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Volume 19, Number 5—May 2013

World Health Organization International Standard to Harmonize Assays for Detection of Hepatitis E Virus RNA

Sally A. BaylisComments to Author , Johannes Blümel, Saeko Mizusawa, Keiji Matsubayashi, Hidekatsu Sakata, Yoshiaki Okada, C. Micha Nübling, Kay-Martin O. Hanschmann, and the HEV Collaborative Study Group
Author affiliations: Paul-Ehrlich-Institut, Langen, Germany (S.A. Baylis, J. Blümel, C.M. Nübling, K.-M.O. Hanschmann); National Institute of Infectious Diseases, Tokyo, Japan (S. Mizusawa, Y. Okada); Japanese Red Cross Hokkaido Block Blood Center, Sapporo, Japan (K. Matsubayashi, H. Sakata)

Main Article

Table 1

HEV strains diluted and lyophilized as candidate standards in study to establish a WHO International Standard for HEV RNA NAT-based assays*

Virus strain HEV RNA, copies/mL Genotype GenBank accession no. IgM/IgG against HEV Alanine aminotransferase, IU/L
HRC-HE104 1.6 × 107 3a AB630970 −/− 36
JRC-HE3 2.5 × 107 3b AB630971 +/− 398

*Strains were provided by the Japanese Red Cross Society Blood Service Headquarters, Tokyo, Japan. HEV, hepatitis E virus; WHO, World Health Organization; NAT, nucleic acid amplification technique.

Main Article

1Members of the HEV Collaborative Study Group are listed at the end of this article.

2In memory of Thomas Laue.

Page created: April 01, 2013
Page updated: April 01, 2013
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