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Volume 19, Number 1—January 2013
Dispatch
Klebsiella pneumoniae Antimicrobial Drug Resistance, United States, 1998–2010
Guillermo V. Sanchez, Ronald N. Master, Richard B. Clark, Madiha Fyyaz, Padmaraj Duvvuri, Gupta Ekta, and Jose Bordon
Table 1
Klebsiella pneumoniae antimicrobial drug resistance among inpatients, by year, United States, 1998–2010*
| Antimicrobial drug | No. | 1998 | 1999 | 2000 | 2001 | 2002 | 2003 | 2004 | 2005 | 2006 | 2007 | 2008 | 2009 | 2010 | Total change† |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| TET | 80,862 | 14.2 | 14.7 | 14.6 | 13.9 | 14.2 | 13 | 15.6 | 14.8 | 15.6 | 15.2 | 15.3 | 16.4 | 16.7 | 2.5 |
| AMK | 232,933 | 0.7 | 0.9 | 0.8 | 0.9 | 1 | 1.1 | 2.1 | 3.7 | 4.9 | 4.6 | 4.9 | 4.6 | 4.5 | 3.8 |
| IPM | 259,589 | 0 | 0 | 0 | 0 | 0 | 0 | 0.3 | 0.6 | 0.6 | 1.5 | 3.3 | 3.8 | 4.3 | 4.3 |
| GEN | 344,597 | 4.9 | 4.6 | 4.6 | 5.2 | 5.5 | 5.6 | 6.9 | 8.3 | 8.4 | 7.8 | 8.7 | 9.1 | 9.2 | 4.3 |
| CPM | 211,134 | 2.1 | 2 | 2.7 | 2.3 | 2.3 | 2.5 | 5.1 | 5.3 | 5.5 | 5.8 | 7.7 | 7.3 | 7.7 | 5.6 |
| TMP/SXT | 344,522 | 10.9 | 11 | 10.9 | 10.4 | 10.4 | 10.9 | 13 | 15 | 16.2 | 16.5 | 19.4 | 18.9 | 19.3 | 8.4 |
| TZP | 250,554 | 4 | 5.5 | 5.4 | 5.3 | 5.3 | 5.6 | 7.7 | 8.8 | 8.4 | 7.8 | 10.5 | 12 | 12.7 | 8.7 |
| TOB | 289,287 | 4.6 | 4.5 | 4.4 | 4.8 | 5.2 | 5.5 | 8 | 9.8 | 11.9 | 10.4 | 13.2 | 13.2 | 13.8 | 9.2 |
| CRO | 287,091 | 1.8 | 2.7 | 3.2 | 2.9 | 2.6 | 3.1 | 5.7 | 6.9 | 8.1 | 8.7 | 11.1 | 11.2 | 12.1 | 10.3 |
| CIP | 306,348 | 5.5 | 6.1 | 6.5 | 7 | 7.6 | 7.9 | 9.9 | 11.7 | 14.4 | 14.6 | 17 | 16.8 | 16.8 | 11.3 |
| CAZ | 248,004 | 5.5 | 6.8 | 7.9 | 7.9 | 7.7 | 7.8 | 11.3 | 13.3 | 12.3 | 12.3 | 15.6 | 15.2 | 17.2 | 11.7 |
| ATM | 184,981 | 7.7 | 7.7 | 7.7 | 7.5 | 8 | 7.3 | 11.2 | 12.9 | 12.8 | 12.8 | 16.6 | 16.1 | 22.2 | 14.5 |
*TET, tetracycline; AMK, amikacin; IPM, imipenem; GEN, gentamicin; CPM, cefepime; TMP/SXT, trimethoprim/sulfamethoxazole; TZP, piperacillin/tazobactam; TOB, tobramycin; CRO, ceftriaxone; CIP, ciprofloxacin; CAZ, ceftazidime; ATM, aztreonam.
†Change from 1998 to 2010. p<0.0001 for all antimicrobial agents except tetracycline (p = 0.0745).
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- Page last updated: December 20, 2012
- Page last reviewed: December 20, 2012
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