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Volume 21, Number 12—December 2015
Letter

Tickborne Lymphadenopathy Complicated by Acute Myopericarditis, Spain

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To the Editor: Dermacentor-borne necrosis erythema lymphadenopathy/tickborne lymphadenopathy (DEBONEL/TIBOLA) is an apparently benign, self-limiting rickettsial disease transmitted by Dermacentor ticks (1,2). Rickettsia slovaca was the first etiologic agent isolated, but other species, such as R. raoultii and Candidatus R. rioja, also might be involved (36). If the scalp is affected, a larger number of agents (including Francisella tularensis, Bartonella henselae, R. massiliae, R. sibirica mongolitimonae, and Borrelia burgdorferi) should be considered within the differential diagnosis of a similar syndrome recently named scalp eschar associated with neck lymphadenopathy after a tick bite (SENLAT) (7). Nevertheless, in Spain, only R. slovaca, Candidatus R. rioja, and F. tularensis are known to cause DEBONEL/TIBOLA/SENLAT (4,6). This entity is considered an emerging rickettsiosis in Europe; cases have been reported from Italy, France, Hungary, Germany, and Portugal (8).

We recently saw a patient in whom acute myopericarditis developed after he was bitten by a large tick on the scalp and showed clinical signs of DEBONEL/TIBOLA/SENLAT, most likely attributable to R. slovaca or Candidatus R. rioja infection. The patient, a previously healthy 28-year-old man, went on a day-long hiking trip to the northern mountains of Madrid (central Spain; mean altitude 1,300 m) on November 2, 2014. Three days later, he noticed a mild ache on the occipital area of his scalp and found an attached tick that he removed with his fingers. A week later, he sought care from an infectious disease specialist because of itchy discomfort at the area of the tick bite.

Figure

Thumbnail of Dermacentor-borne necrosis erythema lymphadenopathy/tickborne lymphadenopathy/scalp eschar associated with neck lymphadenopathy after a tick bite. Shown is an erythematous, punctiform lesion in the scalp (arrow head), accompanied by enlarged occipital lymph nodes

Figure. Dermacentor-borne necrosis erythema lymphadenopathy/tickborne lymphadenopathy/scalp eschar associated with neck lymphadenopathy after a tick bite. Shown is an erythematous, punctiform lesion in the scalp (arrow), accompanied by enlarged occipital lymph nodes

Examination revealed an erythematous and elevated punctiform lesion with mild fluctuation in the occipital region accompanied by tender, small lymph node enlargement of both occipital lymphatic chains (Figure). No widespread rash was present. DEBONEL/TIBOLA/SENLAT was diagnosed, and doxycycline (100 mg every 12 hours) was initiated. IgG titer against spotted fever group Rickettsia (SFGR) was 1:128. Four days later, the patient sought care at an emergency department, reporting retrosternal chest pain. Electrocardiogram revealed a diffuse ST-segment elevation with PR-segment depression; serum creatine phosphokinase and troponin T levels were 327 IU/L (reference range 10–190 IU/L) and 420 ng/mL (reference <14 ng/mL), respectively. Myopericarditis was diagnosed. A transthoracic echocardiogram ruled out pericardial effusion, valve vegetations, and left ventricular dysfunction; cardiovascular magnetic resonance imaging performed 4 days later showed myocardial inflammation. Blood cultures were sterile, pneumococcal urinary antigen test result was negative, and IgM against coxsackievirus and Mycoplasma pneumoniae were not detected. Nonsteroidal antiinflammatory drugs were prescribed. The patient improved clinically, and electrocardiogram findings resolved. The patient received doxycycline for 4 weeks.

On a convalescent-phase serum specimen collected after 8 weeks, indirect immunofluorescence assays (IFA) for IgG against SFGR were performed in Spain’s national reference center for rickettsioses (Hospital San Pedro–Centro de Investigación Biomédica de La Rioja [CIBIR], Logroño, Spain). Commercial (Focus Diagnostics, Cypress, CA, USA) and in-house R. conorii, R. slovaca, and R. raoultii antibody testing showed an IgG titer of 1:512 against the 3 species. A subsequent cross-adsorption assay using R. slovaca, R. raoultii, and R. conorii antigens prepared on the basis of strains from the collection at Hospital San Pedro-CIBIR showed a decrease in IgG titers against R. conorii and R. raoultii to 1:64 and 1:256, respectively, whereas titer against R. slovaca remained at 512. IFA against Bartonella spp. and C. burnetii (Focus Diagnostics), chemiluminescence immunoassay for B. burgdorferi (Liason, DiaSorin, Spain), and in-house microagglutination assay for F. tularensis were not reactive. The patient recovered, with only a residual scarring alopecia on the occipital region of the scalp and without cardiac dysfunction after 9-month follow-up.

Myopericarditis is a rare complication of rickettsiosis, usually associated with R. rickettsii and R. conorii (9). Although tetracycline-induced cardiac adverse reactions have been described (10) and the patient reported here had signs of myopericarditis shortly after the initiation of doxycycline, he completed a 4-week treatment without recurrence. Therefore, the clinical picture seems unlikely to be attributable to doxycycline-induced toxicity. Because the patient was bitten in November (when only Dermacentor spp. ticks are active in central Spain), we have further epidemiologic evidence for attributing the infection to SFGR causing DEBONEL/TIBOLA/SENLAT. After serum adsorption, IFA titer against R. slovaca was 3-fold higher than that against R. conorii. R. slovaca and Candidatus R. rioja are the species most commonly found in D. marginatus ticks and in cases of DEBONEL/TIBOLA/SENLAT in Spain (8).

In view of the seroconversion to Rickettsia spp. with negative test results for other possible causative agents and the clinical response to doxycycline, rickettsiosis caused by R. slovaca or Candidatus R. rioja remains the most probable diagnosis. Because DEBONEL/TIBOLA/SENLAT is an emerging disease, physicians should consider that this entity may be associated with systemic complications similar to those of other tickborne rickettsioses.

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Acknowledgments

We thank P. Anda for providing the F. tularensis antigen.

M.F.R. holds a clinical research contract “Juan Rodés” (JR14/00036) from the Spanish Ministry of Economy and Competitiveness, Instituto de Salud Carlos III.

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José Tiago SilvaComments to Author , Francisco López-Medrano, Mario Fernández-Ruiz, Elena Resino Foz, Aránzazu Portillo, José A. Oteo, and José Maria Aguado

Author affiliations: Instituto de Investigación Hospital “12 de Octubre” (i+12), Madrid, Spain (J.T. Silva, F. López-Medrano, M. Fernández-Ruiz, E.R. Foz, J.M. Aguado); Centro de Investigación Biomédica de La Rioja, Logroño, Spain (A. Portillo, J.A. Oteo)

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References

  1. Oteo  JA, Ibarra  V. DEBONEL (Dermacentor-borne-necrosis-erythema-lymphadenopathy). A new tick-borne disease? [in Spanish]. Enferm Infecc Microbiol Clin. 2002;20:512.PubMed
  2. Lakos  A. Tick-borne lymphadenopathy (TIBOLA). Wien Klin Wochenschr. 2002;114:64854 .PubMed
  3. Cazorla  C, Enea  M, Lucht  F, Raoult  D. First isolation of Rickettsia slovaca from a patient, France. Emerg Infect Dis. 2003;9:135. DOIPubMed
  4. Oteo  JA, Ibarra  V, Blanco  JR, Martínez de Artola  V, Márquez  FJ, Portillo  A, Dermacentor-borne necrosis erythema and lymphadenopathy: clinical and epidemiological features of a new tick-borne disease. Clin Microbiol Infect. 2004;10:32731. DOIPubMed
  5. Portillo  A, Ibarra  V, Santibáñez  S, Pérez-Martínez  L, Blanco  JR, Oteo  JA. Genetic characterisation of ompA, ompB and gltA genes from Candidatus Rickettsia rioja. Clin Microbiol Infect. 2009;15(Suppl 2):3078. DOIPubMed
  6. Pérez-Pérez  L, Portillo  A, Allegue  F, Zulaica  A, Oteo  JA, Caeiro  JL, Dermacentor-borne necrosis erythema and lymphadenopathy (DEBONEL): a case associated with Rickettsia rioja. Acta Derm Venereol. 2010;90:2145. DOIPubMed
  7. Dubourg  G, Socolovschi  C, Del Giudice  P, Fournier  PE, Raoult  D. Scalp eschar and neck lymphadenopathy after tick bite: an emerging syndrome with multiple causes. Eur J Clin Microbiol Infect Dis. 2014;33:144956. DOIPubMed
  8. Oteo  JA, Portillo  A. Tick-borne rickettsioses in Europe. Ticks Tick Borne Dis. 2012;3:271–8.
  9. Shah  SS, McGowan  JP. Rickettsial, ehrlichial and Bartonella infections of the myocardium and pericardium. Front Biosci. 2003;8:e197201. DOIPubMed
  10. Lebrun-Vignes  B, Kreft-Jais  C, Castot  A, Chosidow  O. Comparative analysis of adverse drug reactions to tetracyclines: results of a French national survey and review of the literature. Br J Dermatol. 2012;166:133341 . DOIPubMed

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Cite This Article

DOI: 10.3201/eid2112.150672

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Table of Contents – Volume 21, Number 12—December 2015

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José Tiago Silva, Unidad de Enfermedades Infecciosas, Hospital Universitario “12 de Octubre,” Centro de Actividades Ambulatorias, Planta 2ª, Bloque D. Avda de Córdoba, s/n. Postal Code 28041, Madrid, Spain

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Page created: November 17, 2015
Page updated: November 17, 2015
Page reviewed: November 17, 2015
The conclusions, findings, and opinions expressed by authors contributing to this journal do not necessarily reflect the official position of the U.S. Department of Health and Human Services, the Public Health Service, the Centers for Disease Control and Prevention, or the authors' affiliated institutions. Use of trade names is for identification only and does not imply endorsement by any of the groups named above.
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