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Volume 21, Number 11—November 2015
Dispatch

Epidemiology of Primary Multidrug-Resistant Tuberculosis, Vladimir Region, Russia

Julia ErshovaComments to Author , Grigory V. Volchenkov, Dorothy A. Kaminski, Tatiana R. Somova, Tatiana A. Kuznetsova, Natalia V. Kaunetis, J. Peter Cegielski, and Ekaterina V. Kurbatova
Author affiliations: Centers for Disease Control and Prevention, Atlanta, Georgia, USA (J.V. Ershova, D.A. Kaminski, J.P. Cegielski, E.V. Kurbatova); Vladimir Oblast TB Dispensary, Vladimir, Russia (G.V. Volchenkov, T.R. Somova, T.A. Kuznetsova, N.V. Kaunetis)

Main Article

Table

Association between sociodemographic and clinical characteristics of persons with newly diagnosed cases of non–MDR TB and MDR TB, Vladimir Region, Russia, 2012*

Characteristic Total, n = 191 MDR TB, n = 44 Non–MDR TB, n = 147 Prevalence ratio 95% CI p value
Sex
Male 146 (74.4) 34 (77.3) 112 (76.2) 1.05 0.56–1.95 0.88
Female
45 (23.6)
10 (22.7)
35 (23.8)
Referent


Median age, y (interquartile range)†
39 (30–49)
36 (30–46)
40 (30–50)


0.34‡
HIV†
Positive 18 (9.6) 7 (16.3) 11 (7.6) 1.8 0.96−3.51 0.09
Negative
170 (90.4)
36 (83.7)
134 (92.4)
Referent


Health care worker
Yes 2 (1.1) 1 (2.3) 1 (0.7) 2.2 0.54–9.01 0.27
No
189 (98.9)
43 (97.7)
146 (99.3)
Referent


Homelessness
Yes 11(5.8) 4 (9.1) 7 (4.8) 1.64 0.72−3.75 0.24
No
180 (94.2)
40 (90.9)
140 (95.2)
Referent


Employment
Employed 42 (22.0) 10 (22.7) 32 (21.8) Referent
Unemployed 114 (59.7) 25 (56.8) 89 (60.5) 0.92 0.48–1.75 0.80
Not working§
35 (18.3)
9 (20.5)
26 (17.7)
1.08
0.49–2.35
0.85
History of imprisonment ¶
Yes 51(26.8) 10 (22.7) 41 (28.1) 0.8 0.43–1.50 0.49
No
139 (73.2)
34 (77.3)
105 (71.9)
Referent


Alcohol abuse
Yes 35 (18.3) 9 (20.5) 26 (17.8) 1.15 0.61–2.16 0.67
No
156 (81.7)
35 (79.5)
121 (82.3)
Referent


Illicit drugs use#
Yes 12 (6.3) 3 (7.0) 9 (6.2) 1.11 0.40–3.06 0.85
No
177 (93.7)
40 (3.05)
137 (93.8)
Referent


Diabetes¶
Yes 13 (6.8) 3 (7.0) 10(6.8) 1.02 0.36–2.86 0.97
No
177 (93.2)
40 (93.0)
137 (93.2)
Referent


Contact with TB patient
Yes 55 (28.8) 16 (36.4) 39 (26.5) 1.45 0.85–2.49 0.17
No 130 (68.1) 26 (59.1) 104 (70.7) Referent
Unknown
6 (3.1)
2 (4.5)
4 (2.8)



Cavities on radiograph¶
Yes 88 (46.3) 24 (54.5) 64 (43.8) 1.39 0.83–2.34 0.21
No
102 (53.7)
20 (45.5)
82 (56.2)
Referent


Sputum microscopy¶
Positive 140 (73.7) 39 (88.6) 101(69.2) 2.78 1.16–6.67 0.02
Negative
50 (26.3)
5 (11.4)
45 (30.82)
Referent


Site of disease¶
Any pulmonary 189 (99.5) 44 (100) 145 (99.3) 0.59
Extrapulmonary only
1 (0.5)
0
1 (0.7)
Referent


Symptoms
Yes 122 (63.9) 27 (61.4) 95 (64.6) 0.9 0.53–1.53 0.69
No
69 (36.1)
17 (38.6)
52 (35.4)
Referent


Reasons for TB screening
Symptomatic 110 (57.6) 27 (61.4) 83 (56.4) 1.1 0.62–1.79 0.85
Abnormal finding on radiograph 6 (3.1) 0 6 (4.1)
Contact with TB patient 2 (1.1) 0 2 (1.4)
Routine screening 73 (38.2) 17 (38.6) 56 (38.1) Referent

*Values are no. (%) patients except as indicated. Cases were diagnosed at the Vladimir Regional TB Dispensary, Vladimir Region, Russia. MDR TB, multidrug-resistant TB. –, not applicable.
†Age and HIV status missing for 3 patients.
‡Wilcoxon rank sum test.
§Reasons for not working: retired, student, housewife, disabled.
¶Information was missing for 1 patient.
#Drug use data were missing for 2 patients.

Main Article

Page created: October 19, 2015
Page updated: October 19, 2015
Page reviewed: October 19, 2015
The conclusions, findings, and opinions expressed by authors contributing to this journal do not necessarily reflect the official position of the U.S. Department of Health and Human Services, the Public Health Service, the Centers for Disease Control and Prevention, or the authors' affiliated institutions. Use of trade names is for identification only and does not imply endorsement by any of the groups named above.
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