Volume 20, Number 5—May 2014
Bat Flight and Zoonotic Viruses
|Enhanced neutrophil and monocyte motility and emigration|
|Enhanced phagocytosis and pinocytosis|
|Increased oxygen radical production by phagocytes|
|Increased interferon production|
|Increased antiviral, antitumor, or antiproliferative, and natural killer cell stimulating activities of interferon|
|Potentiated interferon-induced anti-anaphylaxis (anergy)|
|Enhanced natural killer complement activation|
|Enhanced expression of Fc receptors|
|Increased T-helper cell activation, expression, recruitment, and cytotoxic activity|
|Blocked T-suppressor cell activity|
|Increased antibody production|
|Enhanced tumor necrosis factor-α|
|Increased T-cell proliferative response to nonspecific mitogens, interleukin-1 and −2, and allogeneic lymphocytes|
|Increased killing of intracellular bacteria|
|Increased bactericidal effect of antimicrobial agents|
|Induced cytoprotective heat-shock proteins in host cells|
|Induced pathogen heat-shock proteins, which activate host defenses|
|Induced cytoprotective heat-shock proteins in host cells|
- Calisher CH, Childs JE, Field HE, Holmes KV, Schountz T. Bats: important reservoir hosts of emerging viruses. Clin Microbiol Rev. 2006;19:531–45 .
- Dobson AP. What links bats to emerging infectious diseases? Science. 2005;310:628–9.
- Ge XY, Li JL, Yang XL, Chmura AA, Zhu G, Epstein JH, Isolation and characterization of a bat SARS-like coronavirus that uses the ACE2 receptor. Nature. 2013;503:535–8.
- Leroy EM, Kumulungui B, Pourrut X, Rouquet P, Hassanin A, Yaba P, Fruit bats as reservoirs of Ebola virus. Nature. 2005;438:575–6.
- Towner JS, Amman BR, Sealy TK, Carroll SA, Comer JA, Kemp A, Isolation of genetically diverse Marburg viruses from Egyptian fruit bats. PLoS Pathog. 2009;5:e1000536.
- Halpin K, Young PL, Field HE, Mackenzie JS. Isolation of Hendra virus from pteropid bats: a natural reservoir of Hendra virus. J Gen Virol. 2000;81:1927–32 .
- Chua KB, Koh CL, Hooi PS, Wee KF, Khong JH, Chua BH, Isolation of Nipah virus from Malaysian Island flying foxes. Microbes Infect. 2002;4:145–51.
- Baker ML, Schountz T, Wang LF. Antiviral immune responses of bats: a review. Zoonoses Public Health. 2013;60:104–16.
- Sohayati AR, Hassan L, Sharifah SH, Lazarus K, Zaini CM, Epstein JH, Evidence for Nipah virus recrudescence and serological patterns of captive Pteropus vampyrus. Epidemiol Infect. 2011;139:1570–9.
- Zhang G, Cowled C, Shi Z, Huang Z, Bishop-Lilly KA, Fang X, Comparative analysis of bat genomes provides insight into the evolution of flight and immunity. Science. 2013;339:456–60.
- Blatteis CM. Fever: pathological or physiological, injurious or beneficial? J Therm Biol. 2003;28:1–13.
- Hasday JD, Fairchild KD, Shanholtz C. The role of fever in the infected host. Microbes Infect. 2000;2:1891–904.
- Speakman JR, Thomas DW. Physiological ecology and energetics of bats. In: Kunz TH, Fenton MB, editors. Bat ecology. Chicago: University of Chicago Press; 2003. p. 430–90.
- Thomas SP, Suthers RA. The physiology and energetics of bat flight. J Exp Biol. 1972;57:317–35.
- Bundle MW, Hansen KS, Dial KP. Does the metabolic rate–flight speed relationship vary among geometrically similar birds of different mass? J Exp Biol. 2007;210:1075–83.
- Książek A, Konarzewski M. Effect of dietary restriction on immune response of laboratory mice divergently selected for basal metabolic rate. Physiol Biochem Zool. 2012;85:51–61.
- Cutrera AP, Zenuto RR, Luna F, Antenucci CD. Mounting a specific immune response increases energy expenditure of the subterranean rodent Ctenomys talarum (tuco-tuco): implications for intraspecific and interspecific variation in immunological traits. J Exp Biol. 2010;213:715–24.
- Martin LB, Weil ZM, Nelson RJ. Seasonal changes in vertebrate immune activity: mediation by physiological trade-offs. Philos Trans R Soc Lond B Biol Sci. 2008;363:321–39.
- Canale CI, Henry PY. Energetic costs of the immune response and torpor use in a primate. Funct Ecol. 2011;25:557–65.
- Carpenter RE. Flight physiology of intermediate-sized fruit bats (Pteropodidae). J Exp Biol. 1986;120:79–103.
- Burbank RC, Young JZ. Temperature changes and winter sleep of bats. J Physiol. 1934;82:459–67 .
- Morrison P. Body temperatures in some Australian mammals. I. Chiroptera. Biol Bull. 1959;116:484–97.
- Voigt CC, Lewanzik D. Trapped in the darkness of the night: thermal and energetic constraints of daylight flight in bats. Proc Biol Sci. 2011;278:2311–7.
- Morrison P, McNab BK. Temperature regulation in some Brazilian phyllostomid bats. Comp Biochem Physiol. 1967;21:207–21.
- Roverud RC, Chappell MA. Energetic and thermoregulatory aspects of clustering behavior in the neotropical bat Noctilio albiventris. Physiol Zool. 1991;64:1527–41.
- Reeder WG, Cowles RB. Aspects of thermoregulation in bats. J Mammal. 1951;32:389–403.
- Willis CKR, Brigham RM. Defining torpor in free-ranging bats: experimental evaluation of external temperature-sensitive radiotransmitters and the concept of active temperature. J Comp Physiol B. 2003;173:379–89.
- Bronner GN, Maloney SK, Buffenstein R. Survival tactics within thermally-challenging roosts: heat tolerance and cold sensitivity in the Angolan free-tailed bat, Mops condylurus. S Afr J Zool. 1999;34:1–10.
- Herreid CF II. Temperature regulation and metabolism in Mexican freetail bats. Science. 1963;142:1573–4.
- Leitner P. Body temperature, oxygen consumption, heart rate and shivering in the California mastiff bat, Eumops perotis. Comp Biochem Physiol. 1966;19:431–43.
- O’Farrell MJ, Bradley WG. Comparative thermal relationships of flight for some bats in southwestern United States. Comp Biochem Physiol A. 1977;58:223–7.
- Thomas DW. The physiological ecology of hibernation in vespertilionid bats. In: Racey PA, Swift, SM, editors. Ecology, evolution, and behaviour of bats. Oxford (UK): Clarendon Press; 1995. p. 233–44.
- Long GH, Boots M. How can immunopathology shape the evolution of parasite virulence? Trends Parasitol. 2011;27:300–5.
- Meteyer CU, Barber D, Mandl JN. Pathology in euthermic bats with white nose syndrome suggests a natural manifestation of immune reconstitution inflammatory syndrome. Virulence. 2012;3:583–8.
- Graham AL, Allen JE, Read AF. Evolutionary causes and consequences of immunopathology. Annu Rev Ecol Evol Syst. 2005;36:373–97.
- Clark DW Jr. Bats and environmental contaminants: a review. US Fish and Wildlife Service Special Scientific Report—Wildlife 1981; 235:1–27.
- LeGrand EK, Alcock J. Turning up the heat: immune brinksmanship in the acute-phase response. Q Rev Biol. 2012;87:3–18.
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