub ahead of print. DOIPubMed
  5. Morens  DM, Taubenberger  JK, Fauci  AS. Predominant role of bacterial pneumonia as a cause of death in pandemic influenza: implications for pandemic influenza preparedness. J Infect Dis. 2008;198:96270. DOIPubMed
  6. Chien  Y-W, Klugman  KP, Morens  DM. Efficacy of whole-cell killed bacterial vaccines in preventing pneumonia and death during the 1918 influenza pandemic. J Infect Dis. 2010;202:163948. DOIPubMed
  7. Sheng  Z-M, Chertow  DS, Ambroggio  X, McCall  S, Przygodzki  RM, Cunningham  RE, Autopsy series of 68 cases dying before and during the 1918 influenza pandemic peak: virological and pathological findings. Proc Natl Acad Sci U S A. 2011;108:1641621. DOIPubMed
  8. Jordan  E. Epidemic influenza: a survey. Chicago: American Medical Association; 1927.

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Page created: January 18, 2012
Page updated: January 18, 2012
Page reviewed: January 18, 2012
The conclusions, findings, and opinions expressed by authors contributing to this journal do not necessarily reflect the official position of the U.S. Department of Health and Human Services, the Public Health Service, the Centers for Disease Control and Prevention, or the authors' affiliated institutions. Use of trade names is for identification only and does not imply endorsement by any of the groups named above.
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