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Volume 19, Number 3—March 2013
Dispatch

Prioritizing Tuberculosis Clusters by Genotype for Public Health Action, Washington, USA

Scott LindquistComments to Author , Sheanne Allen, Kim Field, Smita Ghosh, Maryam B. Haddad, Masahiro Narita, and Eyal Oren
Author affiliations: Author affiliations: Kitsap County Health District, Bremerton, Washington, USA (S. Lindquist); Washington State Department of Health, Olympia, Washington, USA (S. Lindquist, S. Allen, K. Field); Centers for Disease Control and Prevention, Atlanta, Georgia, USA (S. Ghosh, M.B. Haddad); Public Health–Seattle & King County Tuberculosis Control Program, Seattle, Washington, USA (M. Narita, E. Oren).

Main Article

Table

Comparison of geospatial analysis results and expert panel priority status rankings for county-level genotype clusters of TB cases, Washington, USA, 2005–2010*

County Spoliogtype 12-locus MIRU-VNTR Period 1†
 Period 2†
 Key epidemiologic features‡
No. cases LLR Expert priority No. cases LLR Expert priority
A 000000000003771 223321153643 32 31.8 High 19 18.3 High H, SA
000000000003771 223325173533 17 0.1 High 8 0.4 Low FB
677777477413771 254326223432 14 0.2 Low 14 0.1 Low FB
703377400001771 227425113434 4 1.2 Low 6 2.9 Low FB, H
000000000003771 223325153533 3 0.5 Low 1 <0.01 Low FB
000000000003771 223325163533 3 0.2 Low 7 1.7 Low FB, SA
677777477413771 254326223422 6 1.3 Low 4 0.4 Low FB
777000377760771 225125113322 3 0.6 Low 3 1.0 Low FB
000000000003771 222325173543 9 2.4 High 3 0.1 High H, SA
777777777760771 225125113322 3 0.7 Low 2 0.4 Low FB
000000000003771 222325173533 7 2.6 High 8 2.3 High
000000000003771 223325173433 3 1.5 Low 1 0.2 Low FB
000000000003771 223325133533 3 1.4 Low 0 <0.01 Low FB
000000000000000 223325123534 4 9.2 High 0 <0.01 Low H, SA
777776777620601
 224325153323
 3
 4.4
 High
0
 0.03
 Low
 H, SA
B
 000000000003771
 223425173563
 13
 19.5
 High
8
 13
 High
 H, SA
C 677777477413771 254326223432 6 1.3 Low 3 <0.01 Low FB, SA
777776777760771
 125325153225
 7
 9.8
 High
2
 1.8
 High
 H, SA
D 677777477413771 254326223432 5 0.8 Low 4 0.4 Low FB
777776757760771
 223325143324
 6
 8.7
 High
1
 1.2
 Low
E 677777477413771 254326223432 3 1.0 Low 2 0.9 Low FB

*LLRs >5.0 (boldface) indicate greater possibility that the cluster represents geographically concentrated TB cases, a proxy for recent TB transmission). TB, tuberculosis; MIRU-VNTR, mycobacterial interspersed repetitive unit–variable number tandem repeat; LLR, log-likelihood ratio, a measure of geospatial concentration; H, homelessness; FB, foreign born; SA, substance abuse.
†Period 1, January 1, 2005–December 31, 2007; period 2, January 1, 2008–December 31, 2010.
‡Blank cells indicate none present.

Main Article

Page created: February 01, 2013
Page updated: February 01, 2013
Page reviewed: February 01, 2013
The conclusions, findings, and opinions expressed by authors contributing to this journal do not necessarily reflect the official position of the U.S. Department of Health and Human Services, the Public Health Service, the Centers for Disease Control and Prevention, or the authors' affiliated institutions. Use of trade names is for identification only and does not imply endorsement by any of the groups named above.
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