Skip directly to site content Skip directly to page options Skip directly to A-Z link Skip directly to A-Z link Skip directly to A-Z link
Volume 19, Number 7—July 2013
Dispatch

Multidrug-Resistant Atypical Variants of Shigella flexneri in China

Shaofu Qiu1, Yong Wang1, Xuebin Xu1, Peng Li1, Rongzhang Hao1, Chaojie Yang1, Nan Liu1, Zhenjun Li1, Zhongqiang Wang1, Jian Wang1, Zhihao Wu1, Wenli Su1, Guang Yang1, Huiming Jin1, Ligui Wang1, Yansong Sun, Zhengan Yuan, Liuyu Huang, and Hongbin SongComments to Author 
Author affiliations: Academy of Military Medical Sciences, Beijing, China (S. Qiu, Y. Wang, P. Li, R. Hao, C. Yang, N. Liu, Z. Wang, J. Wang, Z. Wu, W. Su, G. Yang, L. Wang, Y. Sun, L. Huang, H. Song); Shanghai Municipal Center for Disease Control and Prevention, Shanghai, China (X. Xu, H. Jin, Z. Yuan); Chinese Center for Disease Control and Prevention, Beijing (Z. Li)

Main Article

Table 1

Distribution of different Shigella spp. in China during 2008–2010 and 1991–2000

Serotype 1991–2000*
 May 2008–December 2010
No. (%) isolates No. (%) isolates
S. flexneri 8,082 (86.2) 208 (76.2)
1a 272 (2.9) 9 (3.3)
1b 325 (3.5) 29 (10.6)
1c 15 (0.2) 0
2a 6,468 (69.0) 64 (23.4)
2b 152 (1.6) 3 (1.1)
3a 255 (2.7) 0
3b 57 (0.6) 0
3c 9 (0.1) 0
4 230 (2.5) 0
5 30 (0.3) 1 (0.4)
6 73 (0.8) 3 (1.1)
x 70 (0.7) 5 (1.8)
y 126 (1.3) 2 (0.7)
X variant (−:7,8, E1037), indole-negative variety
 0
73 (26.7)
S. flexneri serotype 2 variant (II:3,4,7,8)
 0
17 (6.2)
S. flexneri untypeable variant (−:E1037)
 0
2 (0.7)
S. sonnei
 1,022 (10.9)
56 (20.5)
S. dysenteriae
 132 (1.4)
6 (2.2)
S. boydii 139 (1.5) 3 (1.1)

*Data are from (1).

Main Article

References
  1. World Health Organization. Diarrhoeal disease; fact sheet no. 330, April 2013 [cited 2013 Apr 12]. http://www.who.int/mediacentre/factsheets/fs330/en/index.html
  2. World Health Organization. Guidelines for the control of shigellosis, including epidemics due to Shigella dysenteriae type 1 [cited 2013 Apr 12]. http://www.who.int/maternal_child_adolescent/documents/9241592330/en/index.html
  3. Wang  XY, Tao  F, Xiao  D, Lee  H, Deen  J, Gong  J, Trend and disease burden of bacillary dysentery in China (1991–2000). Bull World Health Organ. 2006;84:561–8. DOIPubMedGoogle Scholar
  4. Clinical and Laboratory Standards Institute. Performance standards for antimicrobial disk susceptibility tests; approved standard, 11th ed. CLSI document M02-A11. Wayne, PA: The Institute; 2012 [cited 2013 Apr 12]. http://antimicrobianos.com.ar/ATB/wp-content/uploads/2012/11/01-CLSI-M02-A11-2012.pdf
  5. EcMLST, a multilocus sequence typing database system for pathogenic E. coli. Version 1.2 [cited 2013 Apr 12]. http://www.shigatox.net/ecmlst/cgi-bin/index
  6. Ribot  EM, Fair  MA, Gautom  R, Cameron  DN, Hunter  SB, Swaminathan  B, Standardization of pulsed-field gel electrophoresis protocols for the subtyping of Escherichia coli O157:H7, Salmonella, and Shigella for PulseNet. Foodborne Pathog Dis. 2006;3:59–67. DOIPubMedGoogle Scholar
  7. Pryamukhina  NS, Khomenko  NA. Suggestion to supplement Shigella flexneri classification scheme with the subserovar Shigella flexneri 4c: phenotypic characteristics of strains. J Clin Microbiol. 1988;26:1147–9 .PubMedGoogle Scholar
  8. Ye  C, Lan  R, Xia  S, Zhang  J, Sun  Q, Zhang  S, Emergence of a new multidrug-resistant serotype X variant in an epidemic clone of Shigella flexneri. J Clin Microbiol. 2010;48:419–26 . DOIPubMedGoogle Scholar
  9. Qiu  S, Wang  Z, Chen  C, Liu  N, Jia  L, Liu  W, Emergence of a novel Shigella flexneri serotype 4s evolved from serotype X variant in China. J Clin Microbiol. 2011;49:1148–50. DOIPubMedGoogle Scholar
  10. Galanis  E, Lo Fo Wong  DM, Patrick  ME, Binsztein  N, Cieslik  A, Chalermchikit  T, Web-based surveillance and global Salmonella distribution, 2000–2002. Emerg Infect Dis. 2006;12:381–8. DOIPubMedGoogle Scholar
  11. Harris  AM, Chowdhury  F, Begum  YA, Khan  AI, Faruque  AS, Svennerholm  AM, Shifting prevalence of major diarrheal pathogens in patients seeking hospital care during floods in 1998, 2004, and 2007 in Dhaka, Bangladesh. Am J Trop Med Hyg. 2008;79:708–14 .PubMedGoogle Scholar
  12. Pazhani  GP, Niyogi  SK, Singh  AK, Sen  B, Taneja  N, Kundu  M, Molecular characterization of multidrug-resistant Shigella species isolated from epidemic and endemic cases of shigellosis in India. J Med Microbiol. 2008;57:856–63. DOIPubMedGoogle Scholar
  13. Bhattacharya  D, Purushottaman  SA, Bhattacharjee  H, Thamizhmani  R, Sudharama  SD, Manimunda  SP, Rapid emergence of third-generation cephalosporin resistance in Shigella sp. isolated in Andaman and Nicobar Islands, India. Microb Drug Resist. 2011;17:329–32. DOIPubMedGoogle Scholar
  14. von Seidlein  L, Kim  DR, Ali  M, Lee  H, Wang  X, Thiem  VD, A multicentre study of Shigella diarrhoea in six Asian countries: disease burden, clinical manifestations, and microbiology. PLoS Med. 2006;3:e353. DOIPubMedGoogle Scholar

Main Article

1These authors contributed equally to this article.

Page created: June 06, 2013
Page updated: June 06, 2013
Page reviewed: June 06, 2013
The conclusions, findings, and opinions expressed by authors contributing to this journal do not necessarily reflect the official position of the U.S. Department of Health and Human Services, the Public Health Service, the Centers for Disease Control and Prevention, or the authors' affiliated institutions. Use of trade names is for identification only and does not imply endorsement by any of the groups named above.
file_external