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Volume 20, Number 7—July 2014
Research

Population-Based Analysis of Invasive Fungal Infections, France, 2001–2010

Dounia Bitar1, Olivier Lortholary1, Yann Le Strat, Javier Nicolau, Bruno Coignard, Pierre Tattevin, Didier Che2Comments to Author , and Françoise Dromer2
Author affiliations: Insitut de Veille Sanitaire, Saint Maurice, France (D. Bitar, Y. Le Strat, J. Nicolau, B. Coignard, D. Che); Institut Pasteur, Paris, France (O. Lortholary, F. Dromer); Centre National de la Recherche Scientifique, Paris (O. Lortholary, F. Dromer); Université Paris Descartes, Paris (O. Lortholary); CHUPontchaillou, Rennes, France (P. Tattevin)

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Figure 2

A) Invasive fungal infections in patients with hematologic malignancies (HM) in France, 2004–2010. The case count continuously increased (p<0.001) over the period. Candidemia increased from 751.4 to 1,028.2 cases (+4.3%, p = 0.001), invasive aspergillosis (IA) from 2,112.4 to 2,434.2 cases (+2.7%, p = 0.002), and mucormycosis from 73.0 to 105.8 cases (+8.7%, p = 0.05) per 100,000 patients per year. Inversely, the incidence of Pneumocystis jirovecii pneumonia (Pjp) decreased from 468.0 to 351.

Figure 2. A) Invasive fungal infections in patients with hematologic malignancies (HM) in France, 2004–2010The case count continuously increased (p<0.001) over the periodCandidemia increased from 751.4 to 1,028.2 cases (+4.3%, p = 0.001), invasive aspergillosis (IA) from 2,112.4 to 2,434.2 cases (+2.7%, p = 0.002), and mucormycosis from 73.0 to 105.8 cases (+8.7%, p = 0.05) per 100,000 patients per yearInversely, the incidence of Pneumocystis jirovecii pneumonia (Pjp) decreased from 468.0 to 351.5 cases/100,000 patients/year (−4.4%, p = 0.006)B) In HSCT recipients (average 4,300 cases per year, no significant trend), candidemia increased from 721.5 to 1008.6 cases (+6.0%, p = 0.05) and invasive aspergillosis from 2,573.4 to 3,705.3 cases (+9.8%, p<0.001) per 100,000 HM patients per yearC) The number of patients with solid tumors continuously increased (p<0.001), and candidemia increased among those patients from 33.7 to 40.9 cases/100,000 patients/year (+6.2%, p<0.001)D) The number of patients with chronic renal failure continuously increased (p<0.001)Candidemia increased from 57.9 to 88.6 cases/100,000 patients/year (+8.1%), IA from 7.0 to 12.0 cases/100,000 patients/year (+18.4%, p = 0.007), and Pjp increased with a peak during 2007–2008 (+11.1%, p = 0.052)E) In the HIV/AIDS population (increase p<0.001), incidence of Pjp and cryptococcosis decreased by −17.9% and −19.0%, respectively (p<0.001)HSCT, hematologic stem cell transplant.

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1These authors contributed equally to this article.

2These authors contributed equally to this article.

Page created: June 17, 2014
Page updated: June 17, 2014
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