Volume 18, Number 5—May 2012
No Association between 2008–09 Influenza Vaccine and Influenza A(H1N1)pdm09 Virus Infection, Manitoba, Canada, 2009
|Variable||No. community controls, n = 2,479||No. community case-patients, n = 626||Odds ratio (95% CI)
|Model A†||Model B‡||Model C§|
|2007–08||544||123||0.9 (0.7–1.1)||1.3 (1.0–1.7)||1.4 (1.0–1.9)|
|2008–09||564||109||0.7 (0.6–0.9)||1.1 (0.8–1.4)||1.0 (0.7–1.4)|
|2007–08 only||187||51||1.0 (0.7–1.4)||1.3 (0.9–1.8)||1.3 (0.9–1.9)|
|2008–09 only||207||37||0.7 (0.5–1.0)||0.9 (0.6–1.3)||0.9 (0.6–1.4)|
|Both||357||72||0.7 (0.6–1.0)||1.3 (0.9–1.8)||1.4 (1.0–2.0)|
|No. TIVs in past 5 y|
|At least 1||1,029||243||0.9 (0.7–1.1)||1.2 (1.0–1.5)||1.2 (1.0–1.5)|
|1–3||711||187||1.0 (0.8–1.2)||1.2 (0.9–1.5)||1.2 (0.9–1.5)|
|4–5||318||56||0.7 (0.5–0.9)||1.3 (0.9–1.9)||1.4 (1.0–2.2)|
|5||156||19||0.5 (0.3–0.8)||0.8 (0.4–1.4)||0.8 (0.4–1.4)|
|Ever received PPV23||343||41||0.4 (0.3–0.6)||0.9 (0.6–1.4)||0.9 (0.6–1.5)|
|2008–09 TIV only||340||86||0.9 (0.7–1.2)||1.1 (0.8–1.4)||1.0 (0.7–1.4)|
|PPV23 only||119||18||0.5 (0.3–0.9)||0.9 (0.5–1.5)||0.9 (0.5–1.6)|
|Both||224||23||0.4 (0.2–0.6)||1.0 (0.6–1.7)||1.0 (0.5–1.8)|
*TIV, inactivated trivalent influenza vaccine; PPV23, pneumococcal polysaccharide vaccine.
‡Model adjusted for age, sex, region of residence, Socioeconomic Factor Index (24), and week of specimen collection.
§Model adjusted for all model B variables plus no. of hospital admissions and family physician visits in previous 12 mo, pregnancy, having a chronic or immunocompromising medical condition, and antiviral drug use. Model also included mutual adjustment for 2007–09 TIV and PPV23.
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