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Volume 19, Number 3—March 2013
Letter

Peritoneal Tuberculosis in a Pregnant Woman from Haiti, United States

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To the Editor: A 29-year-old woman at 23 weeks’ gestation during her first pregnancy came to our hospital’s obstetrics clinic after 6 days of vaginal bleeding and abdominal pain. She had not experienced fever, sweats, weight loss, contractions, or other symptoms. She was otherwise healthy; she was taking no medications, but was taking iron and multivitamin supplements. She had legally immigrated to the United States from Haiti 8 months previously and had no known tuberculosis contacts. Physical examination disclosed brown vaginal discharge and a closed cervix. Obstetric ultrasound was normal, and vaginal swab samples were negative for Neisseria gonorrhea and Chlamydia trachomatis.

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Thumbnail of T2-weighted magnetic resonance imaging sequence of the pregnant woman’s abdomen demonstrating an omental mass of intermediate intensity (white arrow) anterior to the uterus.

Figure. . . T2-weighted magnetic resonance imaging sequence of the abdomen of a pregnant woman from Haiti. An omental mass of intermediate intensity (white arrow) is shown anterior to the uterus.

Over the ensuing 2 weeks, her vaginal bleeding and abdominal pain worsened. She was admitted to the hospital. Physical examination revealed vaginal bleeding, but her condition was otherwise unchanged. Routine laboratory studies were normal. Repeat obstetric ultrasound showed a viable fetus, ascites, and a 15 × 15 × 3–cm rind of echogenic material anterior to the uterus. This abnormality was in the upper abdomen, an area not imaged on her previous ultrasound. Abdominal magnetic resonance imaging revealed moderate ascites and a 21 × 14 × 3–cm omental mass of intermediate intensity on T1 and T2 sequences; there was no lymphadenopathy (Figure). A tiny left pleural effusion was seen on chest radiograph. Routine HIV and tuberculin skin test results had been negative 4 months previously, and pre-immigration examination results and chest radiograph had been normal.

Fine-needle aspiration of the omental mass was nondiagnostic. The patient’s vaginal bleeding and abdominal pain persisted, and her cervix dilated. She had an oral temperature of 38.9° Celsius. Exploratory laparotomy demonstrated a friable omental mass with implants on the small bowel; a partial omentectomy was performed at 26 weeks’ gestation. During this procedure, the patient gave birth to a male infant.

Multiple granulomata, some containing acid-fast bacilli, were identified upon histologic examination of the momentum (Technical Appendix Figure). Transcription-mediated amplification of the specimen was positive for Mycobacterium tuberculosis rRNA; cultures later grew M. tuberculosis susceptible to all first-line antituberculosis medications. Sputum smears and cultures were not performed. The patient’s treatment began with isoniazid, rifampin, ethambutol, and pyrazinamide; her fevers and abdominal pain resolved. Her son was admitted to the neonatal intensive care unit and was placed on antimycobacterial therapy. He also recovered and was discharged after 135 days.

This case highlights several issues related to tuberculosis epidemiology and diagnosis. Although pulmonary disease is the most common manifestation of tuberculosis overall, extrapulmonary tuberculosis accounts for a significant and increasing proportion of cases in the United States (1). Pregnancy is associated with greater likelihood of extrapulmonary disease; extrapulmonary infection accounts for 13% of all cases worldwide (2) but 50% of cases in pregnancy, according to a recent study (3).

The frequency of peritoneal tuberculosis in pregnancy is unknown; few cases have been reported in the literature (47), although we know of 3 additional cases from Haiti (online Technical Appendix Table). However, cases are likely underdiagnosed or diagnosed late in the course of illness. Underdiagnosis and delayed diagnosis may be caused by the nonspecific nature of symptoms, commonly abdominal pain and ascites, which can be attributed to pregnancy itself or obstetrical complications. These erroneous explanations for symptoms are reflected in this patient, whose symptoms were initially attributed to abruption and who was not diagnosed with tuberculosis until >3 weeks after seeking medical assistance. Such delays in diagnosis are typical of peritoneal tuberculosis and are associated with increased death rates (8). In many cases, clinical features cannot distinguish peritoneal tuberculosis from malignancy, necessitating more extensive evaluation (7).

Failure to diagnose peritoneal tuberculosis, in pregnancy or otherwise, might also stem from the insensitivity of noninvasive diagnostic testing. Paracentesis with acid-fast staining detects only a minority of cases (8). The sensitivity of mycobacterial cultures of ascites fluid varies, and culture results are often not available for weeks (8). Ascites fluid adenosine deaminase has shown promise as a reliable, minimally invasive diagnostic test in resource-poor countries, but was insensitive in a United States study (9). In addition, although tuberculin skin testing and interferon gamma release assay performance are not affected by pregnancy (10), neither can distinguish active from latent infection. Without diagnostic clinical features or sensitive noninvasive tests, the diagnosis of peritoneal tuberculosis might only be confirmed through laparoscopy or laparotomy, as in our case. Such invasive testing methods and facilities, equipment, and personnel might not be readily available in resource-poor settings.

This case also illustrates the ongoing threat of tuberculosis in countries of all income levels. It is not clear where our patient contracted tuberculosis; she was most likely exposed in Haiti, but transmission within her Haitian community in the United States, or from another source, is also possible. Regardless, as in her case, a majority of tuberculosis cases within the United States occur in foreign-born persons. Given the ease and frequency of travel, lapses in tuberculosis control in any locale are likely to have effects more broadly. Wherever they work, clinicians must maintain vigilance for tuberculosis in all of its protean forms.

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Acknowledgment

The authors thank Walter Pieciak and Andrew Onderdonk for providing the molecular diagnostic testing used for this patient.

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Kevin L. ArdComments to Author , Brian T. Chan, Danny A. Milner, Paul E. Farmer, and Serena P. Koenig

Author affiliations: Affiliations: Brigham and Women’s Hospital, Boston, Massachusetts, USA (K.L. Ard, B.T. Chan, D.A. Milner Jr, P.E. Farmer, S.P. Koenig); Massachusetts General Hospital, Boston (K.L. Ard, B.T. Chan)

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References

  1. Albalak  R, O’Brien  RJ, Kammerer  JS, O'Brien  SM, Marks  SM, Castro  KG, Trends in tuberculosis/human immunodeficiency virus comorbidity, United States, 1993–2004. Arch Intern Med. 2007;167:244352. DOIPubMed
  2. World Health Organization. Global Tuberculosis Control: WHO Report 2011. 2011 [cited 2012 Dec 5]. http://www.who.int/tb/publications/global_report/2011/gtbr11_full.pdf.
  3. Knight  M, Kurinczuk  JJ, Nelson-Piercy  C, Spark  P, Brocklehurst  P. Tuberculosis in pregnancy in the UK. BJOG. 2009;116:5848. DOIPubMed
  4. Coden  J. Tuberculous peritonitis in pregnancy. BMJ. 1972;3:153. DOIPubMed
  5. Brooks  JH, Stirrat  GM. Tuberculous peritonitis in pregnancy. Case report. Br J Obstet Gynaecol. 1986;93:100910. DOIPubMed
  6. Lee  GS, Kim  SJ, Park  IY, Shin  JC, Kim  SP. Tuberculous peritonitis in pregnancy. J Obstet Gynaecol Res. 2005;31:4368. DOIPubMed
  7. Sakorafas  GH, Ntavatzikos  A, Konstantiadou  I, Karamitopoulou  E, Kavatha  D, Peros  G. Peritoneal tuberculosis in pregnancy mimicking advanced ovarian cancer: a plea to avoid hasty, radical and irreversible surgical decisions. Int J Infect Dis. 2009;13:e2702. DOIPubMed
  8. Chow  KM, Chow  VC, Hung  LC, Wong  SM, Szeto  CC. Tuberculous peritonitis-associated mortality is high among patients waiting for the results of mycobacterial cultures of ascitic fluid samples. Clin Infect Dis. 2002;35:40913. DOIPubMed
  9. Hillebrand  DJ, Runyon  BA, Yasmineh  WG, Rynders  GP. Ascitic fluid adenosine deaminase insensitivity in detecting tuberculous peritonitis in the United States. Hepatology. 1996;24:140812. DOIPubMed
  10. Lighter-Fisher  J, Surette  AM. Performance of an interferon-gamma release assay to diagnose latent tuberculosis infection during pregnancy. Obstet Gynecol. 2012;119:108895. DOIPubMed

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Cite This Article

DOI: 10.3201/eid1903.121109

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Table of Contents – Volume 19, Number 3—March 2013

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Address for Correspondence: Kevin L. Ard, Brigham and Women’s Hospital; 75 Francis St, PBB-A4, Boston, MA 02115, USA

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Page created: February 12, 2013
Page updated: February 12, 2013
Page reviewed: February 12, 2013
The conclusions, findings, and opinions expressed by authors contributing to this journal do not necessarily reflect the official position of the U.S. Department of Health and Human Services, the Public Health Service, the Centers for Disease Control and Prevention, or the authors' affiliated institutions. Use of trade names is for identification only and does not imply endorsement by any of the groups named above.
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