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Volume 21, Number 1—January 2015
Research

Neurotropic Threat Characterization of Burkholderia pseudomallei Strains

Jodie L. MorrisComments to Author , Anne Fane, Catherine M. Rush, Brenda L. Govan, Mark Mayo, Bart J. Currie, and Natkunam Ketheesan
Author affiliations: James Cook University, Townsville, Queensland, Australia (J. Morris, A. Fane, C. Rush, B. Govan, N. Ketheesan); Menzies School of Health Research, Darwin, Northern Territory, Australia (M. Mayo, B.J. Currie); Royal Darwin Hospital, Darwin (B.J. Currie)

Main Article

Table 1

Clinical features of Burkholderia pseudomallei strains isolated from patients with neurologic and nonneurologic melioidosis and their virulence in C57BL/6 and BALB/c mice, Northern Territory, Australia, October 1989–October 2012*

MSHR ID no. Age, y/sex Clinical feature Risk factor ID50 in mice (CFU)†
Intranasal
 Subcutaneous
C57BL/6 BALB/c C57BL/6 BALB/c
Neurologic
668‡ 53/M Severe neurologic signs None 4.1 × 104 2.9 × 102 7.1 × 103 <10
305§ 64/M Severe neurologic signs Alcohol use 2.6 × 102 2.6 × 102 3.7 × 104 <10
62‡ 24/M Severe neurologic signs None 2.2 × 102 6.3 × 101 2.4 × 102 <10
435‡ 37/M Severe neurologic signs Kava 5.0 × 102 1.3 × 102 <10 <10
1153§ 60/M Severe neurologic signs Diabetes mellitus 1.7 <10 <10 <10
3709‡
 14/M
 Moderate neurologic signs
 None
 4.4 × 104
 1.8 × 104
2.2 × 102
 1.3 × 102
Nonneurologic
1655‡ 61/F Chronic pulmonary Bronchiectasis >108 >108 >2 × 108 >2 × 108
465§ 67/M Septicemia Diabetes mellitus, chronic obstructive pulmonary disease 1.3 × 105 1.1 × 103 8.3 × 105 <10
2138‡ 49/F Septicemia Diabetes mellitus 3.6 × 103 <10 4.2 × 103 1.2 × 101
346‡ 49/M Chronic pulmonary Alcohol use 8.5 × 104 6.0 × 104 6.0 × 105 7.0 × 105
543‡ 22/F Skin ulcer None 2.9 × 102 8.5 × 101 1.2 × 101 <10

*ID50, 50% infectious dose; MSHR ID, neurologic isolate identification.
†ID50 determined after intranasal and subcutaneous infection of C57BL/6 and BALB/c mice
‡Nonfatal.
§Fatal.

Main Article

Page created: December 17, 2014
Page updated: December 17, 2014
Page reviewed: December 17, 2014
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