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Volume 19, Number 10—October 2013


Human Infection with Eurasian Avian-like Influenza A(H1N1) Virus, China

Da-Yan Wang1, Shun-Xiang Qi1, Xi-Yan Li, Jun-Feng Guo, Min-Ju Tan, Guang-Yue Han, Yan-Fang Liu, Yu Lan, Lei Yang, Wei-Juan Huang, Yan-Hui Cheng, Xiang Zhao, Tian Bai, Zhao Wang, He-Jiang Wei, Ning Xiao, and Yue-Long ShuComments to Author 
Author affiliations: National Insititute for Viral Disease Control and Prevention, China CDC. Beijing, People’s Republic of China (D.-Y. Wang, X.-Y. Li, J.-F. Guo, M.-J. Tan, Y. Lan, L. Yang, W.-J. Huang, Y.-H. Cheng, X. Zhao, T. Bai, Z. Wang, N. Xiao, H.-J. Wei, Y.-L. Shu); Hebei Center for Disease Control and Prevention, Hebei Province, People’s Republic of China (S.-X. Qi, G.-Y. Han, Y.-F. Liu)

Main Article


Cross-reactive antibody response against avian-like influenza A(H1N1) virus in pediatric and adult recipients of seasonal trivalent inactivated influenza vaccines, China, 2013*†

group, y Antigen Increase ≥4, %‡ Geometric mean titer

%Titer ≥40

%Titer ≥160
Before vac. After vac. Before vac. After vac. Before vac. After vac.
Children, n = 25 A/California/7/2009 60.0 21.1 121.3 44.0 84.0 16.0 60.0
3–5 HB/1250/12 24.0 12.8 25.7 28.0 56.0 0 24.0
Adults, n = 30 A/California/7/2009 70.0 14.8 156.3 26.7 76.7 0 60.0
18–59 HB/1250/12 6.7 8.1 31.7 6.7 56.7 0 23.3
Elderly adults, n = 30 A/California/7/2009 46.7 10.5 52.8 10.0 53.3 0 30.0
>60 HB/1250/12 26.7 5.7 11.5 0 26.7 0 6.7

*Vac., vaccination.
†All children received 2 doses of vaccine with an interval of 1 month. The composition of the trivalent vaccine were A/Christchurch/16/2010(NIB-74xp) (A/California/7/2009-like), A/Victoria/361/2011 (H3N2)IVR-165, and B/Hubei-Wujiagang/158/2009. Serum samples were obtained from vaccine recipients living in northern (children) and southern (adults and elderly adults) China.
‡Increase in antibody titer.

Main Article

1These authors contributed equally to this article.