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Volume 21, Number 11—November 2015
CME ACTIVITY - Synopsis

Neurologic Disorders in Immunocompetent Patients with Autochthonous Acute Hepatitis E

H. Blasco Perrin, P. Cintas, F. Abravanel, R. Gérolami, L. d'Alteroche, J.-N. Raynal, L. Alric, E. Dupuis, L. Prudhomme, E. Vaucher, P. Couzigou, J.-M. Liversain, C. Bureau, J.-P. Vinel, N. Kamar, J. Izopet, and J.-M. Peron
Author affiliations: Hôpital Purpan–CHU Toulouse, Toulouse, France (H. Blasco Perrin, P. Cintas, F. Abravanel, L. Alric, C. Bureau, J.-P. Vinel, J. Izopet, J.M. Peron); Hôpital de La Conception–CHU Marseille, Marseille, France (R. Gérolami); Hôpital Trousseau–CHU Tours, Tours, France (L. d'Alteroche); Clinique de l’Union, l’Union, France (J.-N. Raynal); Clinique Pasteur, Toulouse (E. Dupuis); CHIC Castres-Mazamet, Castres-Mazamet, France (L. Prudhomme); CH Narbonne, Narbonne, France (E. Vaucher); Hôpital du Haut-Lévêque–CHU Bordeaux, Bordeaux, France (P. Couzigou); CH Mont de Marsan, Mont de Marsan, France (J.-M. Liversain); Hôpital Ranguei–CHU Toulouse, Toulouse (L. Buscail, N. Kamar)

Main Article

Table 2

Liver test results and virologic characteristics of 15 patients with hepatitis E virus–linked neurologic disorders, France, January 2006–June 2013*

Patient no. Diagnosis AST, IU/L ALT, IU/L Bilirubin, µmol/L ALKP, IU/L GGT, IU/L PT, % GT Serology Serum viral load, log-copies/mL PCR stools PCR CSF
1 MM 69 256 8.6 254 323 92 3f IgG+/IgM+ 4.92 NA NA
2 MM 507 756 17 540 187 90 3f IgG+/IgM+ 5 Pos NA
3 MM NA 3,641 90 NA NA 80 NA IgG+/IgM+ Neg Neg NA
4 MM 54 120 10 NA 95 100 NA IgG+/IgM+ Neg Neg NA
5 MM 50 118 14 90 95 95 NA IgG+/IgM+ Pos NA Neg
6 MM 71 119 14 430 131 100 3f IgG–/IgM+ 5.57 Pos NA
7 PTS 897 1,834 42 336 383 88 NA IgG+/IgM+ 2.12 NA NA
8 PTS 1.330 1,900 15 194 182 95 NA IgG+/IgM+ 2.81 NA NA
9 PTS 601 1,376 15 231 601 95 NA IgG+/IgM+ NA NA NA
10 PTS 135 495 17 659 740 100 3f IgG+/IgM+ 3.89 Pos NA
11 MR 1.742 822 101 704 528 76 3f IgG+/IgM+ 5.83 Pos Pos
12 MR 221 566 11 124 184 100 NA IgG+/IgM+ Pos NA Pos
13 MR 100 246 4.7 248 33 98 3f IgG–/IgM+ 2.9 Pos Neg
14 AIDP 113 384 34.2 474 783 100 3f IgG+/IgM+ Pos Pos Neg
15 AIDP 37 49 7 88 48 94 NA IgG+/IgM+ Neg Neg Neg

*AST, aspartate aminotransferase; ALT, alanine aminotransferase; ALKP, alkaline phosphatase; GGT, γ-glutamyl transpeptidase; PT, prothrombin time; GT, genotype; CSF, cerebral spinal fluid; MM: mononeuritis multiplex, NA, not available; Pos, positive; Neg, negative; PTS: Parsonage-Turner syndrome; MR: meningoradiculitis; AIDP, acute inflammatory demyelinating polyradiculoneuropathy.

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Page created: October 19, 2015
Page updated: October 19, 2015
Page reviewed: October 19, 2015
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