Volume 18, Number 4—April 2012
Research
Identification of Risk Factors for Chronic Q Fever, the Netherlands
Table 1
Classification | Definition |
---|---|
Proven | Any of the following: |
Positive PCR for Coxiella burnetii in serum, plasma, or tissue in the absence of acute Q fever | |
IFA phase I titer ≥1,024 with definite endocarditis according to the revised Duke criteria (21) | |
Indication of vascular infection on PET/CT, CT, MRI, or ultrasound testing | |
Probable | IFA phase I IgG titer >1,024 and any of the following clinical manifestations: |
Valvulopathy not meeting the criteria of endocardial involvement of the major modified Duke criteria (22) | |
Aneurysm, vascular prosthesis or prosthetic valve without signs of infection on PET/CT, CT, MRI, or ultrasound testing | |
Signs of possible chronic Q fever infection of noncardiac or vascular origin on PET/CT, CT, or ultrasound testing | |
Pregnancy | |
Clinical symptoms of chronic infection (i.e., fever, night sweats, weight loss, hepatosplenomegaly) | |
Histopathologic proven granulomatous inflammation | |
Immune disorder | |
Possible | IFA phase I IgG titer >1,024 without clinical manifestations as described above |
*Described in (20). IFA, immunofluorescence assay; PET, positron emission tomography; CT, computed tomography; MRI, magnetic resonance imaging.
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