Volume 20, Number 2—February 2014
Dispatch
Co-circulation of West Nile Virus Variants, Arizona, USA, 2010
Jessica A. Plante1, Kristen L. Burkhalter1, Brian R. Mann, Marvin S. Godsey, John-Paul Mutebi, and David W. C. Beasley
Table 2
Mouse virulence and antigenic characteristics of selected isolates of West Nile virus and NY99ic-derived E-312 variants, Arizona, USA, 2010*
| Strain/variant | Mouse neuroinvasiveness |
Neutralization indices ± SD |
|||
|---|---|---|---|---|---|
| ip LD50, PFU | AST ± SD (days) | 7H2 | 5H10 | α-EIII | |
| NY99ic | 0.3 | 8.7 ± 1.8 | 1.5 ± 0.2 | 1.5 ± 0.2 | 2.4 ± 0.3 |
| AZ10–75 | 0.5 | 8.7 ± 2.2 | 1.3 ± 0.5 | 1.3 ± 0.3 | 2.1 ± 0.3 |
| AZ10–581 | 0.8 | 9.8 ± 2.4 | 1.2 ± 0.2 | 1.3 ± 0.1 | 2.5 ± 0.2 |
| AZ10–91 | 0.5 | 7.8 ± 0.9 | ND | ND | ND |
| AZ10–892 | 0.3 | 8.6 ± 2.0 | ND | ND | ND |
| NY99–312F | 1.3 | 9.8 ± 1.9 | 1.5 ± 0.4 | 1.5 ± 0.4 | 2.5 ± 0.4 |
| NY99–312H | 0.8 | 8.5 ± 1.9 | 2.0 ± 0.1 | 1.7 ± 0.3 | 2.9 ± 0.0 |
| NY99–312I | 0.3 | 8.5 ± 1.4 | 1.8 ± 0.4 | 1.4 ± 0.3 | 2.5 ± 0.4 |
| NY99–312P | 630 | 13.0 ± 0.0 | 2.2 ± 0.1 | 2.0 ± 0.1 | 2.6 ± 0.2 |
| NY99–312R | 2.0 | 8.5 ± 2.2 | 1.8 ± 0.2 | 1.7 ± 0.1 | 2.7 ± 0.0 |
*Average survival time (AST) for each strain/variant was determined on the basis of animals in all dose groups that did not survive. Value significantly different (p<0.05 by Student t-test) from NY99ic is indicated in boldface. * ip, intraperitoneal; LD50, 50% lethal dose; ND, not determined.
1These authors contributed equally to this article.
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