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Volume 20, Number 4—April 2014
Research

Rapid Increase in Pertactin-deficient Bordetella pertussis Isolates, Australia

Connie Lam, Sophie Octavia, Lawrence Ricafort, Vitali Sintchenko, Gwendolyn L. Gilbert, Nicholas Wood, Peter McIntyre, Helen Marshall, Nicole Guiso, Anthony D. Keil, Andrew Lawrence, Jenny Robson, Geoff Hogg, and Ruiting LanComments to Author 
Author affiliations: University of New South Wales, Sydney, New South Wales, Australia (C. Lam. S. Octavia, L. Ricafort, R. Lan); University of Sydney, Sydney (V. Sintchenko, G.L. Gilbert); Westmead Hospital, Sydney, (V. Sintchenko, N. Wood, P. McIntyre); University of Adelaide, Adelaide, South Australia, Australia (H. Marshall); Institut Pasteur, Paris, France (N. Guiso); Princess Margaret Hospital for Children, Perth, Western Australia, Australia (A.D. Keil); Women’s and Children’s Hospital, Adelaide (A. Lawrence); Sullivan Nicolaides Pathology, Brisbane, Queensland, Australia (J. Robson); University of Melbourne, Parkville, Victoria, Australia (G. Hogg)

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Figure 1

Pertussis cases/100,000 population in Australia, 2008–20012, since mandatory reporting was instituted in 1991 and changes to pertussis vaccination schedule, including introduction of whole-cell vaccine (WCV) booster vaccinations for 4–5-year-old children in 1994–1995 and introduction of acellular vaccine (ACV) booster vaccinations in 1997. By 1999–2000, ACVs were used for all pertussis vaccinations. In 2003, the booster vaccinations for children 18 months of age was removed and replaced with a b

Figure 1. . . Pertussis cases/100,000 population in Australia, 2008–20012, since mandatory reporting was instituted in 1991 and changes to pertussis vaccination schedule, including introduction of whole-cell vaccine (WCV) booster vaccinations for 4–5-year-old children in 1994–1995 and introduction of acellular vaccine (ACV) booster vaccinations in 1997. By 1999–2000, ACVs were used for all pertussis vaccinations. In 2003, the booster vaccinations for children 18 months of age was removed and replaced with a booster vaccination for children 15–17 years of age (3).

Main Article

References
  1. Kurniawan  J, Maharjan  RP, Chan  WF, Reeves  PR, Sintchenko  V, Gilbert  GL, Bordetella pertussis clones identified by multilocus variable-number tandem-repeat analysis. Emerg Infect Dis. 2010;16:297300. DOIPubMed
  2. Quinn  HE, Mahajan  D, Hueston  L, Campbell  P, Menzies  RI, Gilbert  GL, The seroepidemiology of pertussis in NSW: fluctuating immunity profiles related to changes in vaccination schedules. N S W Public Health Bull. 2011;22:2249. DOIPubMed
  3. Campbell  P, McIntyre  P, Quinn  H, Hueston  L, Gilbert  GL, McVernon  J. Increased population prevalence of low pertussis toxin antibody levels in young children preceding a record pertussis epidemic in Australia. PLoS ONE. 2012;7:e35874. DOIPubMed
  4. Spokes  PJ, Quinn  HE, McAnulty  JM. Review of the 2008–2009 pertussis epidemic in NSW: notifications and hospitalisations. N S W Public Health Bull. 2010;21:16773. DOIPubMed
  5. Mooi  FR, van der Maas  NA, de Melker  HE. Pertussis resurgence: waning immunity and pathogen adaptation: two sides of the same coin. Epidemiol Infect. 2013;13:110. DOIPubMed
  6. Mooi  FR, van Loo  IH, van Gent  M, He  Q, Bart  MJ, Heuvelman  KJ, Bordetella pertussis strains with increased toxin production associated with pertussis resurgence. Emerg Infect Dis. 2009;15:120613. DOIPubMed
  7. Lam  C, Octavia  S, Bahrame  Z, Sintchenko  V, Gilbert  GL, Lan  R. Selection and emergence of pertussis toxin promoter ptxP3 allele in the evolution of Bordetella pertussis. Infect Genet Evol. 2012;12:4925. DOIPubMed
  8. Octavia  S, Maharjan  RP, Sintchenko  V, Stevenson  G, Reeves  PR, Gilbert  GL, Insight into evolution of Bordetella pertussis from comparative genomic analysis: evidence of vaccine-driven selection. Mol Biol Evol. 2011;28:70715. DOIPubMed
  9. Octavia  S, Sintchenko  V, Gilbert  GL, Lawrence  A, Keil  AD, Hogg  G, Newly emerging clones of Bordetella pertussis carrying prn2 and ptxP3 alleles implicated in Australian pertussis epidemic in 2008–2010. J Infect Dis. 2012;205:12204. DOIPubMed
  10. Hegerle  N, Paris  AS, Brun  D, Dore  G, Njamkepo  E, Guillot  S, Evolution of French Bordetella pertussis and Bordetella parapertussis isolates: increase of Bordetellae not expressing pertactin. Clin Microbiol Infect. 2012;•••:E3406 PubMed. DOIPubMed
  11. Bouchez  V, Brun  D, Cantinelli  T, Dore  G, Njamkepo  E, Guiso  N. First report and detailed characterization of B. pertussis isolates not expressing pertussis toxin or pertactin. Vaccine. 2009;27:603441. DOIPubMed
  12. Otsuka  N, Han  HJ, Toyoizumi-Ajisaka  H, Nakamura  Y, Arakawa  Y, Shibayama  K, Prevalence and genetic characterization of pertactin-deficient Bordetella pertussis in Japan. PLoS ONE. 2012;7:e31985. DOIPubMed
  13. Barkoff  AM, Mertsola  J, Guillot  S, Guiso  N, Berbers  G, He  Q. Appearance of Bordetella pertussis strains not expressing the vaccine antigen pertactin in Finland. Clin Vaccine Immunol. 2012;19:17034. DOIPubMed
  14. Weber  C, Boursaux-Eude  C, Coralie  G, Caro  V, Guiso  N. Polymorphism of Bordetella pertussis isolates circulating for the last 10 years in France, where a single effective whole-cell vaccine has been used for more than 30 years. J Clin Microbiol. 2001;39:4396403. DOIPubMed
  15. Mooi  FR, Hallander  H, Wirsing von Konig  CH, Hoet  B, Guiso  N. Epidemiological typing of Bordetella pertussis isolates: recommendations for a standard methodology. Eur J Clin Microbiol Infect Dis. 2000;19:17481. DOIPubMed
  16. Fry  NK, Neal  S, Harrison  TG, Miller  E, Matthews  R, George  RC. Genotypic variation in the Bordetella pertussis virulence factors pertactin and pertussis toxin in historical and recent clinical isolates in the United Kingdom. Infect Immun. 2001;69:55208. DOIPubMed
  17. Mooi  FR, van Oirschot  H, Heuvelman  K, van der Heide  HG, Gaastra  W, Willems  RJ. Polymorphism in the Bordetella pertussis virulence factors P.69/pertactin and pertussis toxin in the Netherlands: temporal trends and evidence for vaccine-driven evolution. Infect Immun. 1998;66:6705 .PubMed
  18. Boursaux-Eude  C, Thiberge  S, Carletti  G, Guiso  N. Intranasal murine model of Bordetella pertussis infection: II. Sequence variation and protection induced by a tricomponent acellular vaccine. Vaccine. 1999;17:265160. DOIPubMed
  19. Kinnear  SM, Boucher  PE, Stibitz  S, Carbonetti  NH. Analysis of BvgA activation of the pertactin gene promoter in Bordetella pertussis. J Bacteriol. 1999;181:523441 .PubMed
  20. Bodilis  H, Guiso  N. Virulence of pertactin-negative Bordetella pertussis isolates from infants, France. Emerg Infect Dis. 2013;19:4714 . DOIPubMed
  21. Queenan  AM, Cassiday  PK, Evangelista  A. Pertactin-negative variants of Bordetella pertussis in the United States. N Engl J Med. 2013;368:5834. DOIPubMed
  22. Pawloski  LC, Queenan  AM, Cassiday  PK, Lynch  AS, Harrison  M, Shang  W, Prevalence and molecular characterization of pertactin-deficient Bordetella pertussis in the US. Clin Vaccine Immunol. 2013. [Epub ahead of print].
  23. Schmidtke  AJ, Boney  KO, Martin  SW, Skoff  TH, Tondella  ML, Tatti  KM. Population diversity among Bordetella pertussis isolates, United States, 1935–2009. Emerg Infect Dis. 2012;18:124855. DOIPubMed
  24. Kurova  N, Njamkepo  E, Brun  D, Tseneva  G, Guiso  N. Monitoring of Bordetella isolates circulating in Saint Petersburg, Russia between 2001 and 2009. Res Microbiol. 2010;161:8105. DOIPubMed
  25. Njamkepo  E, Cantinelli  T, Guigon  G, Guiso  N. Genomic analysis and comparison of Bordetella pertussis isolates circulating in low and high vaccine coverage areas. Microbes Infect. 2008;10:15826. DOIPubMed
  26. Stibitz  S. IS481 and IS1002 of Bordetella pertussis create a 6-base-pair duplication upon insertion at a consensus target site. J Bacteriol. 1998;180:49636 .PubMed
  27. Parkhill  J, Sebaihia  M, Preston  A, Murphy  LD, Thomson  N, Harris  DE, Comparative analysis of the genome sequences of Bordetella pertussis, Bordetella parapertussis and Bordetella bronchiseptica. Nat Genet. 2003;35:3240. DOIPubMed
  28. Gogol  EB, Cummings  CA, Burns  RC, Relman  DA. Phase variation and microevolution at homopolymeric tracts in Bordetella pertussis. BMC Genomics. 2007;8:122. DOIPubMed
  29. Willems  R, Paul  A, van der Heide  HG, ter Avest  AR, Mooi  FR. Fimbrial phase variation in Bordetella pertussis: a novel mechanism for transcriptional regulation. EMBO J. 1990;9:28039 .PubMed
  30. Salaün  L, Snyder  LA, Saunders  NJ. Adaptation by phase variation in pathogenic bacteria. Adv Appl Microbiol. 2003;52:263301. DOIPubMed
  31. van Gent  M, van Loo  IH, Heuvelman  KJ, de Neeling  AJ, Teunis  P, Mooi  FR. Studies on prn variation in the mouse model and comparison with epidemiological data. PLoS ONE. 2011;6:e18014. DOIPubMed
  32. Bassinet  L, Gueirard  P, Maitre  B, Housset  B, Gounon  P, Guiso  N. Role of adhesins and toxins in invasion of human tracheal epithelial cells by Bordetella pertussis. Infect Immun. 2000;68:193441 . DOIPubMed

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Page updated: March 19, 2014
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