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Volume 18, Number 9—September 2012
Dispatch

Rapid Detection of Carbapenemase-producing Enterobacteriaceae

Patrice NordmannComments to Author , Laurent Poirel, and Laurent Dortet
Author affiliations: Faculté de Médecine Paris Sud, Le Kremlin-Bicêtre, France (P. Nordmann, L. Poirel, L. Dortet); and Institut National de la Santé et de la Recherche Médicale, Paris, France (P. Nordmann, L. Poirel, L. Dortet)

Main Article

Table 2

Non–carbapenemase-producing clinical enterobacterial isolates subjected to the Carba NP test*

β-Lactamase type, species β-Lactamase No. MIC, mg/L
Carba NP test result
IMP ERT MER
ESBLs
Klebsiella pneumoniae CTX-M-3 1 0.12 0.12 0.12
CTX-M-14 1 0.12 0.12 0.12
CTX-M-15 3 0.12 0.12 0.12
Escherichia coli CTX-M-1 1 0.12 0.12 0.12
CTX-M-3 1 0.12 0.12 0.12
CTX-M-14 2 0.12 0.12 0.12
CTX-M-15 2 0.12 0.12 0.12
VEB-1 1 0.12–0.25 0.12 0.12
Enterobacter cloacae CTX-M-15 3 0.12 0.12 0.12

VEB-1
1
0.12
0.12
0.12

Plasmid-mediated AmpC or chromosomal AmpC + decreased membrane permeability
K. pneumoniae DHA-1 1 >32 >32 >32
DHA-2 1 0.12 0.5 0.12
E. coli Extended-spectrum cephalosporinase 1 0.12 0.12 0.12
CMY-2 1 0.12 0.12 0.12
CMY-10 1 0.12 0.38 0.12
DHA-1 1 0.12 0.12 0.12
ACC-1 1 0.12 0.12 0.12
Overexpressed cephalosporinase 1 16 >32 2
Proteus mirabilis ACC-1 1 0.25 0.12 0.12
E. cloacae Overexpressed cephalosporinase 7 0.12–16 1–>32 0.12–>32
Enterobacter aerogenes Overexpressed cephalosporinase 1 1 4 0.75
Morganella morganii
Overexpressed cephalosporinase
2
1.5–2
0.12
0.5

ESBL + decreased membrane permeability
K. pneumoniae CTX-M-15 8 0.25–8 1–>32 1–>32
SHV-28 1 1 4 1
SHV-2a 1 0.25 2 0.38
Enterobacter sakazakii CTX-M-15 1 0.25 1.5 0.25
Citrobacter freundii TEM-3 1 1 8 1

*IMP, imipenem; ERT, ertapenem; MER, meropenem; ESBLs, extended-spectrum β-lactamases.

Main Article

Page created: August 27, 2012
Page updated: August 27, 2012
Page reviewed: August 27, 2012
The conclusions, findings, and opinions expressed by authors contributing to this journal do not necessarily reflect the official position of the U.S. Department of Health and Human Services, the Public Health Service, the Centers for Disease Control and Prevention, or the authors' affiliated institutions. Use of trade names is for identification only and does not imply endorsement by any of the groups named above.
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