Volume 20, Number 10—October 2014
Dispatch
Treatment of Giardiasis after Nonresponse to Nitroimidazole
Eli Schwartz, Tamar Lachish, and Eli Schwartz
Table 2
Reports on management of giardiasis nonresponsive to nitroimidazole treatment worldwide, 1962–2013*
| Country and publication year | No. cases | No. patients who visited developing countries | No. cured/no. treated (% cured), by treatment type |
||||||
|---|---|---|---|---|---|---|---|---|---|
| Alb | Paromo | Nitaz | Alb + nitroimid | Quin | Quin + nitroimid | Paromo + nitroimid | |||
| Israel, 2014 (this study) | 12 | 10 | 3/9 (33.3) | 1/1 (100) | 1/4 (25.0) | 1/2 (50.0) | 2/2 (100) | – | – |
| Spain, 2014 | 3 | 3 | – | – | – | – | 3/3 (100.0) | – | – |
| Spain, 2013 | 14 | 14 | 0/2 | 0/4 | – | – | 14/14 (100) | – | – |
| Spain, 2010 | 10 | 8 | 0/2 | 0/3 | – | 1/1 (100) | – | 4/4 (100) | 2/2 (100) |
| Norway, 2008 | 38 | 0 | – | 3/6 (50.0) | – | 30/38 (78.9) | – | 3/3 (100) | – |
| United States, 2001 | 5 | 0 | 0/2 | 1/3 (33.3)† | – | – | – | 5/5 (100) | – |
| France, 2000 | 3 | 0 | 1/3 (33.3) | – | – | – | – | – | – |
| Italy, 1995 | 20 | 0 | 2/10 (20.0) | – | – | 9/10 (90.0) | – | – | – |
| Single case reports, 1962–2008‡ |
5 |
1 |
0/4 |
– |
1/1 (100) |
1/2 (50.0) |
0/2 |
2/2 (100) |
– |
| Total | 110 | 36 | 6/32 (18.7) | 5/17 (29.4) | 2/5 (40.0) | 42/53 (79.2)§ | 19/21 (90.5) | 14/14 (100) | 2/2 (100) |
*Complete reference information available in the online Technical Appendix (http://wwwnc.cdc.gov/EID/article/20/10/14-0073-Techapp1.pdf). Alb, albendazole; nitaz, nitazoxanide; nitroimid, nitroimidazole; paromo, paromomycin; quin, quinacrine; –, drug not used.
†Used in combination with bacitracin.
‡Single case reports from France, Switzerland, Canada, Saudi Arabia, and Thailand.
§p<0.001 by Fisher exact test for comparison with alb monotherapy.
Page created: September 22, 2014
Page updated: September 22, 2014
Page reviewed: September 22, 2014
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