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Volume 20, Number 7—July 2014
Research

Changes in Capsule and Drug Resistance of Pneumococci after Introduction of PCV7, Japan, 2010–2013

Naoko Chiba, Miyuki Morozumi, Michi Shouji, Takeaki Wajima, Satoshi Iwata, Kimiko UbukataComments to Author , and the Invasive Pneumococcal Diseases Surveillance Study Group
Author affiliations: Keio University School of Medicine, Tokyo, Japan (N. Chiba, M. Morozumi, S. Iwata, K. Ubukata); Kitasato University, Tokyo (N. Chiba, M. Morozumi, K. Ubukata); National Cancer Center Hospital, Tokyo (M. Shouji); Tokyo University of Pharmacy and Life Sciences, Tokyo (T. Wajima)

Main Article

Table 1

Vaccine and nonvaccine serotypes of Streptococcus pneumoniae in children after introduction of PCV7, Japan, April 2010–March 2013*

Age group, y, and serotype Isolates, no. (%)
p value
2010, 
n = 300† 2011, 
n = 146‡ 2012, 
n = 156§
<1 <0.001
VT 51 (17.0)‡ 26 (17.8) 3 (1.9)
  NVT
19 (6.3)
14 (9.6)
25 (16.0)

1 <0.001
  VT 103 (34.3) 25 (17.1) 9 (5.8)
  NVT
31 (10.3)
28 (19.2)
62 (39.7)

2–4 <0.001
  VT 55 (18.3) 23 (15.8) 6 (3.8)
  NVT
19 (6.3)
14 (9.6)
39 (25.0)

>5 0.733
  VT 11 (3.7) 6 (4.1) 5 (3.2)
  NVT
11 (3.7)
10 (6.8)
7 (4.5)

Total <0.001
  VT 220 (73.3) 80 (54.8) 23 (14.7)
  NVT 80 (26.7) 66 (45.2) 133 (85.3)

*PCV7, 7-valent pneumococcal conjugate vaccine; VT, vaccine serotype (serotypes 4, 6B, 9V, 14, 18C, 19F, 23F); NVT, serotypes not included in PCV7.
†Voluntary vaccination with PCV7.
‡Implementation of Urgent Promotion of Vaccination incentive.
§Just before the introduction of 13-valent PCV.

Main Article

Page created: June 17, 2014
Page updated: June 17, 2014
Page reviewed: June 17, 2014
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