Volume 19, Number 10—October 2013
CME ACTIVITY - Research
Increased Incidence of Invasive Fusariosis with Cutaneous Portal of Entry, Brazil
Marcio Nucci
, Andrea G. Varon, Marcia Garnica, Tiyomi Akiti, Gloria Barreiros, Beatriz Moritz Trope, and Simone A. Nouér
, Andrea G. Varon, Marcia Garnica, Tiyomi Akiti, Gloria Barreiros, Beatriz Moritz Trope, and Simone A. Nouér
Table
Characteristics of 21 patients with invasive fusariosis in the hematology united at University Hospital, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil, 2000–2010*
| Characteristic | Patients |
|---|---|
| Sex, M:F | 16:5 |
| Median age, y (range) |
55 (9–71) |
| Underlying disease | |
| Acute myeloid leukemia | 9 (42.9) |
| Multiple myeloma | 4 (19.0) |
| Non-Hodgkin lymphoma | 2 (9.5) |
| Acute lymphoid leukemia | 2 (9.5) |
| Myelodysplasia | 2 (9.5) |
| Aplastic anemia | 1 (4.8) |
| Chronic myeloid leukemia |
1 (4.8) |
| HCT recipients | 12 (57.1) |
| Allogeneic | 8 (38.1) |
| Autologous |
4 (19.0) |
| Room with HEPA filter | 14 (66.7) |
| Receipt of corticosteroids |
16 (76.2) |
| Graft-versus-host disease, n = 8† | 6 (75.0) |
| Neutropenia | 17 (81.0) |
| Skin as portal of entry | 17 (81.0) |
| Positive blood culture |
11 (52.4) |
| Classification of fusariosis | |
| Proven | 20 (95.2) |
| Probable |
1 (4.8) |
| Primary treatment | |
| None | 1 (4.8) |
| Voriconazole | 7 (33.3) |
| Deoxycholate amphotericin B | 10 (47.6) |
| Deoxycholate amphotericin B + voriconazole | 3 (14.3) |
*Values are no. (%) patients except as indicated. HCT, hematopoietic cell transplant; HEPA, high-efficiency particulate air.
†Allogeneic HCT recipients.
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