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Volume 18, Number 2—February 2012
Dispatch

Multiorgan Dysfunction Caused by Travel-associated African Trypanosomiasis

Lucy E. CottleComments to Author , Joanna R. Peters1, Alison Hall, J. Wendi Bailey, Harry A. Noyes, Jane E. Rimington, Nicholas J. Beeching, S. Bertel Squire, and Mike B.J. Beadsworth
Author affiliations: Royal Liverpool University Hospital, Liverpool, UK (L.E. Cottle, J.R. Peters, A. Hall, N.J. Beeching, S.B. Squire, M.B.J. Beadsworth); Liverpool School of Tropical Medicine, Liverpool (J.W. Bailey, N.J. Beeching, S.B. Squire, M.B.J. Beadsworth); University of Liverpool, Liverpool (H.A. Noyes); Hawkshead Medical Practice, Ambleside, UK (J.E. Rimington)

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Table 2

Reports to ProMED-mail of Trypanosoma brucei rhodesiense infections associated with travel to or bordering Zambia, 2010*

Month of report ProMED-mail archive no. Nationality of patient Travel activity Area visited
September 20100915.3338 Zambian Visiting game ranch South Luangwa Valley, Zambia
20100915.3338 American Hunting safari South Luangwa Valley, Zambia
October† 20101022.3833 British Camping safari South Luangwa National Park, Lower Zambez National Park, Kafu National Park, Zambia
20101022.3833 British Visiting national park Mana Pool National Park, Zimbabwe (bordering Zambia)
November 20101111.4093 South African national of Scandinavian origin Hiking Luangwa River area, Zambia

*Reports in (6). Since the start of 2005, 11 other cases of T. b. rhodesiense infection in travelers have been reported in ProMED-mail; those cases were acquired in Uganda (1), Tanzania (3), and Malawi (7).
†Case presented in this report.

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References
  1. Welburn  SC, Picozzi  K, Fèvre  EM, Coleman  PG, Odiit  M, Carrington  M, Identification of human-infective trypanosomes in animal reservoir of sleeping sickness in Uganda by means of serum-resistance-associated (SRA) gene. Lancet. 2001;358:2017–9. DOIPubMedGoogle Scholar
  2. Brun  R, Blum  J, Chappuis  F, Burri  C. Human African trypanosomiasis. Lancet. 2010;375:148–59. DOIPubMedGoogle Scholar
  3. Abramowicz  M. Drugs for parasitic infections. In: Abramowicz M, editor. The medical letter on drugs and therapeutics. New Rochelle (NY): The Medical Letter, Inc; 2000. p. 1–12.
  4. Kennedy  PG. The continuing problem of human African trypanosomiasis (sleeping sickness). Ann Neurol. 2008;64:116–26. DOIPubMedGoogle Scholar
  5. Gautret  P, Clerinx  J, Caumes  E, Simon  F, Jensenius  M, Loutan  L, Imported human African trypanosomiasis in Europe, 2005–2009. Euro Surveill. 2009;14:pii:19327. PubMedGoogle Scholar
  6. ProMED-mail. Archive nos. 20100915.3338, 20101022.3833, and 20101111.4093 [cited 2011 Sep 22]. http://www.promedmail.org
  7. Sinha  A, Grace  C, Alston  WK, Westenfeld  F, Maguire  JH. African trypanosomiasis in two travelers from the United States. Clin Infect Dis. 1999;29:840–4. DOIPubMedGoogle Scholar
  8. Reincke  M, Arlt  W, Heppner  C, Petzke  F, Chrousos  GP, Allolio  B. Neuroendocrine dysfunction in African trypanosomiasis. Ann N Y Acad Sci. 1998;840:809–21. DOIPubMedGoogle Scholar
  9. Burri  C. Chemotherapy against human African trypanosomiasis: is there a road to success? Parasitology. 2010;137:1987–94. DOIPubMedGoogle Scholar
  10. Rodgers  J. Human African trypanosomiasis, chemotherapy and CNS disease. J Neuroimmunol. 2009;211:16–22. DOIPubMedGoogle Scholar
  11. World Health Organization. Control and surveillance of African trypanosomiasis. Report of a WHO expert committee. WHO Technical Report Series. 1998;881:I–VI, 1–114.
  12. Vanhamme  L, Paturiaux-Hanocq  F, Poelvoorde  P, Nolan  DP, Lins  L, Van Den Abbeele  J, Apolipoprotein L–I is the trypanosome lytic factor of human serum. Nature. 2003;422:83–7. DOIPubMedGoogle Scholar
  13. Pays  E, Vanhollebeke  B. Human innate immunity against African trypanosomes. Curr Opin Immunol. 2009;21:493–8. DOIPubMedGoogle Scholar
  14. Vanhollebeke  B, Truc  P, Poelvoorde  P, Pays  A, Joshi  PP, Katti  R, Human Trypanosoma evansi infection linked to a lack of apolipoprotein L–I. N Engl J Med. 2006;355:2752–6. DOIPubMedGoogle Scholar

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1Current affiliation: Worthing Hospital, Worthing, UK.

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