Skip directly to site content Skip directly to page options Skip directly to A-Z link Skip directly to A-Z link Skip directly to A-Z link
Volume 20, Number 11—November 2014
Letter

Mycobacterium tuberculosis Beijing Genotype Resistance to Transient Rifampin Exposure

Alice L. den HertogComments to Author , Sandra Menting, Dick van Soolingen, and Richard M. Anthony
Author affiliations: KIT Biomedical Research, Royal Tropical Institute (KIT), Amsterdam, the Netherlands (A.L. den Hertog, S. Menting, R.M. Anthony); National Institute for Public Health and the Environment (RIVM), Bilthoven, the Netherlands (D. van Soolingen); Radboud University Medical Center, Nijmegen, the Netherlands (D. van Soolingen)

Main Article

Figure

Eight-day-old microcolonies (≈102 cells per colony) of a panel of Mycobacterium tuberculosis Beijing strains (A, B) and East African Indian strains and strain H37Ra (C, D). Growth of the strains was monitored after 4 hours of exposure to different concentrations of rifampin. For all colonies, the growth rate relative to preexposure growth rate was calculated at 0–1 days after exposure for a median of 889.5 (interquartile range 478.75–1611.25) colonies (left panels) and 1–5 days after exposure fo

Figure. Eight-day-old microcolonies (≈102 cells per colony) of a panel of Mycobacterium tuberculosis Beijing strains (A, B) and East African Indian strains and strain H37Ra (C, D). Growth of the strains was monitored after 4 hours of exposure to different concentrations of rifampin. For all colonies, the growth rate relative to preexposure growth rate was calculated at 0–1 days after exposure for a median of 889.5 (interquartile range 478.75–1611.25) colonies (left panels) and 1–5 days after exposure for a median of 363 (interquartile range 241.25–843.00) colonies (right panels) per strain and per condition. Plots are averages ±SD (indicated by error bars). The experimental conditions failed to totally inhibit growth of most Beijing colonies even at 5 days postexposure, whereas for the non-Beijing strains, virtually no growth was detectable at 5 days postexposure.

Main Article

Page created: October 20, 2014
Page updated: October 20, 2014
Page reviewed: October 20, 2014
The conclusions, findings, and opinions expressed by authors contributing to this journal do not necessarily reflect the official position of the U.S. Department of Health and Human Services, the Public Health Service, the Centers for Disease Control and Prevention, or the authors' affiliated institutions. Use of trade names is for identification only and does not imply endorsement by any of the groups named above.
file_external