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Volume 19, Number 2—February 2013
CME ACTIVITY - Research

Laboratory-based Surveillance for Hepatitis E Virus Infection, United States, 2005–2012

Jan DrobeniucComments to Author , Tracy Greene-Montfort, Ngoc-Thao Le, Tonya R. Mixson-Hayden, Lilia Ganova-Raeva, Chen Dong, Ryan T. Novak, Umid M. Sharapov, Rania A. Tohme, Eyasu Teshale, Saleem Kamili, and Chong-Gee Teo
Author affiliations: Author affiliation: Centers for Disease Control and Prevention, Atlanta, GA, USA

Main Article

Table

Demographic, clinical, travel-related, and virologic characteristics for patients with hepatitis E, United States, 2005–2012*

Travel history and case-patient no. Age, y/sex Race/ ethnicity State of residence Transplant (organ) Jaundice Countries
visited Anti-HEV SCR
HEV genotype HEV
viral load†
IgM IgG
No recent international travel‡
NT1 61/M White FL No Yes NA 7.5 5.7 3 NA
NT2 45/M White CA No Yes NA 3.7 4
NT3 63/M White SD Yes (kidney) No NA 7.2 5.4 3 NA
NT4 61/M South Asian IL Yes (liver) No NA 1.9 5.9 3 NA
NT5 67/M White FL No Yes NA 6.3 1.3
NT6 44/F Hispanic TX No Yes§ NA 3.1 3.7 3 NA
NT7 21/F Hispanic TX No Yes¶ NA 2.2 1.6
NT8 67/M White IL Yes (heart and lungs) Yes NA 3 3.3
NT9 42/M White WI No Yes NA 6 6.6
NT10 62/F White IL Yes (kidney) No NA 2.9 8.9
NT11 26/M White PA Yes (kidney) No NA 5.3 8.3 3 7.8 × 102
NT12 40/F White NY Yes (kidney and pancreas) No# NA 7.7 12.9 3 1.4 × 103
NT13 64/M White CT Yes (liver) Yes NA 9.2 1.3 3 1.4 × 104
NT14 29/F White MI No No** NA 6.6 9.8
NT15
62/M
White
NY
No
No
NA
Neg
9.6
3
1.5 × 103
Recent international travel‡
T1 35/M South Asian DE No Yes India 2.3 4.5 1 1.8 × 102
T2 14/F South Asian TX No Yes India 7.3 5.8
T3 32/F South Asian TX No Yes India 3.7 5.8
T4 24/M South Asian TX No Yes India 2.3 2
T5 35/M White IL No No India and Indonesia 2.9 8.9
T6 24/M White MD No Yes Afghanistan and Dubai 6.9 9.4
T7 63/M White AL No Yes China 7.9 Neg 4 2.4 × 102
T8 23/M South Asian ME No­­ Yes Bangladesh 7.6 10.8
T9 53/M South Asian MD No Yes†† India 9.2 9.4
T10 66/M South Asian TX No Yes India 5.5 11.7 1 1.8 × 102
T11 22/M South Asian MD No Yes India 9.9 10.9 1 8.3 × 105

*HEV, hepatitis E virus; SCR, signal/cutoff ratio; NT, nontraveler; NA, not applicable (quantitative reverse transcription PCR not done); –, HEV not detected or genotype not tested; Neg, negative.
†In genome-equivalents/mL.
‡Within 2 mo before illness or visit to physician.
§Fulminant hepatic failure developed but resolved (14).
¶Fulminant hepatic failure developed; patient died at time of liver transplantation (14).
#Initial illness was meningitis.
**Asymptomatic; tested for HEV because of recent miscarriage.
††Fulminant hepatic failure developed, requiring liver transplantation; patient survived.

Main Article

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Page created: January 22, 2013
Page updated: January 22, 2013
Page reviewed: January 22, 2013
The conclusions, findings, and opinions expressed by authors contributing to this journal do not necessarily reflect the official position of the U.S. Department of Health and Human Services, the Public Health Service, the Centers for Disease Control and Prevention, or the authors' affiliated institutions. Use of trade names is for identification only and does not imply endorsement by any of the groups named above.
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