Volume 21, Number 11—November 2015
Dispatch
Epidemiology of Primary Multidrug-Resistant Tuberculosis, Vladimir Region, Russia
Julia Ershova
, Grigory V. Volchenkov, Dorothy A. Kaminski, Tatiana R. Somova, Tatiana A. Kuznetsova, Natalia V. Kaunetis, J. Peter Cegielski, and Ekaterina V. Kurbatova
, Grigory V. Volchenkov, Dorothy A. Kaminski, Tatiana R. Somova, Tatiana A. Kuznetsova, Natalia V. Kaunetis, J. Peter Cegielski, and Ekaterina V. Kurbatova
Table
Association between sociodemographic and clinical characteristics of persons with newly diagnosed cases of non–MDR TB and MDR TB, Vladimir Region, Russia, 2012*
| Characteristic | Total, n = 191 | MDR TB, n = 44 | Non–MDR TB, n = 147 | Prevalence ratio | 95% CI | p value |
|---|---|---|---|---|---|---|
| Sex | ||||||
| Male | 146 (74.4) | 34 (77.3) | 112 (76.2) | 1.05 | 0.56–1.95 | 0.88 |
| Female |
45 (23.6) |
10 (22.7) |
35 (23.8) |
Referent |
||
| Median age, y (interquartile range)† |
39 (30–49) |
36 (30–46) |
40 (30–50) |
0.34‡ |
||
| HIV† | ||||||
| Positive | 18 (9.6) | 7 (16.3) | 11 (7.6) | 1.8 | 0.96−3.51 | 0.09 |
| Negative |
170 (90.4) |
36 (83.7) |
134 (92.4) |
Referent |
||
| Health care worker | ||||||
| Yes | 2 (1.1) | 1 (2.3) | 1 (0.7) | 2.2 | 0.54–9.01 | 0.27 |
| No |
189 (98.9) |
43 (97.7) |
146 (99.3) |
Referent |
||
| Homelessness | ||||||
| Yes | 11(5.8) | 4 (9.1) | 7 (4.8) | 1.64 | 0.72−3.75 | 0.24 |
| No |
180 (94.2) |
40 (90.9) |
140 (95.2) |
Referent |
||
| Employment | ||||||
| Employed | 42 (22.0) | 10 (22.7) | 32 (21.8) | Referent | ||
| Unemployed | 114 (59.7) | 25 (56.8) | 89 (60.5) | 0.92 | 0.48–1.75 | 0.80 |
| Not working§ |
35 (18.3) |
9 (20.5) |
26 (17.7) |
1.08 |
0.49–2.35 |
0.85 |
| History of imprisonment ¶ | ||||||
| Yes | 51(26.8) | 10 (22.7) | 41 (28.1) | 0.8 | 0.43–1.50 | 0.49 |
| No |
139 (73.2) |
34 (77.3) |
105 (71.9) |
Referent |
||
| Alcohol abuse | ||||||
| Yes | 35 (18.3) | 9 (20.5) | 26 (17.8) | 1.15 | 0.61–2.16 | 0.67 |
| No |
156 (81.7) |
35 (79.5) |
121 (82.3) |
Referent |
||
| Illicit drugs use# | ||||||
| Yes | 12 (6.3) | 3 (7.0) | 9 (6.2) | 1.11 | 0.40–3.06 | 0.85 |
| No |
177 (93.7) |
40 (3.05) |
137 (93.8) |
Referent |
||
| Diabetes¶ | ||||||
| Yes | 13 (6.8) | 3 (7.0) | 10(6.8) | 1.02 | 0.36–2.86 | 0.97 |
| No |
177 (93.2) |
40 (93.0) |
137 (93.2) |
Referent |
||
| Contact with TB patient | ||||||
| Yes | 55 (28.8) | 16 (36.4) | 39 (26.5) | 1.45 | 0.85–2.49 | 0.17 |
| No | 130 (68.1) | 26 (59.1) | 104 (70.7) | Referent | ||
| Unknown |
6 (3.1) |
2 (4.5) |
4 (2.8) |
– |
||
| Cavities on radiograph¶ | ||||||
| Yes | 88 (46.3) | 24 (54.5) | 64 (43.8) | 1.39 | 0.83–2.34 | 0.21 |
| No |
102 (53.7) |
20 (45.5) |
82 (56.2) |
Referent |
||
| Sputum microscopy¶ | ||||||
| Positive | 140 (73.7) | 39 (88.6) | 101(69.2) | 2.78 | 1.16–6.67 | 0.02 |
| Negative |
50 (26.3) |
5 (11.4) |
45 (30.82) |
Referent |
||
| Site of disease¶ | ||||||
| Any pulmonary | 189 (99.5) | 44 (100) | 145 (99.3) | 0.59 | ||
| Extrapulmonary only |
1 (0.5) |
0 |
1 (0.7) |
Referent |
||
| Symptoms | ||||||
| Yes | 122 (63.9) | 27 (61.4) | 95 (64.6) | 0.9 | 0.53–1.53 | 0.69 |
| No |
69 (36.1) |
17 (38.6) |
52 (35.4) |
Referent |
||
| Reasons for TB screening | ||||||
| Symptomatic | 110 (57.6) | 27 (61.4) | 83 (56.4) | 1.1 | 0.62–1.79 | 0.85 |
| Abnormal finding on radiograph | 6 (3.1) | 0 | 6 (4.1) | – | ||
| Contact with TB patient | 2 (1.1) | 0 | 2 (1.4) | – | ||
| Routine screening | 73 (38.2) | 17 (38.6) | 56 (38.1) | Referent |
*Values are no. (%) patients except as indicated. Cases were diagnosed at the Vladimir Regional TB Dispensary, Vladimir Region, Russia. MDR TB, multidrug-resistant TB. –, not applicable.
†Age and HIV status missing for 3 patients.
‡Wilcoxon rank sum test.
§Reasons for not working: retired, student, housewife, disabled.
¶Information was missing for 1 patient.
#Drug use data were missing for 2 patients.
Page created: October 19, 2015
Page updated: October 19, 2015
Page reviewed: October 19, 2015
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