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Volume 21, Number 11—November 2015
Research

Association of Higher MERS-CoV Virus Load with Severe Disease and Death, Saudi Arabia, 2014

Daniel R. Feikin, Basem M. Alraddadi, Mohammed Qutub, Omaima Shabouni, Aaron Curns, Ikwo K. Oboho, Sara M. Tomczyk, Bernard J. Wolff, John T. Watson, and Tariq A. MadaniComments to Author 
Author affiliations: Centers for Disease Control and Prevention, Atlanta, Georgia, USA (D.R. Feikin, A. Curns, I.K. Oboho, S.M. Tomczyk, B. Wolff, J.T. Watson); Ministry of Health, Jeddah, Saudi Arabia (B. Al-Raddadi, M. Qutub, O. Shabouni, T.A. Madani); King Faisal Specialist Hospital and Research Center, Jeddah (B. Al-Raddadi, M. Qutub); King Abdulaziz University, Jeddah (T.A. Madani)

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Figure 2

Box plot of Ct values for 102 patients infected with MERS-CoV by severity status. Kingdom of Saudi Arabia, 2014. A) Patients who were alive (n = 61) versus dead (n = 41) at the time of follow-up chart review or phone contact. Wilcoxon rank-sum test, p = 0.0087. B) Patients who had a severe outcome (death or ICU admission, n = 48) versus nonsevere outcome (n = 54). Wilcoxon rank-sum test, p = 0.0036. C) Patients who were admitted to the ICU (n = 36) versus the regular ward (n = 31). Wilcoxon rank

Figure 2. Box plot of Ct values for 102 patients infected with MERS-CoV by severity status. Kingdom of Saudi Arabia, 2014. A) Patients who were alive (n = 61) versus dead (n = 41) at the time of follow-up chart review or phone contact. Wilcoxon rank-sum test, p = 0.0087. B) Patients who had a severe outcome (death or ICU admission, n = 48) versus nonsevere outcome (n = 54). Wilcoxon rank-sum test, p = 0.0036. C) Patients who were admitted to the ICU (n = 36) versus the regular ward (n = 31). Wilcoxon rank-sum test, p = 0.014. D) Among patients who survived, symptomatic (n = 30) versus mildly symptomatic/asymptomatic (n = 31). Wilcoxon rank-sum test, p = 0.08. Box and whiskers plot features are as follows: central line in box is median, bottom line of box is first quartile (25%), top line of box is third quartile (75%), diamond is mean, bottom of whiskers is first quarter minus 1.5 × interquartile range, top of whiskers is third quarter plus 1.5 × interquartile range, and dots are outliers. Ct , cycle threshold; ICU, intensive care unit; MERS-CoV, Middle East respiratory syndrome coronavirus.

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Page created: October 16, 2015
Page updated: October 16, 2015
Page reviewed: October 16, 2015
The conclusions, findings, and opinions expressed by authors contributing to this journal do not necessarily reflect the official position of the U.S. Department of Health and Human Services, the Public Health Service, the Centers for Disease Control and Prevention, or the authors' affiliated institutions. Use of trade names is for identification only and does not imply endorsement by any of the groups named above.
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