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Volume 18, Number 5—May 2012


Hepatitis E Virus Infection among Solid Organ Transplant Recipients, the Netherlands

Suzan D. Pas, Rob A. de Man, Claudia Mulders, Aggie H.M.M. Balk, Peter T.W. van Hal, Willem Weimar, Marion P.G. Koopmans, Albert D.M.E. Osterhaus, and Annemiek A. van der EijkComments to Author 
Author affiliations: Erasmus Medical Center, Rotterdam, the Netherlands

Main Article

Table 2

Parameters in chronic HEV infections among SOT recipients, the Netherlands, 2000–2011*

Parameter Median Range ULN (F/M)
Peak alanine aminotransferase, U/L 301 81–909 30/40
Peak aspartate aminotransferase, U/L 172 66–1016 30/36
Peak gamma-glutamil transferase, U/L 299 72–1740 34/49
Peak bilirubin, μmol/L 16 5–100 16/16
Peak HEV RNA, cycle threshold values 20.0 16.7–26.6 NA
Period of HEV RNA positivity, mo 16 6–55 NA
Time between SOT and first HEV RNA–positive result, mo 2.0 –0.3 to 20.1 NA
Time of HEV RNA positivity before HEV IgM positive, d 32 0–826 NA
Time of HEV RNA positivity before HEV IgG positive, d 124 0–826 NA

*HEV, hepatitis E virus; SOT, solid organ transplant; ULN (F/M), upper limit of normal (female/male); NA, not applicable.

Main Article