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Volume 21, Number 1—January 2015

Dispatch

Oseltamivir-Resistant Influenza A(H1N1)pdm09 Viruses, United States, 2013–14

Margaret Okomo-Adhiambo, Alicia Fry, Su Su, Ha T. Nguyen, Anwar Abd Elal, Elizabeth Negron, Julie Hand, Rebecca J. Garten, John Barnes, Xu Xiyan, Julie M. Villanueva, Larisa GubarevaComments to Author , and 2013–14 US Influenza Antiviral Working Group
Author affiliations: Centers for Disease Control and Prevention, Atlanta, Georgia, USA (M. Okomo-Adhiambo, A.M. Fry, S. Su, H.T. Nguyen, A.A Elal, R.J. Garten, J. Barnes, X. Xiyan, J.M Villanueva, L.V. Gubareva); Atlanta Research and Education Foundation, Atlanta (S. Su); Battelle Memorial Institute, Atlanta (H.T. Nguyen, A.A. Elal); Pennsylvania Department of Health, Harrisburg, Pennsylvania, USA (E. Negron); Louisiana Office of Public Health, New Orleans, Louisiana, USA (J. Hand)

Main Article

Figure 2

Evolutionary relationships among influenza A (H1N1)pdm09 virus neuraminidase genes, United States, 2013–14. Phylogenetic tree was generated by using the MEGA software package v5.2 (http://www.megasoftware.net/) and the neighbor-joining method. Evolutionary distances were computed by using the maximum composite likelihood model. Analysis included 100 representative A(H1N1)pdm09 neuraminidase gene sequences. Scale bar indicates nucleotide substitutions per site. Solid circles indicate oseltamivir-

Figure 2. Evolutionary relationships among influenza A (H1N1)pdm09 virus neuraminidase genes, United States, 2013–14. Phylogenetic tree was generated by using MEGA software v5.2 (http://www.megasoftware.net/) and the neighbor-joining method. Evolutionary distances were computed by using the maximum composite likelihood model. Analysis included 100 representative A(H1N1)pdm09 neuraminidase gene sequences. Scale bar indicates nucleotide substitutions per site. Solid circles indicate oseltamivir-resistant H275Y markers. A/California/07/2009 (current Northern Hemisphere vaccine strain) virus was used as a reference for ancestry (root) and numbering. F, Centers for Disease Control and Prevention reference antigen; Oct, October 2013; Nov, November 2013; Dec, December 2013; Jan, January 2014; Feb, February 2014; GLY, glycosylation.

Main Article

1Members of the 2013–14 US Antiviral Working Group are listed at the end of this article.

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