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Volume 19, Number 5—May 2013

Research

World Health Organization International Standard to Harmonize Assays for Detection of Hepatitis E Virus RNA

Sally A. BaylisComments to Author , Johannes Blümel, Saeko Mizusawa, Keiji Matsubayashi, Hidekatsu Sakata, Yoshiaki Okada, C. Micha Nübling, Kay-Martin O. Hanschmann, and the HEV Collaborative Study Group
Author affiliations: Paul-Ehrlich-Institut, Langen, Germany (S.A. Baylis, J. Blümel, C.M. Nübling, K.-M.O. Hanschmann); National Institute of Infectious Diseases, Tokyo, Japan (S. Mizusawa, Y. Okada); Japanese Red Cross Hokkaido Block Blood Center, Sapporo, Japan (K. Matsubayashi, H. Sakata)

Main Article

Table 1

HEV strains diluted and lyophilized as candidate standards in study to establish a WHO International Standard for HEV RNA NAT-based assays*

Virus strain HEV RNA, copies/mL Genotype GenBank accession no. IgM/IgG against HEV Alanine aminotransferase, IU/L
HRC-HE104 1.6 × 107 3a AB630970 −/− 36
JRC-HE3 2.5 × 107 3b AB630971 +/− 398

*Strains were provided by the Japanese Red Cross Society Blood Service Headquarters, Tokyo, Japan. HEV, hepatitis E virus; WHO, World Health Organization; NAT, nucleic acid amplification technique.

Main Article

1Members of the HEV Collaborative Study Group are listed at the end of this article.

2In memory of Thomas Laue.

Page created: April 01, 2013
Page updated: April 01, 2013
Page reviewed: April 01, 2013
The conclusions, findings, and opinions expressed by authors contributing to this journal do not necessarily reflect the official position of the U.S. Department of Health and Human Services, the Public Health Service, the Centers for Disease Control and Prevention, or the authors' affiliated institutions. Use of trade names is for identification only and does not imply endorsement by any of the groups named above.
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