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Volume 18, Number 2—February 2012
Research

Pathogenesis of Avian Bornavirus in Experimentally Infected Cockatiels

Anne K. PiepenbringComments to Author , Dirk Enderlein, Sibylle Herzog, Erhard F. Kaleta, Ursula Heffels-Redmann, Saskia Ressmeyer, Christiane Herden, and Michael Lierz
Author affiliations: Justus Liebig University Giessen, Giessen, Germany

Main Article

Table 2

Postmortem findings in cockatiels experimentally infected with ABV*

Bird Died, dpi Euthanized, dpi Antibody titer† Dilatation of proventriculus‡ Antigen detection§
 Infectious virus¶
p14 p24
ic1 10,240 2 + + +
ic2 – 206 5,120 3 + + +
ic3 – 60 20,480 1 + + +
ic4 – 115 20,480 0 + + +
ic5 – 115 20,480 0 + + +
ic6 – 230 5,120 0 + + +
ic7 66 – 1,0240 0 + + +
ic8 – 230 1,0240 0 + + +
ic9 – 115 5,120 0 + + +
iv1 – 230 10,240 2 + + +
iv2 – 229 5,120 2 + + +
iv3 120 – 10,240 2 + − +
iv4 – 116 5,120 1 + + +
iv5 – 116 20,480 0 + + +
iv6 – 229 10,240 0 + + +
iv7 – 229 10,240 0 + + +
iv8 – 116 5,120 0 + + +
iv9 – 229 20,480 0 + + +
se1 – 229 <10 0 − − −

*Proventricular dilatation disease was confirmed in all birds by histopathologic confirmation of lymphoplasmacytic infiltrates of/near ganglia in the central nervous system and/or upper gastrointestinal tract. ABV, avian bornavirus; dpi, days postinoculation; ic, intracerebrally inoculated; +, positive; −, negative; iv, intravenously inoculated; se, sentinel.
†Antibodies against avian bornavirus detected by use of indirect immunofluorescence assay; titers <10.0 are considered negative.
‡0, no dilatation; 1, mild dilatation; 2, moderate dilatation; 3, severe dilatation.
§Detection of the X-protein (p14) and the phosphoprotein (p24) of Borna disease virus by immunohistochemical testing.
¶Re-isolation of infectious ABV in quail cell line CEC-32.

Main Article

Page created: January 17, 2012
Page updated: January 17, 2012
Page reviewed: January 17, 2012
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