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Volume 20, Number 6—June 2014
CME ACTIVITY - Synopsis

Adverse Pregnancy Outcomes and Coxiella burnetii Antibodies in Pregnant Women, Denmark

Stine Yde NielsenComments to Author , Kåre Mølbak, Tine Brink Henriksen, Karen Angeliki Krogfelt, Carsten Schade Larsen, and Steen Villumsen
Author affiliations: Aarhus University Hospital, Aarhus, Denmark (S.Y. Nielsen, T.B. Henriksen, C.S. Larsen); Statens Serum Institut, Copenhagen, Denmark (K. Mølbak, K.A. Krogfelt, S. Villumsen)

Main Article

Table 2

Results of testing for 12 women who had positive Coxiella burnetii titers during pregnancy, Denmark*

Pt and preg First sample
 Last sample
 Comments
Date collected† Titers
 Date collected† Titers
IgM II IgM I IgG II IgG I IgM II IgM I IgG II IgG I
Pt 1
 7 wk
 2,048
 8,000
 1,024
 512
38 wk
 <64
 <64
 256
 <128
 Negative titers 6 mo before this preg
Pt 2
 8 wk, after miscarriage
 256
 <64
 256
 128
7 wk, after extrauterine preg
 512
 128
 512
 512
 Maximum titers after second miscarriage: IgG phase II, 4,096; IgG phase I, 2,048; IgM phase I, 512; IgM phase II, 256
Pt 3
 3 wk
 <64
 <64
 <128
 512
33
 <64
 <64
 128
 1,024
 First titers taken 2 mo before this preg: IgG phase I, 1,024. Maximum titers in preg week 9: IgG phase I, 4,096; IgG phase II, 256‡
Pt 4
 10 wk
 <64
 <64
 1,024
 512
1 day postpartum
 <64
 <64
 1,024
 128
 First titers taken 3 mo before this preg identical to titers from preg week 10§
Pt 5
Preg 1 9 wk <64 <64 256 512 38 wk <64 <64 256 256 First titers taken 6 mo before this preg: IgM phase II, <64; IgM phase I, <64; IgG phase II, 512; IgG phase I, 1,024§
Preg 2
 12 wk
 <64
 <64
 128
 1,024
31 wk
 <64
 <64
 512
 1,024
 §
Pt 6
 13 wk
 <64
 <64
 256
 <128
At birth
 <64
 <64
 128
 <128
 No titers available before this preg. Maximum titers in preg: IgG phase II, 256‡
Pt 7
 8 wk
 128
 <64
 4,096
 <128
At birth
 64
 <64
 512
 <128
 Titers positive 6 mo before this preg: IgM phase II, 128; IgM phase I, <64; IgG phase II, 2048; IgG phase I, <128§
Pt 8
Preg 1 12 wk 128 <64 512 256 26 wk 256 <64 1,024 256 Maximum titers in this preg: IgG phase II, 2,048‡
Preg 2
 10 wk
 <64
 <64
 256
 128
26 wk
 <64
 <64
 256
 256
 Maximum titers in this preg: IgG phase I, 1,024; IgG phase II, 1,024‡
Pt 9
Preg 1 10 wk <64 <64 256 <128 39 wk 64 <64 128 <128 Maximum titers in this preg: phase II IgG, 1,024‡
Preg 2
 12 wk
 <64
 <64
 256
 <128
36 wk
 <64
 <64
 256
 <128
 §
Pt 10
Preg 1 8 wk 512 <64 4,096 <128 36 wk <64 <164 256 <128 No titers available before this preg§
Preg 2
 9 wk
 <64
 <64
 128
 <128
14 wk
 <64
 <64
 <128
 <128
 §
Pt 11
 7 wk
 <64
 <64
 128
 128
26 wk
 256
 256
 512
 <128
 Titers positive 1 mo before this preg: IgM phase II, <64; IgM phase I, <64; IgG phase II, 1,024; IgG phase I, <128§
Pt 12 10 wk <64 <64 2,048 <128 37 wk <64 <64 1,024 1,024 Negative titers during preg 2 years earlier. Maximum titers in this preg: IgG phase II, 2,048

*See Table 1 for specific patient and outcome data. Pt, patient; preg, pregnancy; vet, veterinarian; NA, not applicable; IUGR, intrauterine growth restriction.
†Gestational week.
‡Remaining titers have not risen above/beyond values in beginning/end of pregnancy.
§No further rise of titers in this pregnancy; indicates that titers had not risen beyond values at beginning/end of pregnancy.

Main Article

Page created: May 14, 2014
Page updated: May 14, 2014
Page reviewed: May 14, 2014
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