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Volume 19, Number 5—May 2013
Letter

Azole-Resistant Aspergillus fumigatus, Iran

Seyedmojtaba SeyedmousaviComments to Author , Seyed Jamal Hashemi, Ensieh Zibafar, Jan Zoll, Mohammad T. Hedayati, Johan W. Mouton, Willem J.G. Melchers, and Paul E. Verweij
Author affiliations: Radboud University Nijmegen Medical Centre, Nijmegen, the Netherlands (S.Seyedmousavi, J.W Mouton, W.J.G.Melchers, P.E.Verweij); Nijmegen Institute for Infection, Inflammation and Immunity, Nijmegen (S.Seyedmousavi, J.W Mouton, W.J.G.Melchers, P.E.Verweij); Tehran University of Medical Sciences, Tehran, Iran (S.J.Hashemi, E.Zibafar); Mazndaran University of Medical Sciences, Sari, Iran (M.T.Hedayati)

Main Article

Table

Characteristics of 4 azole-resistant clinical Aspergillus fumigatus isolates, Iran*

Isolate Underlying disease Previous azole exposure 34-bp tandem repeat† Amino acid substitution in cyp51A gene‡
MIC, mg/L
Amphotericin B Itraconazole Voriconazole Posaconazole
T-IR-AF 12 CPA Yes Positive L98H 0.5 ≥16 4.0 0.5
T-IR-AF 17 CPA No Positive L98H 0.5 ≥16 4.0 0.5
T-IR-AF 433 CPA Yes Negative ND 0.5 ≥16 8.0 0.5
T-IR-AF 890 ABPA No Positive L98H 0.5 ≥16 8.0 0.25

*CPA, chronic pulmonary aspergillosis; ND, not detected; ABPA, allergic bronchopulmonary aspergillosis.
†34-bp tandem repeat in the promoter region of CYP51A gene.
‡The numbers indicate the position at which an amino acid change occurs. Nucleotides are numbered from the translation start codon ATG of cyp51A.

Main Article

Page created: April 23, 2013
Page updated: April 23, 2013
Page reviewed: April 23, 2013
The conclusions, findings, and opinions expressed by authors contributing to this journal do not necessarily reflect the official position of the U.S. Department of Health and Human Services, the Public Health Service, the Centers for Disease Control and Prevention, or the authors' affiliated institutions. Use of trade names is for identification only and does not imply endorsement by any of the groups named above.
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