Volume 20, Number 2—February 2014
Letter
NDM-1–producing Strains, Family Enterobacteriaceae, in Hospital, Beijing, China
Guang Zhou1, Si Guo1, Yanping Luo, Liyan Ye, Yang Song, Guangwei Sun, Ling Guo, Yong Chen, Li Han, and Jiyong Yang
Table
Phenotype and molecular characteristics of NDM-1–producing strains isolated from Chinese PLA General Hospital, Beijing, China, 2009–2013*
| Isolate no. | Organism | Source | ST† | Size, type of blaNDM-1 plasmid | Prevalence of RDs | MICs, mg/L |
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| CTX | FEP | TZP | IPM | MEM | ETP | AK | LVX | ||||||
| IR5028 | Escherichia coli | Urine | 167 | ≈190 kb, A/C | blaTEM, blaOXA-1,‡ blaCTX-group 1, 2, 9, aac(6′)-Ib-cr‡armA‡ | >256 | >256 | >256 | >32 | >32 | >32 | >256 | >32.0 |
| IR5047 | Klebsiella pneumoniae | Blood | 1,240 | ≈50 kb, X3 | blaTEM, blaSHV, blaOXA-1, qnrS,‡oqxAB‡ | >256 | 64 | >256 | 8 | 6 | >32 | 2 | 0.38 |
| IR5337 | Providencia rettgeri | Urine | NA‡ | ≈190 kb, A/C | blaPER, blaCMY, mtC‡ | >256 | >256 | >256 | >32 | >32 | 4 | >256 | >32.0 |
| IR5338 | Enterobacter cloacae | Urine | NA | ≈50 kb, X3 | blaSHV,‡ blaOXA-1,blaCTX-group 2 | >256 | >256 | >256 | >32 | >32 | >32 | 1.5 | 2.0 |
| IR5343 | Raoultella ornithinolytica | Abscess | NA | ≈70 kb, N | qnrS‡ | >256 | 32 | >256 | >32 | >32 | >32 | 2 | 0.75 |
*NDM-1, New Delhi metallo-β-lactamase-1–producing; ST, sequence type; RDs, resistance determinants; CTX, cefotaxime; FEP: cefepime; TZP, piperacillin-tazobactam; IMP, imipenem; MEM, meropenem; ETP, ertapenem; AK, amikacin; LVX, levofloxacin; NA, not applicable.
†The alleles at each of the multi-locus ST loci for a given isolate are combined into an allelic profile and assigned an ST designation.
‡Shown to be transferred by conjugation experiments.
1These authors contributed equally to this work.
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