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Volume 21, Number 12—December 2015
Synopsis

Opportunistic Pulmonary Bordetella hinzii Infection after Avian Exposure

Aude FabreComments to Author , Clarisse Dupin, François Bénézit, Julien Goret, Caroline Piau, Stéphane Jouneau, Sophie Guillot, Francis Mégraud, Samer Kayal, Benoit Desrues, Alain Le Coustumier, and Nicole Guiso
Author affiliations: Centre Hospitalier de Cahors, Cahors, France (A. Fabre, A. Le Coustumier); Centre Hospitalo-Universitaire de Bordeaux, Bordeaux, France (A. Fabre, J. Goret, F. Mégraud); Centre Hospitalo-Universitaire de Rennes, Rennes, France (C. Dupin, F. Benezit, C. Piau, S. Jouneau, S. Kayal, B. Desrues); Institut Pasteur, Centre National de Référence de la coqueluche et des autres bordetelloses, Paris, France (S. Guillot, N. Guiso)

Main Article

Table

Antimicrobial drug susceptibility testing for human Bordetella hinzii isolates by the Etest method*

Antimicrobial drug Case-patient 1† Case-patient 2† BC-306 (11) BC-305 (11) BL-3210 (3) Hristov et al. isolate 1 (10)‡ Hristov et al. isolate 2 (10)‡ Hristov et al. isolate 3 (10)‡
Amoxicillin ND 32 16§ 16§ 12§ ND ND ND
Amoxicillin/clavulanic acid ND ND 32 16 ND ND ND ND
Ampicillin/sulbactam ND ND 16/8 16/8 ND ND ND ND
Piperacillin 0.38 ND ND ND ND 32 ND ND
Piperacillin/tazobactam 0.25 0.75 1 1 ND ND ND ND
Ticarcillin ND ND ND ND ND >32 >64 ND
Ticarcillin/clavulanic acid ND 32 32 64 ND ND ND ND
Cefoxitine ND >256 ND ND ND ND ND ND
Cefotaxime ND >32 ND ND >32 ND ND ND
Ceftriaxone ND ND 64 64 ND ND ND >32
Ceftazidime 1.5 2 4 4 4 ND ND ND
Cefepime ND 6 8 8 ND >16 >16 >16
Ertapenem 3 0.023 ND ND ND ND ND ND
Imipenem 0.75 1.5 2 2 1 ND ND ND
Meropenem 1 0.125 ND ND ND ≤1 8 4
Doripenem 0.5 0.125 ND ND ND ND ND ND
Aztreonam ND ND ND ND ND >16 >16 ND
Gentamicin 0.75 4 2 4 4 ≤1 4 ≤2
Tobramycin 4 48 ND ND ND >8 >8 4
Amikacin 2 16 ND ND ND 16 ≤4 ≤8
Clarithromycin 4 ND ND ND ND ND ND ND
Clindamycin >256 ND ND ND ND ND ND ND
Rifampin 1 >32 N ND ND ND ND ND
Levofloxacin >32 0.25 2 2 ND ND ND ND
Ciprofloxacin >32 0.75 4 4 >32 >2 >2 >2
Moxifloxacin 4 0.5 ND ND ND ND ND ND
Cotrimoxazole 0.38 ND 0.047 0.023 ND ≤0.5/9.5 2/38 ND
Vancomycin >32 >256 ND ND ND ND ND ND
Teicoplanin >32 >256 ND ND ND ND ND ND
Daptomycine >256 >256 ND ND ND ND ND ND
Linezolid >256 >256 ND ND ND ND ND ND
Fusidic acid >32 ND ND ND ND ND ND ND
Tetracycline ND ND ND ND 0.38 ND ND ND
Minocycline 1 ND ND ND ND ≤2 >8 ND
Tigecycline 0.5 0.38 ND ND ND ND ND ND
Colistin 0.38 0.094 ND ND ND ND ND ND
Fosfomycine >1024 >1024 ND ND ND ND ND ND

*Values are MICs as determined by Etest in μg/mL ND, not determined.
†This study.
‡Isolates 1, 2, and 3 of Hristov et al. case correspond to respiratory isolates (1 and 2) and blood isolate (isolate 3).
§Ampicillin rather than amoxicillin was tested.

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References
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Page updated: November 12, 2015
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